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  • 1
    Digitale Medien
    Digitale Medien
    Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice (2003)
    [s.l.] : Nature Publishing Group
    Nature medicine 9 (2003), S. 1477-1483 
    Details
    ISSN: 1546-170X
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] We recently reported that mice deficient in the programmed cell death-1 (PD-1) immunoinhibitory coreceptor develop autoimmune dilated cardiomyopathy (DCM), with production of high-titer autoantibodies against a heart-specific, 30-kDa protein. In this study, we purified the 30-kDa protein from heart ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/nm955
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  • 2
    Digitale Medien
    Digitale Medien
    5′-AMP is a direct precursor of cytokinin in Dictyostelium discoideum (1978)
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 545-547 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Fig. 1 Thin-layer chromatography of the products synthesised in vitro using 14C-isopentenylpyrophosphate in the absence (a) or presence (b) of the supernatant of nondialysed, boiled S-100. The reaction mixture contained 20 mM Tris-HCl (pH 7.5), 5 mM magnesium acetate, 0.05 jiCi of ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/271545a0
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  • 3
    Digitale Medien
    Digitale Medien
    Natural and synthetic non-peptide antigens recognized by human γδ T cells (1995)
    [s.l.] : Nature Publishing Group
    Nature 375 (1995), S. 155-158 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] To characterize the backbone structure of the natural mycobacterial antigens recognized by human V72V〈52-bearing T cells, mycobacterial preparations were carefully examined by adsorption and anion-exchange column chromatography. As previously described, activated charcoal failed ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/375155a0
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  • 4
    Digitale Medien
    Digitale Medien
    Bax and Bcl-2 expressions predict response to radiotherapy in human cervical cancer (1998)
    Springer
    Journal of cancer research and clinical oncology 124 (1998), S. 503-510 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Key words Bax ; Bcl-2 ; Radiotherapy ; Cervical carcinoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: AbstractPurpose: The ratio of Bcl-2 to Bax expression determines survival or death following an apoptotic stimulus. In order to establish a new predictor of the outcome of treatment for human cervical carcinoma, we investigated the relationship between the expressions of the Bax and Bcl-2 proteins and the response to radiotherapy after the administration of 10.8 Gy. Methods: A total of 44 patients with histologically proven carcinoma of the uterine cervix, including three with recurrent cervical stump carcinomas, were treated with definitive radiotherapy. The presence of mutations in exons 5–8 of the p53 gene was analyzed by a single-strand conformation polymorphism analysis and DNA sequencing. Results: Forty patients were found to have wild-type p53, and the remaining four had mutant p53. The Bax and Bcl-2 protein expressions prior to radiotherapy did not correlate with response and survival. However, the Bax and Bcl-2 protein expressions after radiotherapy correlated with both response and survival. Bax-positive tumors showed significantly better responses than the Bax-negative tumors after 10.8 Gy radiation (P = 0.0002). In contrast, the Bcl-2-positive tumors showed significantly poorer responses than the Bcl-2-negative tumors after radiation (P = 0.002). Increased Bax expression after the 10.8 Gy radiotherapy was found to be correlated with good survival (P = 0.04). In contrast, increased Bcl-2 expression after such radiotherapy was correlated with poor survival (P = 0.002). Conclusion: The levels of Bax and Bcl-2 expression after 10.8 Gy radiotherapy are useful prognostic markers in patients with human cervical carcinoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004320050206
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  • 5
    Digitale Medien
    Digitale Medien
    Histopathological changes in rabbit uterus carcinoma after transcatheter arterial embolization using cisplatin (1996)
    Springer
    Cancer chemotherapy and pharmacology 38 (1996), S. 317-322 
    Details
    ISSN: 1432-0843
    Schlagwort(e): Key words Rabbit ; VX2 uterine cancer ; Embolization ; Cisplatin ; Apoptosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effects of chemoembolization with cisplatin on gynecological malignancy were investigated using rabbit uterine tumors. A group of 20 rabbits were subjected to inoculation of the uterus with 5×107 VX2 carcinoma cells and 4 weeks later were divided into four groups, each consisting of five rabbits: an untreated control group, a group given cisplatin intraarterially (IA), a group subjected to transcatheter arterial embolization (TAE) with Gelfoam particles and a group subjected to transcatheter chemoembolization (TACE) with Gelfoam particles plus 1 mg/kg cisplatin. All groups were examined histologically 2 days after treatment. The untreated control group was further investigated 4 weeks after inoculation. In the untreated control group, the tumor cell nuclei varied in size and were irregular in form, and multiple nuclei and nuclear division were also observed. No necrotic zones were found up to 4 weeks after inoculation. The IA group showed no necrosis, but a few apoptotic cells were scattered throughout the tumor. In the TAE group, necrosis was observed in the center of the tumors, but proliferating cells persisted at the periphery. In the TACE group, necrosis was observed in the central part with many apoptotic cells surrounding the necrotic region in layers. The proliferating cell nuclear antigen (PCNA) index was 95.88% in the untreated control group, 86.6% in the IA group, and 8.62% in the TACE group, indicating a significant reduction in cell proliferation in the TACE group. These findings suggest that TACE results in more effective cytotoxicity than the other two treatments in uterine cancer tumor transplants.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002800050489
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  • 6
    Digitale Medien
    Digitale Medien
    Effects of multimodal treatment and hyperthermia on hepatic tumors (1992)
    Springer
    Cancer chemotherapy and pharmacology 31 (1992), S. S111 
    Details
    ISSN: 1432-0843
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The therapeutic results of Lp-TAE (transcatheter arterial embolization in the presence or absence of Gelfoam particles preceded by the infusion of a mixture of lipiodol and an anticancer drug via the proper hepatic artery) or DSM-TAE (transcatheter arterial embolization with degradable starch microspheres and the arterial injection of anticancer drugs via the hepatic artery) combined with hyperthermia were evaluated in 30 patients with hepatocellular carcinoma (HCC), 5 subjects with hepatic cholangiocarcinoma, and 22 patients with metastatic liver carcinoma. Hyperthermia was performed using an 8-MHz Thermotron RF-8. Tumor temperatures could be measured in 31 patients (54.4%) with malignant lesions of the liver who had undergone hyperthermia. The mean maximal temperature (Tmax) was 41.5°C in the metastatic liver cancers. The efficiency of heating in HCC was unfavorable, i.e., the mean Tmax was only 40.7 °C. The rise in tumor temperature was greater in either HCC or metastatic liver carcinoma associated with portal invasion of the lesion. The tumor-temperature elevation was also excellent in HCC that had been subjected to embolization with DSM in combination with hyperthermia. The response rate (complete response plus partial response) was as high as 40% (4/10) in the group in which the tumor temperature could be raised to 42°C or more. Among the 52 patients who had shown a high pretreatment level of tumor marker, that value decreased in 34 cases (65.4%), and the decrease was greater than 50% in 22 cases (42.3%).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687119
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  • 7
    Digitale Medien
    Digitale Medien
    Successful Transcatheter Embolotherapy with a New Platinum Microcoil: The Berenstein Liquid Coil (1998)
    Springer
    CardioVascular & interventional radiology 21 (1998), S. 297-299 
    Details
    ISSN: 1432-086X
    Schlagwort(e): Key words: Embolization—Platinum coils—Arteries, embolism—Pulmonary arteries—Spleen, interventional procedure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Purpose: To determine the usefulness of a new platinum microcoil, the Berenstein Liquid Coil for vascular embolization. Methods: Nine patients underwent transcatheter arterial embolization with liquid coils. The occluded vessels included the splenic artery in four patients, gastroduodenal artery in two, arteriovenous malformation or fistula in two, and middle hepatic artery in one. All coils were delivered with a saline flush through a Tracker-18 catheter. Results: All arteries except one were successfully occluded in a one-stage procedure using liquid coils. No friction was observed between the liquid coils and the microcatheter regardless of the tortuosity of the artery. Platelet counts in all patients had increased after splenic embolization. In two patients with liver tumors, perfusion to the inappropriate area during intraarterial chemotherapy was prevented by selective embolization. Life-threatening bleeding was successfully treated by gastroduodenal artery occlusion. No complications were encountered. Conclusion: The Berenstein Liquid Coil provides easy, safe, and rapid vascular occlusion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002709900264
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  • 8
    Digitale Medien
    Digitale Medien
    Codon usage, genetic code and phylogeny of Dictyostelium discoideum mitochondrial DNA as deduced from a 7.3-kb region (1995)
    Springer
    Current genetics 27 (1995), S. 249-256 
    Details
    ISSN: 1432-0983
    Schlagwort(e): Dictyostelium discoideum Mitochondria DNA ; Genetic code Codon capture theory ; Molecular phylogeny
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract We have sequenced a region (7 376-bp) of the mitochondrial (mt) DNA (54 kb) of the cellular slime mold, Dictyostelium discoideum. From the DNA and amino-acid sequence comparisons with known sequences, genes for ATPase subunit 9 (ATP), cytochrome b (CYTB), NADH dehydrogenase subunits 1, 3 and 6 (ND1, ND3 and ND6), small subunit rRNA (SSU rRNA) and seven tRNAs (Arg, Asn, Cys, Lys, f-Met, Met and Pro) have been identified. The sequenced region of the mtDNA has a high average A+T-content (70.8%). The A+T-content of protein-genes (73.6%) is considerably higher than that of RNA genes (61.3%). Even with the strong AT-bias, the genetic code employed is most probably the universal one. All seven tRNAs are able to form typical clover leaf structures. The molecular phylogenetic trees of CYTB and SSU rRNA suggest that D. discoideum is closer to green plants than to animals and fungi.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00326157
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  • 9
    Digitale Medien
    Digitale Medien
    An NADP-linked acetoacetyl CoA reductase from Zoogloea ramigera (1977)
    Springer
    Archives of microbiology 114 (1977), S. 211-217 
    Details
    ISSN: 1432-072X
    Schlagwort(e): Poly-β-hydroxybutyrate ; PHB ; Acetoacetyl CoA reductase ; Zoogloea ramigera
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Zoogloea ramigera I-16-M was found to contain two stereospecific acetoacetyl CoA reductases; one was NADP+-linked and d(-)-β-hydroxybutyryl CoA specific and the other was NAD+-linked and l(+)-isomer specific. The NADP+-linked enzyme, purified approximately 150-fold, had a pH optimum for the reduction of acetoacetyl CoA at 8.1, but no definite pH optimum for the oxidation of β-hydroxybutyryl CoA. The apparent Michaelis constants for acetoacetyl CoA and NADPH were 8.3 and 21 μM, respectively. The enzyme was markedly inhibited by acetoacetyl CoA at concentrations higher than 10 μM. The incorporation of [1-14C]acetyl CoA into poly-β-hydroxybutyrate (PHB) by bacterial crude extract (containing β-ketothiolase, acetoacetyl CoA reductases, enoyl CoA hydratases and PHB synthases) or by a system reconstituted from purified preparations of β-ketothiolase, acetoacetyl CoA reductase and PHB synthase, was observed only in the presence of NADPH, but not NADH. Among various enzymes involved in PHB metabolism, only the specific activity of glucose 6-phosphate dehydrogenase was elevated 5-fold within 2 h after the addition of glucose to the cells grown in the basal medium. These findings suggest that, in Z. ramigera I-16-M, acetoacetyl CoA is directly reduced to d(-)-β-hydroxybutyryl CoA by the NADP+-dependent reductase, and PHB synthesis is at least partially controled by NADPH availability through glucose 6-phosphate dehydrogenase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00446864
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  • 10
    Digitale Medien
    Digitale Medien
    ORF209 of Dictyostelium discoideum mitochondrial DNA has a homologue in chloroplast DNA (1990)
    Springer
    Plant molecular biology 15 (1990), S. 659-660 
    Details
    ISSN: 1573-5028
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00017840
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