ISSN:
1573-8221
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The authors studied the effect of D,L-cycloserine, the dihydrochloride of the ethyl ether of β-amino-oxyalanine (preparation KKh-9), semihydrochloride of β-aminooxyalanine (preparation KKh-14) and of cyclotheronine (preparation KKh-11) on the amino group shift from glutaminic acid to pyruvic acid in rat liver homogenates. D,L-cycloserine and preparation KKh-9 in 10−5M to 10−4M concentration, tend to depress this process by 50–100 %. Preparation KKh-14 depresses the process by 45% in 10−4M concentration and by 70% in 10−3M concentration. 10−3M concentration of preparation KKh-11 depresses the process by 25% only. An admixture of pyridoxal or phosphopyridoxal, in concentration 5 times above that of D,L-cycloserine, did not restore the process depressed by the latter. It is conjectured that as a result of the combination of phosphopyridoxal-proteid with cycloserine a stable complex compound is formed; for the stabilization of the above complex the cyclic structure and the nonsubstituted hydrogen of the cycloserine molecule in the 5th position is important.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00783789
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