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  • 1
    Electronic Resource
    Electronic Resource
    Specific effects of unilateral lesions in the flocculus upon eye movements in albino rabbits (1982)
    Springer
    Experimental brain research 45 (1982), S. 233-242 
    Details
    ISSN: 1432-1106
    Keywords: Gerebellum ; Flocculus ; Eye movement ; Kainic acid ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The horizontal vestibulo-ocular reflex (HVOR) and optokinetic response (OKR) were examined in alert albino rabbits following unilateral flocculectomy. Chemical flocculectomy with local application of kainic acid was used to avoid the retrograde degeneration of inferior olive neurons that accompanies surgical flocculectomy. Effects of chemical flocculectomy, however, were identical to those of surgical flocculectomy. The following functional deficiencies were observed in the movements of the ipsilateral eye: (1) reduction of the HVOR gain; (2) increased lag of the HVOR phase; (3) increased non-linearity of the relationship between the HVOR gain and the amplitude of turntable rotation; (4) decreased OKR gain; (5) delay with increased variation in the OKR phase; (6) impairment of rapid visual-vestibular interaction; (7) loss of the adaptation of the HVOR. Only a transient depression of the HVOR gain was seen in the contralateral eye. Control experiments with lesions in the paraflocculus, nodulus, and uvula, or lobules VI and VII, revealed no such deficiencies, except that lesions in the nodulus and uvula produced marked advancement of the HVOR phase. The effects of flocculectomy are consistent with present knowledge of both neuronal circuitry and activity of the rabbit flocculus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235783
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Adaptive modification of the rabbit's horizontal vestibulo-ocular reflex during sustained vestibular and optokinetic stimulation (1979)
    Springer
    Experimental brain research 37 (1979), S. 17-30 
    Details
    ISSN: 1432-1106
    Keywords: Adaptation ; Vestibular ; Ocular ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adaptability of the horizontal vestibulo-ocular reflex (HVOR) and the optokinetic response (OKR) was examined in alert albino rabbits during sustained runs lasting 5–12 h under four different stimulus conditions. (1) Sinusoidal rotation of the rabbit in darkness by 5 ° at 1/10 Hz, or (2) sinusoidal movement of a vertical slit light by 2.5 ° or 5 ° at 1/10 Hz around the optical axis of the stationary rabbit, affected the gain of neither the HVOR nor the OKR. (3) Combination of the stimulus as in (1) with the stationary slit light increased the gain of the HVOR gradually. A plateau at about 140% of the initial control was reached in 5 h. (4) Combination of the stimulus as in (1) with the slit light movement by 10 ° in phase with the turntable decreased the HVOR gain gradually, a plateau being obtained at about 70 % of the initial control in 5 h. Changes of the HVOR gain induced in conditions (3) and (4) were not frequency-specific and accompanied by no significant modification of either the gain or phase of the OKR or the linear property of HVOR-OKR interaction. A small but significant change of the HVOR phase was also detected under the condition (3) but not (4).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01474250
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Interaction between the horizontal vestibulo-ocular reflex and optokinetic response in rabbits (1979)
    Springer
    Experimental brain research 37 (1979), S. 1-15 
    Details
    ISSN: 1432-1106
    Keywords: Vestibular ; Ocular ; Optokinetic ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dynamic characteristics of the horizontal vestibulo-ocular reflex (HVOR), the optokinetic response (OKR), and their interactions were investigated in alert albino rabbits. For stimulation of the horizontal semicircular canals, the whole rabbit was rotated sinusoidally on a motor-driven turntable at peak-to-peak amplitudes of 5 ° to 30 ° over a frequency range of 1/30 to 1/2 Hz. Optokinetic stimulation was provided by a narrow vertical slit light source presented in front of the eye to be tested. The evoked horizontal eye movements were observed and measured by means of a closed circuit television system adapted to provide an analog signal proportional to the eye movement. The net HVOR was obtained by rotation of the turntable in darkness and the net OKR by rotation of the light source. Combining rotation of the turntable with a stationary light source immediately increased the gain and reduced the phase shift of the HVOR. The light source moving in phase with the turntable, but at twice the angular amplitude, reduced the gain and advanced the phase of the HVOR. Eye movement curves of the HVOR modified by a fixed or moving slit light could be reconstructed approximately by a linear combination of the net HVOR and OKR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01474249
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Specific Effects of Nimodipine on the Auditory System (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 522 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb33419.x
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  • 5
    Electronic Resource
    Electronic Resource
    Alleviation of mortality induced by salicylate and stress (1994)
    Springer
    Cellular and molecular life sciences 50 (1994), S. 469-474 
    Details
    ISSN: 1420-9071
    Keywords: Salicylate ; noise ; mortality ; weight ; tinnitus ; rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Protection from the deleterious effects of the interaction of environmental stress and salicylate by calcium supplement was investigated in 96 pigmented rats. Within a 2×2×4 factorial design, rats were assigned to groups defined by:A) ad lib access to 1) plain tap water, or 2) 50 mM calcium chloride solution;B) exposure to stressors consisting of daily 10 h periods of 1) 98 dB SPL noise, or 2) confinement precluding movements;C) daily injections of 233, 350, or 410 mg/kg of sodium salicylate or the saline vehicle. For subjects maintained on tap water, weight loss and mortality increased with salicylate levels, with all subjects dying in the group drinking water and injected with 410 mg/kg. Calcium protected all of the subjects in the noise stress group but not in the confined group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01920749
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Interaction of salicylate and noise results in mortality of rats (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 731-734 
    Details
    ISSN: 1420-9071
    Keywords: Salicylate ; noise ; mortality ; weight ; tinnitus ; rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Survival as a function of salicylate dose and the intensity of environmental noise was investigated in 150 adult female pigmented rats. Rats were assigned to groups (n=6/group) defined by combinations of salicylate levels from 0- (saline) to 300 mg/kg, injected subcutaneously, and noise levels from ambient noise to 98 dB SPL, presented daily for 10-h periods for up to 17 days. Mortality occurred in groups exposed to the higher combinations of salicylate and noise.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974571
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    Paper (German National Licenses)
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