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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical characterization of HSP, α-MSH, Merkel cells and neuronal markers in acute UV dermatitis and acute contact dermatitis in vivo (1997)
    Springer
    Inflammation research 46 (1997), S. 409-411 
    Details
    ISSN: 1420-908X
    Keywords: Key words: HSP —α-MSH — Merkel cells — UV dermatitis — Contact dermatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: To study the immunoneurocrine network in inflammatory dermatoses, we investigated histochemically acute UV and acute contact dermatitis.¶Methods: Antibodies were applied to frozen and paraffin specimens of human skin after irradiation (n = 10), to positive patch tests (n = 10) and controls (n = 10) against: HSP 70, 72, 27, neuronal polypeptides (α-MSH, NSE, bombesin, PGP 9.5, NGF, NGF-R) and intermediate filaments (peripherin, NF 200, CK 19, 20).¶Results: HSPs and α-MSH were upregulated in UV dermatitis in the epidermis compared to contact dermatitis and normal skin. Sunburn cells did not express HSPs or α-MSH in UV dermatitis. Neuronal markers and HSP 27 labeled more nerve fibers in UV than in contact dermatitis, except the increased staining for NGF, NGF-R and α-MSH in nerve fibers in contact dermatitis. In UV dermatitis, 50% of Merkel cells were suprabasal, but in contact dermatitis, basal, rounded and reduced in number.¶Conclusions: Merkel cells, HSPs and markers of neuroinflammation are of different importance in UV and contact dermatitis in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050212
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  • 2
    Electronic Resource
    Electronic Resource
    Investigations on dark repair in various light sensitive inherited disorders (1970)
    Springer
    Human genetics 〈Berlin〉 9 (1970), S. 191-192 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Ein defekter “dark repair”-Mechanismus wurde bei 3 Fällen von Xeroderma pigmentosum (X.p.) bestätigt, während bei einem Fall von Bloom-Syndrom und 4 anderen lichtabhängigen Erbleiden der Haut normal funktionierende Repair-Enzyme gefunden wurden.
    Notes: Summary Defective dark repair is confirmed in 3 cases of Xeroderma pigmentosum while in one case of Bloom-syndrom and in 4 other light sensitive inherited disorders the mentioned enzyme system seems to be functional.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278935
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  • 3
    Electronic Resource
    Electronic Resource
    Nevoid basal cell carcinoma syndrome (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 218-218 
    Details
    ISSN: 1432-069X
    Keywords: Nevoid basal cell carcinoma syndrome ; Sister chromatid exchanges
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00456400
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  • 4
    Electronic Resource
    Electronic Resource
    Percutaneous penetration of hydroxyethylrutosides (1972)
    Springer
    European journal of clinical pharmacology 4 (1972), S. 182-184 
    Details
    ISSN: 1432-1041
    Keywords: Hydroxyethylrutosides ; percutaneous penetration ; thin layer-chromatography ; fluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Hydroxyethylrutosides (HR) were applied topically as a 2% gel to the skin of hairless albino mice and human volunteers. After various penetration times methanol-extractable constituents of HR were estimated by TL chromatography in separated samples of epidermis, connective tissue and subcutaneous fat. Tetrahydroxyethylrutoside accumulated in the epidermis. Trihydroxyethylrutoside, the major constituant of HR, passed quickly through the epidermal layers and appeared early and in relatively large quantities in dermal and subcutaneous tissues. Identical results were obtained in mouse and human skin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561143
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 333-336 
    Details
    ISSN: 1432-1041
    Keywords: Garlic ; Platelet aggregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A platelet-inhibiting effect is described for garlic. In this double-blind, placebo-controlled study on 60 voluntary subjects with cerebrovascular risk factors and constantly increased platelet aggregation it was demonstrated that the daily ingestion of 800 mg of powdered garlic (in the form of coated tablets) over 4 weeks led to a significant inhibition of the pathologically increased ratio of circulating platelet aggregates and of spontaneous platelet aggregation. The ratio of circulating platelet aggregates decreased by 10.3%, from 1.17±0.08 to 1.05±0.11 (P〈0.01), and spontaneous platelet aggregation by 56.3%, from 40.7±23.3 to 17.8±23.2 degrees (P〈0.01) during the garlic phase. There were no significant changes in the placebo group. The parallel group comparison (garlic versus placebo) revealed a significantly different ratio of circulating platelet aggregates after 4 weeks of treatment (P〈0.05). After the 4-week wash-out phase the values increased again to 1.19±0.32 and 34.9±28.7°, reaching the initial values (run-in phase prior to the ingestion of garlic). Since garlic is well tolerated it would be worth testing it in a controlled clinical trial for usefulness in preventing disease manifestations associated with platelet aggregation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265950
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  • 6
    Electronic Resource
    Electronic Resource
    The Study of Secondary Electrons and Redistributed Primaries (Electrons and Positrons) from Ge(100) Surface Utilizing the Electron and the Positron Beams (1997)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 255-257 (Sept. 1997), p. 708-710 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/02/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.255-257.708.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Measurement of Positron Work Function, Positronium Fraction and PAES Intensities from GaAs(100) (1997)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 255-257 (Sept. 1997), p. 638-640 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/02/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.255-257.638.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Microinjection of an antibody against HSP 72 in keratinocytes to study acute UV injury〈link href="#fn1"〉⊃〈/link〉 (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 8 (1999), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: First, a method of microinjection of antibodies in primary human keratinocytes in culture was established. Second, in acute UV irradiation, the physiological role of heat shock protein (HSP) 72 in keratinocytes was studied with this method. Primary human keratinocytes in culture were injected with “controls” as fluorescent dyes, phosphate buffered saline (PBS), an irrelevant secondary antibody and an antibody against a protein with known protective function in UV erythema, HSP 72. UV irradiation was applied and survival, colony forming and immunohistochemistry for injected and non-injected keratinocytes were evaluated in a time course. Puncturing the plasma membrane with injections of “controls” as FITC, PBS and the IgG anti-mouse antibody did not result in reflux of injected material or any alteration in morphology or colony-forming ability for 24 h. Keratinocytes injected with an mAb to HSP 72 without UV irradiation survived microinjection for up to 12 days, while surprisingly, more than double of injected and irradiated ones died after 12 h compared to not injected and irradiated ones. Moreover, microinjection of the antibody to HSP 72 in the nucleus resulted in a loss of the immunohistochemical labeling for HSP 72 in these cells after 12 h. Microinjection of the “controls” did not harm the survival, forming of colonies and expression of HSP 72 in keratinocytes for 24 h. In contrast, microinjection of an mAb against HSP 72 led to an increase in cell death after UV irradiation, confirming that HSP 72 is important for UV protection. Microinjection of antibodies in human keratinocytes in culture might allow the study of the physiological role of some proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1999.tb00378.x
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  • 9
    Electronic Resource
    Electronic Resource
    Charge-transfer effect on surface-enhanced second-harmonic generation (1993)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 97 (1993), S. 5080-5084 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100121a039
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  • 10
    Electronic Resource
    Electronic Resource
    An Investigation of the Rheological Properties of 10 Vinyl-Polysiloxane Impression Materials (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of prosthodontics 2 (1993), S. 0 
    Details
    ISSN: 1532-849X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Purpose The time required for 10 vinyl-polysiloxane impression materials to reach a viscosity of 5000 poise (Tcv) was estimated. This viscosity was selected based on previous work that suggested that an impression material might not be workable if its viscosity exceeded this limit. The effect of variations in the time of placement of the impression materials into a simulated oral-temperature environment was also studied.Materials and Methods The change in the viscosity of the impression materials was recorded with a viscometer at oral temperature. Impression materials were placed at either 20 seconds, 30 seconds, or 40 seconds from the start of mixing.Results There were statistically significant differences in Tcv among various impression materials. Variations in placement time significantly affected the Tcv of six impression materials.Conclusions Knowledge of the viscosity change of an impression material is beneficial in the clinical selection of an impression material.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1532-849X.1993.tb00402.x
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