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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 38 (1990), S. 609-615 
    ISSN: 1432-1041
    Keywords: Terguride ; partial dopamine agonist ; pharmacokinetics ; endocrine effects ; pituitary hormones ; 6β-OH cortisol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma levels of the partial dopamine agonist, terguride, were measured by RIA in healthy volunteers after a single i. v. dose of 50 μg and on the first and seventh day of an oral treatment with 250 μg, 500 μg and 750 μg b. d. Basal and releasing hormone (TRH, GHRH, CRF, LHRH) — stimulated pituitary hormone secretion (PRL, TSH, GH, FSH, LH) and cortisol were also determined by RIA. Following the i. v. injection, plasma terguride levels declined biphasically, with half-lives of 0.2 and 1.5 h; total clearance was 17 ml·min−1·kg−1. the oral bioavailability of terguride over all doses was about 20%. Basal and TRH-stimulated prolactin levels were dose-dependently depressed, but the secretion of other hormones remained unaffected. Tolerance of terguride was excellent and there was no negative effect on performance or mood, nor on mixed-function oxygenase activity, assessed as urinary 6β-OH cortisol.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 38 (1990), S. 71-75 
    ISSN: 1432-1041
    Keywords: Rolipram ; enantiomers ; pharmacokinetics ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma levels of S-(+)-rolipram and R-(−)-rolipram in six healthy male volunteers were measured by radioimmunoassay after intravenous injection of 0.1 mg and oral administration of 1.0 mg of the pure enantionmers. Following i.v. treatment, plasma levels of both isomers declined in three phases, with half-lives of 0.2 h, 0.6–0.9 h and 6–8 h. Total clearance was 6 ml · min−1 · kg−1. Oral administration of 1.0 mg gave a peak concentration of 16 ng · ml−1 after 0.5 h. Bioavailability of (+)-rolipram was 77% and of the (−) enantiomer it was 74%. There was no significant difference in Cmax, half-life, total clearance or bioavailability between the two enantiomers.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1041
    Keywords: Lisuride ; pharmacokinetics ; prolactin concentrations ; healthy volunteers ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma concentration of lisuride and prolactin have been measured in twelve healthy male volunteers after IV, IM or SC injection of 25 μg lisuride hydrogen maleate as an aqueous solution. After IV administration the plasma lisuride fell in two phases with half-lives of 14 min and 1.5 h. Total clearance was 13 ml·min−1·kg−1. After IM and SC injection the plasma concentrations peaked at 12 to 15 min and the profiles were similar to that found after IV administration. The systemic availabilities were 90% and 94%, respectively. Prolactin concentrations were reduced by a maximum of 60% relative to the normal circadian rhythm after all three routes of administration. The treatments were well tolerated, the only adverse reactions reported by some of the volunteers being mild, transient dizziness, tiredness, and nausea.
    Type of Medium: Electronic Resource
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  • 4
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    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 18:11 (1970) 1412 
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  • 5
    facet.materialart.
    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 32:4 (1984) 358 
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  • 6
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    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Orientalistische Literaturzeitung. 35 (1932) 711 
    ISSN: 0030-5383
    Topics: Linguistics and Literary Studies , Ethnic Sciences , History
    Notes: Besprechungen
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  • 7
    ISSN: 1435-1803
    Keywords: coronary conductance artery ; coronary spasm ; serotonin antagonist ; phentolamine ; nadolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Wirkung intravenöser Infusionen von Ergonovitartrat (0.05–20 μg/kg/min, 12 Minuten Dauer) auf die Koronararterien wurde in 14 wachen Hunden untersucht. Die Tiere waren für eine kontinuierliche Messung des Gefäßdurchmessers mit einem Ultraschall-Verfahren mittels implantierten piezoelektrischen 10-MHz-Kristallen ausgerüstet. Ergonovin verursachte eine biphasische Koronarreaktion: eine geringgradige, vorübergehende Dilatation während der ersten Minuten der Infusion, anschließend eine allmählich einsetzende Konstriktion, die ihr Maximum erst 5–15 Minuten nach Ende der Infusion erreichte und für mindestens 10 Minuten bestehen blieb. Die Schwellendosis für signifikante Konstriktion betrug 0,05 μg/kg/min. Die Dosis von 5 μg/kg/min (kumulativ 60 μg/kg, was 35 μg/kg Ergonovin-Maleat entspricht) verursachte eine Abnahme des mittleren Durchmessers der linken umschlingenden Koronararterie um 137±15 μm (=4,6%) ohne signifikante Wirkungen auf Herzfrequenz, Plasma-Katecholamine oder Plasma-Renin-Aktivität. Die koronarvenöse O2-Sättigung nahm nicht ab, demnach erfolgte also keine Konstriktion von koronaren Widerstandsgefäßen. Die Konstriktion der epikardialen Gefäße war nicht durch einen Vasopressin-Antagonisten abschwächbar. Unter adrenerger Blockade (2 mg/kg Phentolamin und 2 mg/kg Nadolol) oder unter Ganglienblockade (5 mg/kg Pentoliniumtartrat) verursachte Ergonovin (5 μg/kg/min) eine erhebliche Zunahme des arteriellen Mitteldruckes, während die Verminderung des Koronararterien-Durchmessers abgeschwächt war. Wurde dieser arterielle Druckanstieg durch entsprechende Blutentnahme verhindert, so war die Ergonovin-induzierte Koronarkonstriktion weder durch adrenerge Blockade noch durch Ganglienblockade abgeschwächt. Der Serotonin-Antagonist Methysergid (0,5 mg/kg) hob die ergonovininduzierten Koronarreaktionen vollständig auf. Ergonovin verursacht in Hunden eine Konstriktion epikardialer Koronararterien ähnlich der diffusen Koronarverengung in Menschen, die nicht an “Variant”-Angina-pectoris leiden. Diese Konstriktionen werden nicht durch einen adrenergen Mechanismus bewirkt.
    Notes: Summary The effect of i.v. ergonovine tartrate infusions (0.05–20 μg/kg/min, 12 minutes duration) on coronary arteries was studied in 14 conscious dogs instrumented to continuously measure vascular diameter by an ultrasonic dimension gauge using 10-MHz piezoelectric crystals. Ergonovine induced a biphasic coronary response: small, transient dilation during the first minutes of infusion, followed by slowly developing constriction reaching its maximum 5 to 15 minutes after the end of the infusion and persisting at this level for at least 10 minutes. The threshold dosage for significant constriction was 0.05 μg/kg/min. A dosage of 5 μg/kg/min (cumulative 60 μg/kg, corresponding to 35 μg/kg ergonovine maleate) caused a decline in mean left circumflex artery diameter by 137±15 μm (=4.6%) without significantly altering heart rate, plasma catecholamines or plasma renin activity. Coronary venous O2 saturation did not decline, indicating the absence of coronary resistance vessel constriction. The epicardial artery constriction was not attenuated by a vasopressin antagonist. Under adrenergic blockade (2 mg/kg phentolamine and 2 mg/kg nadolol) or under ganglionic blockade (5 mg/kg pentolinium tartrate), ergonovine (5 μg/kg/min) caused substantial elevation in mean arterial pressure, while the decline in coronary artery diameter was attenuated. When this increase in arterial pressure was prevented by appropriate bleeding, the ergonovine-induced coronary constriction was not diminished by adrenergic or ganglionic blockade. The serotonin antagonist methysergide (0.5 mg/kg) completely abolished the ergonovine-induced coronary artery vasomotion. It is concluded that ergonovine in dogs causes an epicardial coronary artery constriction comparable to the diffuse coronary artery narrowing in men not suffering from variant angina pectoris. These constrictions are not mediated by an adrenergic mechanism.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Tropical animal health and production 14 (1982), S. 205-206 
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Tropical animal health and production 14 (1982), S. 167-171 
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé 2090 foies de boeufs de boucherie du Nord-Ouest de l'Argentine ont été inspectés dans un important abattoir de la province de Salta; 13 p. 100 ont été trouvés porteurs de lésions de fasciolose, qui ont été classées en fonction de leur gravité—182 d'entre eux, soit 67,2 p. 100 étaient légèrement atteints, 77 soit 28,4 p. 100, l'étaient modérément et seulement 12 (4,4 p. 100) l'étaient gravement. A l'occasion d'une enquête effectuée sur le terrain, 85 animaux, surtout âgés entre 6 et 18 mois, ont été abattus et 12 (14 p. 100) étaient porteurs de lésions de fasciolose. L'influence deFasciola hepatica sur les gains de poids du bétail de boucherie a été étudiée dans deux fermes. Les animaux infectés ont été répartis en deux groupes et un groupe a été mensuellement traité. Dans une ferme seulement les animaux étaient constamment exposés à l'infection. Aucune différence, dans les gains de poids n'a été observée après, respectivement, 7 et 14 mois par comparaison avec les animaux témoins non traités. En conclusion si la fasciolose est largement répandue chez le bétail de boucherie elle n'a qu'une influence limitée sur la production de viande.
    Abstract: Resumen Se inspeccionaron 2.090 hígados en un camal en el Noroccidente de Argentina, en la Provincia de Salta; el 13% se encontró con lesiones de fascioliasis, las cuales se clasificaron de acuerdo a la severidad de las mismas. De los hígados decomisados 182 (67·2%) tenían lesiones ligeras, 77 (28·4%) moderadas y solamente 12 (4·4%) severas. En un trabajo de campo, se sacrificaron 85 animales entre 6 y 18 meses de edad, encontrándose 12 de ellos (14%) con lesiones de fascioliasis. Se investigó la influencia deFasciola hepatica en la ganancia de peso de ganado para engorde en 2 haciendas diferentes. Los animales infectados se dividieron en 2 grupos, tratándose uno de ellos con drogas específicas. Solamente en 1 de las haciendas, los animales estaban expuestos continuamente a la infección. No se encontraron diferencias en peso a los 7 y 14 meses respectivamente, cuando se compararon los tratados y controles. Se concluyó entonces, que la enfermedad se encuentra difundida, pero los niveles de infección son bajos actualmente para causar pérdidas económicas.
    Notes: Summary Two thousand and ninety beef cattle livers from north-west Argentina were inspected at a large slaughterhouse in Salta; 13% were found to have lesions of fascioliasis and these were classified according to their severity. Of the livers condemned 182 (67·2%) were lightly affected, 77 (28·4%) moderately affected and only 12 (4·4%) severely affected. In a field survey 85 animals, mainly between 6 and 18 months old, were slaughtered and 12 (14%) had lesions of fascioliasis. The influence ofFasciola hepatica on weight gain in beef cattle was assessed on 2 farms. Infected animals were divided into 2 groups and 1 group was treated monthly. Only on 1 farm were the animals exposed continuously to infection. No differences in weight gain were found over 7 and 14 months respectively when compared to untreated controls. It was concluded that fascioliasis is widespread but at a low level in beef cattle.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Tropical animal health and production 14 (1982), S. 207-215 
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Neufs fermes ont été régulièrement visitées pendant un an, de 1979 à 1980, dans la province de Salta, en Argentine subtropicale. A chacune des visites effectuées, une nécropsie a été pratiquée et des échantillons de fèces et de sang ont été récoltés d'autres animaux principalement âgés de 6 à 18 mois—90 nécropsies ont été ainsi pratiquées et près de 1500 échantillons fécaux récoltés. L'helminthose gastro-intestinale était plus répandue et plus sévère en automne lorsque les veaux étaient âgés d'environ 9 mois, suivie par une chute drastique du nombre de vers à la fin de l'hiver. Des helminthes ont été trouvés dans d'autres organes, sans présenter d'importance. Aux périodes majeures, 20 p. 100 des animaux ont présenté un décompte d'oeufs supérieur à 750 et hébergeaient plus de 1000Haemonchus. Cette espèce a été considérée comme la plus importante mais les autres espèces les plus fréquemment rencontrées ont étéOesophagostomum Cooperia etTrichostrongylus spp. La liste de toutes les espèces rencontrées est donnée. Des veaux traceurs ont été utilisés pour déterminer les périodes d'infestation. Aucune hypobiose n'a été rencontrée. Il est conclu que la réduction marquée constatée dans le nombre d'oeufs après le pic automnal est due au développement de l'immunité chez la majorité des jeunes animaux.
    Abstract: Resumen Se visitaron regularmente 9 haciendas ganaderas durante un año 1979–1980, en la Provincia de Salta, Argentina. Se hizo 1 necropsia durante cada visita, y se tomaron muestras de sangre y fecales de otros animales de edades comprendidas entre 6 y 18 meses. Se hicieron en total 90 necropsias y se colectaron aproximadamente 1.500 muestras fecales. La helmintiasis gastro-intestinal fue más severa en otoño cuando los terneros tenían 9 meses de edad. seguido de un descenso en el número de parásitos hacia el final del invierno. En períodos críticos el 20% de los animales tenían conteos de huevos de más de 750 hpg y más de 1.000Haemonchus. Esta especie se consideró la más importante, pero también se encontraronOesophagostomum, Cooperia yTrichostrongylus spp. El trabajo presenta una lista de todos los parásitos encontrados. Terneros centinelas se utilizaron para determinar los períodos de infestación. No se encontró hipobiosis. Se concluye, que el descenso marcado en el número de parásitos en los bovinos jóvenes después del otoño, se debe al desarrollo de inmunidad en la mayoría de los animales.
    Notes: Summary Nine farms were each visited regularly for a year in 1979 and 1980 in Salta Province in the subtropics of Argentina. A necropsy was done at each visit and faecal and blood samples were taken from other animals mostly aged between 6 and 18 months. Ninety necropsies were done and nearly 1,500 faecal samples collected. Gastro-intestinal helminthiasis was most general and severe in autumn when calves were about 9 months old and this was followed by a dramatic fall in numbers of worms by the end of winter. Helminths were found in other organs but were not considered important. At peak periods 20% of the animals had worm egg counts of more than 750 epg and contained more than 1,000Haemonchus worms. This species was considered to be the most important but other frequently encountered species wereOesophagostomum, Cooperia andTrichostrongylus spp. A list is given of all species found. Tracer calves were used to determine the periods of infestation. No hypobiosis was encountered. It was concluded that the sharp fall in numbers of worms after the autumn peak was due to the development of immunity by the majority of the young animals.
    Type of Medium: Electronic Resource
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