ISSN:
1460-9592
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The conditions for intubation were studied in 28 infants (age 1–14 months, ASA I/II) after intravenous administration of propofol or atracurium. Anaesthesia was induced via mask with halothane and N2O/O2. The study propofol group (GrP, n= 14) received a bolus of propofol 3.0 mg·kg−1, whilst the control atracurium group (GrA, n= 14) received atracurium 0.4 mg·kg−1. Intubation conditions were listed as excellent, moderate or impossible in GrP 79%–14%−7% and in GrA 72%–14%–14% respectively. A decrease of mean arterial pressure (GrP–9.17 ± 10.8 mmHg, −13% GrA–9.67 ± 15.2 mmHg, −12%) and heart rate (GrP–18 ± 21 bpm; GrA–14 ± 23 bpm) were seen after induction with halothane. After intubation the mean arterial pressure increased. The increase of heart rate observed after intubation was higher in GrA (GrP +6 ± 8 bpm; GrA +17 ± 19 bpm). The same intubation scores found with propofol in comparison with atracurium may be due to the reflex-suppressive and stress-inhibitory effect of propofol. Since excellent conditions for intubation were found with comparable smaller effects on measured haemodynamic parameters, propofol is regarded as a safe alternative to atracurium to facilitate intubation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1460-9592.1993.tb00052.x
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