Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Ionic titanocene complexes: a new type of antitumor agent (1989)
    Springer
    Cancer chemotherapy and pharmacology 24 (1989), S. 23-27 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five ionic cyclopentadienyltitanium(IV) derivatives were investigated for their activity against fluid Ehrlich ascites tumor. Four compounds were built up by the intact bis(cyclopentadienyl)titanium(IV) (“titanocene”) unit, forming the cationic moiety together with two covalently bound ligands, with certain anions being bonded via electrostatic forces: the acetonitrile complex [(C5H5)2TiCl(NCCH3)]+[FeCl4]- (I), the 2,2′-bipyridyl derivative [(C5H5)2Ti(bipy)]2+[CF3SO3]2 (II), the o-phenanthroline complex [(C5H5)2Ti(phen)]2+[CF3SO3]2 (III), and the N-methyl-o-aminothiophenolate derivative {(C5H5)2Ti[o-S(NHCH3)C6H4]}+I- (IV). Another ionic cyclopentadienyltitanium derivative investigated was the five-coordinate bis(dithiolene) chelate [(C5H5)Ti(1,2,4-S2C6H3CH3)2]-[N(C2H5)4]+ (V), the cyclopentadienyltitanium moiety representing the anionic part of the complex salt. All complexes were ionic, salt-like compounds, distinguished by good water solubility. Whereas complexes I, III, and V, given at optimal dose levels, effected maximal cure rates of only 70%–80%, all animals were cured after receiving complexes II and IV at dose ranges of 200–220 and 240–300 mg/kg, respectively. The antitumor activity of complex I was confirmed against solid experimental tumor systems B16 melanoma, colon 38 carcinoma, and Lewis lung carcinosarcoma. Because of their improved solubility in water and pronounced antitumor activity (especially that of II and IV against fluid Ehrlich ascites tumor), ionic cyclopentadienyl titanium complexes are considered to be an interesting new type of antitumor agent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254100
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Tumorhemmung durch Metallocene: Wirkung von Titanocen-, Zirconocen- und Hafnocen-dichlorid gegenüber Ehrlich-Aszites-Tumor der Maus (1980)
    Springer
    Journal of cancer research and clinical oncology 96 (1980), S. 43-51 
    Details
    ISSN: 1432-1335
    Keywords: Titanocene dichloride ; Zirconocene dichloride ; Hafnocene dichloride ; Antitumor activity ; Ehrlich ascites tumor ; Titanocen-dichlorid ; Zirconocen-dichlorid ; Hafnocen-dichlorid ; Tumorhemmende Aktivität ; Ehrlich-Aszites-Tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Antitumor-Aktivität der Metallocen-dichloride TDC, ZDC und HDC wird an Ehrlich-Aszites-Tumor-tragenden CF 1-Mäusen untersucht. Nach einmaliger i.p.-Injektion von TDC in optimaler Dosis (30–60 mg/kg) 24 h p.t.t. überleben 80–90% der Tiere bis zum 180. Tag p.t.t. ohne Tumormanifestation. Dies bedeutet eine Zunahme der mittleren Überlebensdauer um etwa 900% gegenüber den unbehandelten Kontrolltieren. ZDC und HDC hingegen weisen unter gleichen Versuchsbedingungen keine erkennbaren tumorhemmenden Eigenschaften auf. Nimmt man einen ähnlichen Wirkungsmechanismus für DDP und die cancerostatisch aktiven Metallocen-dichloride TDC, VDC und MDC an, so kann der deutlich größere nicht-bindende Cl... Cl-Abstand (“bite”) von ZDC und HDC mit der cancerostatischen Unwirksamkeit der letztgenannten Verbindungen in Zusammenhang gebracht werden.
    Notes: Summary The antitumor activity of the metallocene dichlorides TDC, ZDC, and HDC against Ehrlich ascites tumor in CF 1 mice is investigated. A single i.p. injection of TDC in the optimum dose (30–60 mg/kg) 24 h p.t.t. achieves survival of 80–90% of the animals until day 180 p.t.t. without any tumor manifestation. This indicates an increase in the mean survival time of about 900% referred to the untreated animals. In contrast, ZDC and HDC exhibit no recognizable antineoplastic properties under equal experimental conditions. Assuming a similar mechanism of tumor inhibition for both DDP and the antineoplastic active metallocene dichlorides TDC, VDC, and MDC, the comparatively increased non-bonding Cl... Cl distance (“bite”) of ZDC and HDC may be responsible for the cancerostatic inactivity of the latter compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412896
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Tumor inhibition by metallocenes: Antitumor activity of titanocene dihalides (C5H5)2TiX2 (X=F, Cl, Br, I, NCS) and their application in buffered solutions as a method for suppressing drug-induced side effects (1980)
    Springer
    Journal of cancer research and clinical oncology 97 (1980), S. 31-39 
    Details
    ISSN: 1432-1335
    Keywords: Titanocen-dihalogenide ; Tumorhemmende Aktivität ; Ehrlich-Aszites-Tumor ; Unterdrückung von Nebenwirkungen ; Titanocene dihalides ; Antitumor activity ; Ehrlich ascites tumor ; Suppression of side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The antitumor activity of titanocene dihalides (C5H5)2TiX2 with X=F, Cl, Br, I, NCS is investigated against Ehrlich ascites tumor in CF 1 mice. Varying doses of the compounds are applied as single i.p. injections 24 h pt.t. both in non-buffered (pH 1.4–3.9) and buffered (pH 4.2–5.9) solutions or suspensions, all of the substances achieving in optimum doses cure rates of 100% on day 120 p.t.t. This corresponds to I.L.S. values of 600–750% referred to the untreated controls. Some drug-induced side effects, especially the appearance of postperiotonitic symptoms several weeks after i.p. application of higher doses of titanocene dihalides, are strikingly reduced by pH elevation in the injected drug solutions.
    Notes: Zusammenfassung Die tumorhemmende Wirksamkeit von Titanocen-dihalogeniden (C5H5)2TiX2 mit X=F, Cl, Br, J, NCS wird an Ehrlich-Aszites-Tumor-tragenden CF 1-Mäusen untersucht. Verschiedene Dosen der Substanzen werden 24 h p.t.t. als einmalige i.p.-Injektionen sowohl in ungepufferten (pH 1.4–3.9) als auch in gepufferten (pH 4.2–5.9) Lösungen bzw. Suspensionen appliziert. Mit allen Verbindungen werden in optimaler Dosis Heilungsraten von 100% am 120. Tag p.t.t. erreicht. Dies entspricht Verlängerungen der mittleren Überlebensdauer (I.L.S.-Werte) um 600–750% gegenüber den unbehandelten Kontrolltieren. Einige substanzbedingte Nebenwirkungen, insbesondere das Auftreten postperitonitischer Symptome mehrere Wochen nach i.p.-Applikation höherer Dosen der Titanocen-dihalogenide, werden durch pH-Erhöhung in den Injektionslösungen deutlich zurückgedrängt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411276
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Zur kristallmorphologischen Eiweisstestung von Samen (1964)
    Springer
    Cellular and molecular life sciences 20 (1964), S. 54-56 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The method of sensitive copper II-chloride crystallization has proved to be suitable for tests with biological protein substances. Seed and parts of seed taken from Leguminosae and Gramineae were tested. These two botanical families form typical and reproducible crystal patterns of cupric chloride.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02146043
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Ferricenium complexes: A new type of water-soluble antitumor agent (1984)
    Springer
    Journal of cancer research and clinical oncology 108 (1984), S. 336-340 
    Details
    ISSN: 1432-1335
    Keywords: Iron compounds ; Ferricenium complexes ; Antitumor activity ; Ehrlich ascites tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antitumor activity of a series of iron complexes, i.e., of ferrocene [Cp2Fe], of tetrachloroferrates(III) [R4N]+[FeCl4]-, and of ferricenium complexes [Cp2Fe]+X- (X-=[FeCl4]-, 1/2[Cl3FeOFeCl3]2-, [H5Mo7O24]-·2H2O, [2,4,6-(NO2)3C6H2O]-, or [CCl3COO]-·2 CCl3COOH) was investigated against EAT in CF1 mice. Whereas ferrocene and the ammonium tetrachloroferrates(III) did not show recognizable tumor-inhibiting activity, such activity was exhibited by the water-soluble, salt-like ferricenium complexes; the best antineoplastic properties, with optimum cure rates of 100%, were found for ferricenium picrate and ferricenium trichloroacetate. The ferricenium compounds are the first iron complexes for which antineoplastic activity has now been shown. They represent a new type of antitumor agent insofar as they differ fundamentally from known inorganic and organometallic antitumor agents (a) by their ionic, salt-like character, which is responsible for their high water solubility, and (b) by the absence of a cis-dihalometal moiety; this moiety has been recognized as important for the intracellular action of other known inorganic cytostatics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390468
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Tumor inhibition by titanocene dichloride: First clues to the mechanism of action (1980)
    Springer
    Naturwissenschaften 67 (1980), S. 415-416 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405494
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Different inhibition pattern of the nucleic acid metabolism (1981)
    Springer
    Naturwissenschaften 68 (1981), S. 272-273 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01047337
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Neue Titanocen-Derivate mit Thiokresolatliganden (1988)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 560 (1988), S. 163-168 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: New Titanocene Derivatives with Thiocresolate LigandsOn reaction of titanocene dichloride (Cp2TiCl2; Cp = η5-C5H5) with NaSC6H4CH3-o or LiSC6H4CH3-p in toluene/benzene or in pure benzene at room temperature, one chloride ligand is substituted to give Cp2TiCl(SC6H4CH3-o) (I) or Cp2TiCl(SC6H4CH3-p) (II) respectively. Analogously, from Cp2Ti(Cl)CH3 Cp2TiCH3(SC6H4CH3-o) (III) or Cp2TiCH3(SC6H4CH3-p) (IV) is formed. By, substitution of both chloride ligands, the bis(thiocresolato) complexes Cp2Ti(SC6H4CH3-o)2 (V) Cp2Ti(SC6H4CH3-m)2 (VI) and Cp2Ti(SC6H4CH3-p)2 (VII) could be prepared from the corresponding thiocresols in ether using triethylamine as supporting base. The substances were characterized by i.r., 1H n.m.r., and mass spectra.
    Notes: Titanocen-dichlorid (Cp2TiCl2; Cp = η5-C5H5) reagiert mit NaSC6H4CH3-o oder LiSC6H4CH3-p in Toluol/Benzol oder reinem Benzol bei Raumtemperatur unter Substitution eines Chlorid-Liganden zu Cp2TiCl(SC6H4CH3-o) (I) bzw. Cp2TiCl(SC6H4CH3-p) (II). In analoger Reaktionsführung bildet sich aus Cp2Ti(Cl)CH3 Cp2TiCH3(SC6H4CH3-o) (III) bzw. Cp2TiCH3(SC6H4CH3-p) (IV). Die unter Substitution beider Chlorid-Liganden erhaltenen Bis(thiokresolato)-Komplexe Cp2Ti(SC6H4CH3-o)2 (V), Cp2Ti(SC6H4CH3-m)2 (VI) und Cp2Ti(SC6H4CH3-p)2 (VII) konnten aus den entsprechenden Thiokresolen mit Triethylamin als Hilfsbase in Ether dargestellt werden. Alle Substanzen wurden IR-, 1H-NMR- sowie massenspektrometrisch charakterisiert.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19885600120
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Cycloheptaschwefel, S7, und Cyclodekaschwefel, S10 - zwei neue Schwefelringe (1968)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 80 (1968), S. 660-660 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19680801604
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Ein Tetrasulfid-Chelat des Molybdäns (1969)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 81 (1969), S. 332-333 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19690810912
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...