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  • 1
    Electronic Resource
    Electronic Resource
    Chinese recorded classical nova two millennia ago (2007)
    [s.l.] : Nature Publishing Group
    Nature 448 (2007), S. 251-251 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir I agree with Michael M. Shara and colleagues (Nature 446, 159–162; 2007) that the star Z Camelopardalis was a classical nova a few thousand years ago. In fact, a record of the eruption exists in Chinese ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/448251d
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cardiopulmonary hemodynamics and pharmacokinetics after hepatic intraarterial infusion of 5-fluorouracil (5-FU) (1988)
    Springer
    Cancer chemotherapy and pharmacology 22 (1988), S. 251-255 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Reported 5-FU-induced cardiac side effects may be explained by drug-induced hemodynamic changes and/or by direct myocardial toxicity due to regional drug uptake. This question was studied in 11 animals given constant infusions and 6 animals given bolus 5-FU infusions into the hepatic artery. Six animals, which received normal saline infusion, served as controls. A second aim was to study possible pulmonary drug clearance. Aortic, pulmonary arterial, and coronary sinus plasma 5-FU concentrations were determined during constant and after the bolus infusions of 5-FU. The V5 ECG, aortic, pulmonary arterial, and right atrial pressures were recorded continuously, and cardiac output and coronary sinus blood flow were recorded intermittently in all animals. No significant alterations in hemodynamic variables were seen during constant infusion. After the bolus infusion, an increased arterio-mixed venous oxygen content difference was recorded. Pharmacokinetic data after 3-min infusions indicated pulmonary drug uptake and release; during constant infusions, the data indicated myocardial drug uptake. As there were no alterations in myocardial oxygen demand or supply or in systemic hemodynamics during this myocardial drug uptake, it is likely that the cardiotoxicity is related to the direct effects of the drug on cardiac myocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273420
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Red Sirius (1984)
    [s.l.] : Nature Publishing Group
    Nature 311 (1984), S. 8-8 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - The correspondence about Homer's wine-coloured sea reminds me about red Sirius. Several ancient authors call Sirius red, even though it is white with a slight bluish tint. This is another object which seems to have been called red even though blue would have been a better ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/311008c0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of acute zimeldine and alaproclate administration on the acquisition of two-way active avoidance: Comparison with other antidepressant agents, test of selectivity and sub-chronic studies (1984)
    Springer
    Psychopharmacology 84 (1984), S. 188-195 
    Details
    ISSN: 1432-2072
    Keywords: Zimeldine ; Alaproclate ; Antidepressants ; PCA ; Selectivity ; Subchronic administration ; Two-way ; One-way ; Avoidance ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The dose-dependent effect of acute zimeldine and alaproclate treatment upon the acquisition of two-way and one-way active avoidance in the rat was studied in a single-session and in a repeated-sessions design. Zimeldine (5–20 mg/kg, IP), but not alaproclate, caused disruptions of two-way avoidance acquisition. Acquisition deficits were also caused by citalopram and fluoxetine but not the other antidepressant drugs tested. Zimeldine, but not alaproclate or desipramine, caused a slight but non-significant impairment of one-way active avoidance; neither zimeldine nor alaproclate produced any effects upon fear conditioning and retention testing. The long-term action of p-chloroamphetamine (2×10 mg/kg) antagonised the acute zimeldine effect totally, and chronic treatment with zimeldine (15 days, 1×50 μmol/kg) and chlorimipramine (15 days, 2×10 μmol/kg) also caused some partial blockade of the two-way avoidance deficit. These data seem to suggest some involvement of serotonin (5-HT) in the observed disruptions of two-way active avoidance caused by acute zimeldine treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427444
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    Paper (German National Licenses)
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