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  • 1
    Electronic Resource
    Electronic Resource
    A pharmacokinetic study of the active metabolite of nabumetone in young healthy subjects and older arthritis patients (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 299-305 
    Details
    ISSN: 1432-1041
    Keywords: nabumetone ; rheumatoid arthritis ; pharmacokinetics ; old patients ; NSAID
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have performed a detailed pharmacokinetic study of the plasma concentrations of the major active metabolite of nabumetone, 6-methoxy-2-naphthylacetic acid (6 MNA), attained after a single dose and during chronic administration comparing the results of a group of young healthy volunteers with those of a group of elderly arthritic patients. The latter had higher peak plasma concentrations of 6MNA and slower rates of elimination but there is no tendency for the drug to accumulate unpredictably in the old. Disease activity also influences plasma concentration, those with more active disease, and lower serum albumin concentrations had lower AUC values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558163
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  • 2
    Electronic Resource
    Electronic Resource
    The Freshwater Eel Anguilla obscura Gunther, 1871, in Southern Africa (1957)
    [s.l.] : Nature Publishing Group
    Nature 180 (1957), S. 1216-1216 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In his revision of the genus Anguilla Shaw, Ege1 examined Gunther's type of obscura, and detailed specifications are available for identification of this species. The characteristics of this specimen from the Buffalo River system have been found to fall within the range of those given for Anguilla ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1801216a0
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  • 3
    Electronic Resource
    Electronic Resource
    Eels in Southern Africa (1957)
    [s.l.] : Nature Publishing Group
    Nature 180 (1957), S. 47-48 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] At night, during February and March 1957, upstream migrations of thousands of young eels, at all sizes from 10 to 22 cm., were observed in the Buffalo (27 30' E., 32 57' S.) and the Kariega Rivers (26 30' E., 33 23' S.). In samplings taken at this time from the Laing Dam wall on the Buffalo ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/180047b0
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  • 4
    Electronic Resource
    Electronic Resource
    Eels in Southern Africa (1959)
    [s.l.] : Nature Publishing Group
    Nature 184 (1959), S. 827-828 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Five species are represented: the two predominant African eels Anguilla nebulosa labiata Peters, and A. mossambica Peters, the widely distributed A. marmorata Quoy and Gaimard, and A. bicolor bicolor McClelland, and the rare A. obscura Gunther. Elvers of the two predominant eels reach the mainland ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/184827a0
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  • 5
    Electronic Resource
    Electronic Resource
    Treatment of psoriatic arthritis with sulphasalazine: A one year open study (1988)
    Springer
    Clinical rheumatology 7 (1988), S. 372-377 
    Details
    ISSN: 1434-9949
    Keywords: Psoriatic Arthritis ; Sulphasalazine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sulphasalazine (SASP) has recently become established as an effective treatment for active rheumatoid arthritis (RA), but has not previously been used in psoriatic arthritis in which remission-inducing drugs have proved disappointing. In this one year open study, 34 patients with active psoriatic arthritis were treated with sulphasalazine. An overall favourable clinical response was observed in 23 patients (67%). Nine patients (26%) achieved a very good therapeutic response and these either had arthritis associated with spondylitis or the symmetrical type of joint disease. Evaluation at 3,6 and 12 months showed a significant improvement in inflammatory indices including a reduction in the C-reactive protein level and ESR. The drug was well-tolerated and side-effects were mild. Eight patients (23.5%) stopped the drug because of reactions and one patient with a rash was successfully desensitised. Fifty-three percent continued the drug into the second year. No apparent exacerbation of the psoriasis was observed. These results suggest that sulphasalazine is a safe and potentially effective drug in the treatment of psoriatic arthritis. A double-blind placebocontrolled trial has been set up to determine its true efficacy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02239195
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  • 6
    Electronic Resource
    Electronic Resource
    Staining of demineralized cartilage (1981)
    Springer
    Histochemistry and cell biology 73 (1981), S. 385-390 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Demineralization of cartilage with alcoholic EDTA provides cartilage staining that is no better, as measured by scanning microdensitometry, than that of adequately fixed specimens demineralized with aqueous EDTA. Aqueous EDTA is a faster demineralizing agent than alcoholic EDTA. Certain fixatives can preserve maximal proteoglycan staining in articular cartilage even with subsequent rapid demineralization in formate buffer at pH 3.3. Although alcoholic formalin fixation provided optimum quantitative cartilage staining, cetylpyridinium chloride (CPC) in aqueous buffered formalin improved cellular detail, but CPC partially suppressed matrix staining.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00495653
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  • 7
    Electronic Resource
    Electronic Resource
    Staining of demineralized cartilage (1981)
    Springer
    Histochemistry and cell biology 73 (1981), S. 391-396 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Safranin O in the orthochromatic form stains articular cartilage proteoglycan quantitatively in histological sections of demineralized cartilage. This was shown by scanning microdensitometry of stained sections of undemineralized and demineralized articular cartilage and by biochemical analysis of 35S labelled cartilage subjected to demineralization. In constrast, Alcian Blue staining is affected by unknown factors other than simply the amount of proteoglycan present. Alcoholic formalin fixes articular cartilage proteoglycan more successfully than formol Zenker for subsequent rapid demineralization. Alcoholic formalin does not preserve cellular appearance as well as formol Zenker. Staining of articular cartilage with PAS appears unaffected by demineralization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00495654
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  • 8
    Electronic Resource
    Electronic Resource
    Endogenous sex steroid levels in women with generalised osteoarthritis (1991)
    Springer
    Clinical rheumatology 10 (1991), S. 316-319 
    Details
    ISSN: 1434-9949
    Keywords: Osteoarthritis ; Hormones ; Sex Hormone Binding Globulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Epidemiologic and clinical observations have suggested a relationship between generalised osteoarthritis (GOA) and hormonal and menopausal factors in women. We explored the hypothesis that postmenopausal women with GOA have altered sex hormone status compared with control women. We studied 112 women (mean age 64) with GOA. Controls were 151 women (mean age 54) from the general population without clinical evidence of hand or knee OA. All women were postmenopausal. Serum was assayed by RIA for testosterone, oestradiol, sex hormone binding globulin (SHBG), and dyhydroepiandrosterone sulphate (DHEAS). Because of the differences in mean ages, the results were compared according to equal age groups divided on the basis of tertiles. SHBG was lower in the GOA group, reaching significance in the middle group 53–61 years (58.0 vs 67.9nmol/l p〈0.05). Testosterone was slightly higher in GOA women aged under 53. No consistent differences were seen in the older age group or for the other sex steroids. These preliminary data suggest that middle-aged women with GOA have lower circulating SHBG levels. This implies that higher circulating free oestrogens and androgens are present suggesting a role in the aetiopathogenesis of GOA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208698
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  • 9
    Electronic Resource
    Electronic Resource
    A double-blind controlled study comparing sulphasalazine with placebo in rheumatoid factor (RF)-negative rheumatoid arthritis (1995)
    Springer
    Clinical rheumatology 14 (1995), S. 531-536 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Factor (RF)-negative ; Rheumatoid Arthritis ; Sulphasalazine ; Placebo Controlled Trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The efficacy and tolerability of sulphasalazine (SASP) was examined in a double blind, placebo-controlled 24-week study of 32 patients with rheumatoid factor (RF)-negative RA. Twelve patients (75%) of the SASP group completed the study; 4 patients were withdrawn because of an adverse event. Ten patients (62.5%) in the placebo group completed the study; 5 dropped out because of lack of response and one because of an adverse reaction. Efficacy was demonstrated by a significant and sustained improvement in the indices of disease activity in the SASP group. It was confirmed by significant intergroup differences in favour of SASP over placebo in the changes in ESR, Ritchie index, number of painful joints and clinical score. There was also a significant difference in favour of SASP in the number of responders and the number of withdrawals due to inefficacy. The character, frequency and timing of side-effects were similar to those previously reported. All were reversible on stopping therapy. This study shows that SASP is an effective second-line drug for treating patients with RF-negative RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208150
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  • 10
    Electronic Resource
    Electronic Resource
    The Outcome of Knee Synovitis in Early Arthritis Provides Guidelines for Management (2000)
    Springer
    Clinical rheumatology 19 (2000), S. 82-85 
    Details
    ISSN: 1434-9949
    Keywords: Key words:Knee synovitis – Monoarthritis – Outcome – Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The aim of the study was to examine the clinical outcome of patients presenting to an early arthritis clinic with synovitis of the knee. The patients were assessed at presentation for evidence and pattern of joint inflammation. These patients were then reassessed at 3, 6 and 12 months and thereafter annually to determine clinical outcome. One thousand six hundred and thirty-three consecutive referrals were examined, 903 of whom had early synovitis. One hundred and thirty had knee synovitis at presentation, of whom 73 fulfilled ACR criteria for rheumatoid arthritis (RA) during the study. All 73 presented with a symmetrical polyarthritis that included the small joints and had persistent disease at 1 year. Of the remaining 57 patients, 61% of those presenting with an oligoarthritis and 33% with a polyarthritis (including knee synovitis) were in remission at 1 year. None of those presenting as a monoarthritis of the knee had inflammation at 1 year or fulfilled ACR criteria for RA at any time. It was concluded that patients presenting with knee synovitis in the absence of a small joint polyarthritis usually have a benign course following standard therapy. No patient who presented with monoarthritis developed RA. Knee synovitis as part of a polyarthritis (even when not fulfilling ACR criteria) probably justifies disease-modifying antirheumatic drug at presentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100670050021
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