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  • 1
    Electronic Resource
    Electronic Resource
    Are ACA and Scl 70 antibodies mutually exclusive? (1990)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 122 (1990), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Serological studies using indirect immunofluorescence, double immunodiffusion and immunoblot with recombinant Topo I and kinetochore antigens were performed in 180 patients with systemic scleroderma. In the sera of 10 patients, we found coexisting ACA and Scl 70 antibodies, and this was confirmed by all three methods. The relationship between the coexistence of these antibodies and the clinical features of the disease is not clear, although in all these cases there was pronounced vascular involvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1990.tb08266.x
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  • 2
    Electronic Resource
    Electronic Resource
    Autoantibodies to nucleolar antigens in systemic scleroderma: clinical correlations (1990)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 123 (1990), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Indirect immunofluorescence (IIF) and double immunodiffusion (DID) were performed on the sera of 64 patients who had a nucleolar immunofluorescence pattern on HEp-2 cells. Forty-nine of the sera were from 296 patients with systemic scleroderma (SSc) and 15 sera were from 214 patients with systemic lupus erythematosus (SLE). A homogeneous nucleolar staining pattern was found in 45 of the 64 sera (70.3%), a clumpy fluorescence associated with fibrillarin antibody in 14 (21.8%) and a speckled pattern was found in five of the sera (7.8%).There was a clear correlation between the sera which showed a homogeneous nucleolar staining pattern with symptoms of the polymyositis/scleroderma overlap syndrome that differed from SSc with concomitant myositis. The clumpy pattern was mainly associated with diffuse scleroderma and the speckled pattern with limited scleroderma (previously called acrosclerosis).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1990.tb01445.x
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  • 3
    Electronic Resource
    Electronic Resource
    Scl 70 antibody—a specific marker of systemic sclerosis (1986)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 115 (1986), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Scl 70 antibodies were tested for in 107 patients with systemic sclerosis: 68 with acrosclerosis and 39 with diffuse scleroderma. Anticentromere antibodies (ACA) and other antinuclear antibodies (ANA) were tested for by indirect immunofiuorescence on HEp-2 cells. Positive results for Scl 70 antibodies were obtained in 77percnt; of cases of diffuse scleroderma and 44percnt; of acrosclerosis. ACA and Scl 70 antibodies were found to be mutually exclusive. If acrosclerosis cases positive for anticentromere antibodies are excluded, the percentage of acrosclerosis cases positive for Scl 70 was 63percnt;. ACA were found to be a marker of a benign, abortive subset of acrosclerosis with almost no cutaneous involvement (CREST), whereas Scl 70 did not discriminate between acrosclerosis and diffuse scleroderma. On HEp-2 cells Scl 70 positive sera gave a characteristic, fine speckled, almost homogeneous nuclear staining pattern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1986.tb06233.x
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  • 4
    Electronic Resource
    Electronic Resource
    MORPHEA WITH HIGH TITER OF FIBRONECTIN ANTIBODIES (1992)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 31 (1992), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 20-year-old man with a 9-year history of unusual subcutaneous morphea with nodular lesions in a circular arrangement and wooden-hard symmetrical induration of the arms, had high liters of fibronectin antibodies. A possible role of fibronectin and antifibronectin antibodies in the pathogenesis of scleroderma is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1992.tb03933.x
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  • 5
    Electronic Resource
    Electronic Resource
    Immunopathologic Findings in Systemic Sclerosis Patients (1989)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 28 (1989), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Direct immunofluorescence (DIF) of the skin biopsy specimens was performed in 62 patients with systemic scleroderma: 26 cases of acrosclerosis (group 1), 26 cases of diffuse scleroderma (group 2) and ten cases of transitional form acrosclerosis-diffuse scleroderma (group 3). If epidermal nuclear fluorescence and lupus band test (LBT) were considered, the results were positive in 15.3% in group 1, 42.3% in group 2, and 10% in group 3. LBT was positive in 13.5% of the cases in groups 1 and 2 and negative in group 3. The immunoglobulin deposits at the dermoepidermal consisted mainly of IgM or a combination of IgG and IgM. There was no correlation between the LBT and antinuclear antibodies as detected by indirect immunofluorescence (IIF) or double immunodiffusion (DID).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1989.tb02435.x
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  • 6
    Electronic Resource
    Electronic Resource
    Role of Cell-Mediated Immunity in Spontaneous Regression of Plane Warts (1988)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 27 (1988), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : Human papillomavirus-induced plane warts most often occur in the second decade of age. Afterward, they either spontaneously regress or are eradicated in the course of various treatments. As proved by in vivo and in vitro tests as well as clinical observations, they most often affect and persist longer in immunocompromised hosts. In this work it was confirmed that specific—ie, anti-HPV-directed, cell-mediated immunologic response plays a role in spontaneous regression of plane warts and that preservation of nonspecific immunity is prerequisite for spontaneous regression of plane warts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1988.tb02362.x
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  • 7
    Electronic Resource
    Electronic Resource
    Autoimmunity in psoriasis (1978)
    Springer
    Archives of dermatological research 261 (1978), S. 135-146 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Immunofluorescenz(IF)-Untersuchungen mittels der Methode, die die Feststellung von Stratum corneum Antikörper im Serum und ihre in vivo-Fixierung ermöglicht, wurden bei 193 Psoriasis-Fällen und 89 Kontrollpersonen durchgeführt. Es wurde nachgewiesen, daß: 1. Im allgemeinen alle völlig entwickelten, aktiven Psoriasisläsionen IgG-Ablagerungen im Stratum corneum an den Antigenseiten, angeblich in Folge ihrer in vivo-Fixierung, enthalten. 2. In verschiedenen Psoriasisabarten waren die Antigenseiten des Stratum corneum völlig oder fast völlig von in vivo-fixierten IgG-Ablagerungen gesättigt, was man im Vergleich mit der Intensität der in vitro-Reaktion mit SC-Antikörpern aufzeigen konnte. 3. In der Mehrheit, aber nicht in allen Hautveränderungen waren die Komponente 3 und 5 des Komplements in vivo-fixiert und hatten ein gleiches IF Pattern wie IgG, besonders wenn man mehrere Biopsien in einzelnen Fällen durchführte. Eine teilweise oder komplette Sättigung konnte im Vergleich mit der Intensität der in vitro-Komplement-Reaktion festgestellt werden. 4. In allen Hautveränderungen mit typischem histologischem Bild von Psoriasis waren die IF-Befunde charakteristisch. Jedoch in manchen sehr frühen Psoriasisläsionen mit noch nicht gänzlich charakteristischem histologischem Bild wurden weder IgG noch Komplement festgestellt (in 2 von 17 Fällen).In zurücktretenden Läsionen waren schwache IgG-Ablagerungen nur in einzelnen Biopsien vorhanden und das Komplement war in der Regel nicht feststellbar. 5. In der Kontrollgruppe von 89 Fällen hatten nur einzelne Biopsien das psoriasis-ähnliche IF-Pattern, jedoch in ungefähr 30% der Biopsien wurden manche Ablagerungen im Stratum corneum festgestellt, obwohl sie ein unterschiedliches IF-Muster hatten.
    Notes: Summary Immunofluorescence (IF) studies using the test providing information on the reactivity of stratum corneum (SC) antibodies and their in vivo binding have been performed in 193 cases of psoriasis and 89 cases with other dermatoses. It has been shown that: 1. Essentially all fully developed, active psoriatic lesions had IgG deposits in the stratum corneum at the sites of the SC antigen, presumably due to in vivo binding of SC antibodies. 2. In various forms of psoriasis SC antigen sites appeared to be completely or almost completely satured with in vivo deposits of IgG as seen in tests with SC antibodies. 3. In most but not all lesions complement components C3 and/or C4 was found in a comparable pattern in the SC, especially when multiple specimens of single cases were studied. Partial or complete saturation of the SC antigen could be observed by the performance of complement indirect IF tests for SC antibodies in such specimens. 4. In lesions with typical histology of psoriasis the above-mentioned immunologic characteristics appeared to be a constant finding. However, in specimens of recent lesions which had not yet developed typical histology a proportion (2 of 17) were negative both for IgG and complement deposits. In receding lesions weak deposits of IgG were present only in a few specimens and complement deposits were as a rule negative. 5. cIn a group of 89 control specimens of other dermatoses only occasional cases gave the psoriasiform IF pattern, but about 30% of the specimens gave positive reactions in the SC though these were usually of a different pattern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00447158
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  • 8
    Electronic Resource
    Electronic Resource
    Electron microscopic studies in dermatitis herpetiformis in relation to the pattern of immune deposits in the skin (1977)
    Springer
    Archives of dermatological research 259 (1977), S. 213-224 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Elektronenmikroskopische Untersuchungen wurden in 12 Fällen von Dermatitis herpetiformis durchgeführt. In 6 Fällen waren IgA-Ablagerungen in der dermo-epidermalen Zone linear und in 6 Fällen granulär, in den dermalen Papillen lokalisiert. Zum Vergleich wurden auch 6 Fälle von bullösem Pemphigoid mit typischen IgG linearen Ablagerungen in der dermoepidermalen Zone untersucht. Bei Dermatitis herpetiformis mit linearer IgA-Immunofluorescenz waren die charakteristischen Merkmale sowohl von Dermatitis herpetiformis, als auch von bullösem Pemphigoid vorhanden, sogar wenn das histologische und klinische Bild und die Ansprechbarkeit auf Sulfapyridin oder Sulfone charakteristisch für Dermatitis herpetiformis waren. Das ultrastrukturelle Muster war grundsätzlich dasselbe in Fällen von typischer Dermatitis herpetiformis mit linearen IgA-Ablagerungen und in Fällen von gemischter Form Dermatitis herpetiformis — bullöses Pemphigoid, obwohl in den letzten die Merkmale von bullösem Pemphigoid mehr ausgeprägt waren.
    Notes: Summary Electron microscopic studies were made in 12 cases of dermatitis herpetiformis: 6 of them with a continuous immunofluorescence line of IgA deposits at the dermo-epidermal junction, and the other 6 with granular IgA deposits in the dermal papillae. Six cases of bullous pemphigoid with a continuous immunofluorescence line of IgG deposits at the dermo-epidermal junction were examined similarly for comparison. In dermatitis herpetiformis with the continuous IgA line the ultrastructural characteristics both of dermatitis herpetiformis and bullous pemphigoid were present, even when the histological and clinical features as well as response to sulphapyridine and sulphones were typical of dermatitis herpetiformis. The ultrastructural pattern was essentially the same as in the cases with clinical and histological characteristics of the mixed dermatitis herpetiformis-bullous pemphigoid form, although in the latter there was some predominance of the characteristics of bullous pemphigoid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561449
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  • 9
    Electronic Resource
    Electronic Resource
    Immunoelectron microscopic studies in IgA linear dermatosis (1979)
    Springer
    Archives of dermatological research 265 (1979), S. 289-298 
    Details
    ISSN: 1432-069X
    Keywords: IgA linear immune deposits ; Dermatitis herpetiformis ; Immune deposits, lamina lucida type ; Immune deposits, dermal type ; IgA-lineare Ablagerungen ; Dermatitis herpetiformis ; immunologische Ablagerungen vom Lamina lucida-Typ ; immunologische Ablagerungen vom dermalen Typ
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In drei Fällen von IgA linear-Dermatosis wurden immunelektronenmikroskopische Untersuchungen durchgeführt. In zwei Fällen waren auch zusätzliche IgG-Ablagerungen in der Basalmembranzone vorhanden. Festgestellt wurde ein unterschiedlicher Charakter der IgA-Ablagerungen; in zwei Fällen waren sie gleichzeitig von dermalem und Lamina lucida-Typ, in einem von ihnen näher den Membranen der Basalzellen lokalisiert, so daß über der Lamina basalis ein elektronendurchsichtiger Raum entstand. Im dritten Fall waren die Ablagerungen (untersucht wurde nur IgG und Complement) ausschließlich von dermalem Typ. Es ist bemerkenswert, daß in einem früheren Fall, der durch Ablagerungen ausschließlich zunächst in der Lamina lucida charakterisiert war, nach 11/2 Jahren eine Ablagerung sowohl in der Lamina lucida als auch in der Lamina basalis sich einstellte, ohne daß das klinische Bild sich geändert hatte. Es ist möglich, daß die Lokalisation der IgA-Ablagerungen in der Basalmembranzone variabel und abhängig von der Evolution der Hautveränderungen ist.
    Notes: Summary The authors investigated three cases of IgA linear dermatosis by immunoelectron microscopy. In two of the cases there were additionally some IgG deposits in the basement membrane zone. The arrangement of the IgA deposits was found to vary. In two cases it was of the dermal and the lamina lucida type at the same time, and in one case it was so close to basal cell membranes as to leave an electronlucent space on the side facing the basal lamina. In the third case, the arrangement (only IgG and complement were studied) was exclusively of the dermal type. In one of the cases the deposits had first, i.e., 11/2 years earlier, been confined to the lamina lucida, whereas now they were also seen below the basal lamina, although the clinical condition of the patient had remained unchanged. It would seem that the localization of IgA deposits in the basement membrane zone may vary, depending on the evolution of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412386
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  • 10
    Electronic Resource
    Electronic Resource
    Autoimmunity in psoriasis (1978)
    Springer
    Archives of dermatological research 261 (1978), S. 123-134 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Antikörper gegen Stratum corneum (SC) befinden sich in Seren aller Menschen und können mittels der indirekten Immunofluorescenzmethode festgestellt werden. In Psoriasis-Herden scheinen sie in vivo im Stratum corneum fixiert zu sein. Sie fixieren Komplement in vitro, was man durch Komplement-Fixierungs-Tests unter Benutzung von anti C4 oder anti C3 Konjugaten beweisen kann. IF-Teste mit unterschiedlichen Kontrollen haben aufgezeigt, daß Stratum corneum als Antigen in Psoriasis-Läsionen nicht nur von IgG, sondern in der Mehrheit der Veränderungen auch von Komplement umgeben ist. In völlig entwickelten Läsionen wurde das Komplement in 88% der Biopsien festgestellt, weniger häufig — in ungefähr 50% — in sehr frühen linearen Hautveränderungen vom Typ des zufälligen Köbnerschen Phänomens. Diese und frühere Beobachtungen erbrigen einen indirekten Beweis, daß Antikörper SC an der Entstehung der Psoriasisherde teilnehmen, und die Komplementfixierung hier von Bedeutung sein könnte.
    Notes: Summary The stratum corneum (SC) antibodies are present in all human sera as seen by indirect immunofluorescent (IF) staining. They appear to bind in vivo to the stratum corneum of psoriatic lesions. They fix complement in vitro in a two step complement IF test system using either anti C4 or anti C3 conjugates as indicators. IF tests with proper controls showed that the SC antigen in psoriatic scales is coated not only with IgG but in a majority of the lesions also with complement. In the present studies in fully developed lesions complement was detectable in 88% of the specimens studied and in about 50% of very fresh linear lesions of unintentional Köbner type. These as well as some previously published observations afford indirect evidence for the participation of SC antibodies and the ensuing fixation of complement in the development of psoriatic lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00447157
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