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  • 1
    Electronic Resource
    Electronic Resource
    11β hydroxysteroid dehydrogenase type 2 enzyme is expressed in normotensive and hypertensive patients with renal disease (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 4 (1998), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY: The enzyme 11β hydroxysteroid dehydrogenase type 2 (11βHSD2) converts glucocorticoids to their 11-keto metabolites, permitting binding of aldosterone to the non-selective mineralocorticoid receptor. Recent studies have suggested that 11βHSD deficiency may be implicated in essential hypertension and renal disease. Using an antibody against a peptide deduced from the cDNA sequence, the renal expression of 11βHSD2 was examined in patients with advanced stages of renal disease and associated hypertension, patients with primary hypertension resulting in renal damage, and patients with preserved or mildly damaged renal architecture without concomitant hypertension. Despite variable degrees of tubulointerstitial damage, 11βHSD2 was expressed in distal convoluted tubules and collecting ducts in all patient groups. Collapsed tubules retained strong immunoreactivity, but decreased staining was apparent in dilated tubules. There was weak staining of the thick ascending limb of Henle. Variable glomerular expression of 11βHSD2 was observed. Our results therefore suggest that absence of renal 11βHSD2 is not a prominent feature of hypertensive nephrosclerosis, or primary renal disease associated with hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.1998.tb00325.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    11β hydroxysteroid dehydrogenase type 2 enzyme is expressed in normotensive and hypertensive patients with renal disease (1998)
    Oxford, UK : Blackwell Science Ltd
    Nephrology 4 (1998), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The enzyme 11β hydroxysteroid dehydrogenase type 2 (11βHSD2) converts glucocorticoids to their 11-keto metabolites, permitting binding of aldosterone to the non-selective mineralocorticoid receptor. Recent studies have suggested that 11βHSD deficiency may be implicated in essential hypertension and renal disease. Using an antibody against a peptide deduced from the cDNA sequence, the renal expression of 11βHSD2 was examined in patients with advanced stages of renal disease and associated hypertension, patients with primary hypertension resulting in renal damage, and patients with preserved or mildly damaged renal architecture without concomitant hypertension. Despite variable degrees of tubulointerstitial damage, 11βHSD2 was expressed in distal convoluted tubules and collecting ducts in all patient groups. Collapsed tubules retained strong immunoreactivity, but decreased staining was apparent in dilated tubules. There was weak staining of the thick ascending limb of Henle. Variable glomerular expression of 11βHSD2 was observed. Our results therefore suggest that absence of renal 11βHSD2 is not a prominent feature of hypertensive nephrosclerosis, or primary renal disease associated with hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.1998.d01-19.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    VASCULAR LOCALIZATION OF THE 11β-HYDROXYSTEROID DEHYDROGENASE TYPE II ENZYME (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 23 (1996), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The enzyme 11β-hydroxysteroid dehydrogenase type II (11βHSD2) confers specificity on the non-specific mineralocorticoid receptor by converting cortisol to cortisone.2. We have examined the localization of this enzyme in the human skin, myocardium and saphenous vein by immuno-histochemical techniques.3. High amounts of 11βHSD2 immunoreactivity were found in smooth muscle cells in the arterioles of the skin, heart and saphenous vein. Lower amounts of staining were also found in longitudinal and concentric smooth muscle cells lining the lumen of the saphenous vein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1996.tb02776.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    High-affinity anti-oestrogen binding site distinct from the oestrogen receptor (1980)
    [s.l.] : Nature Publishing Group
    Nature 288 (1980), S. 273-275 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Our evidence comes from comparison of the concentrations of high-affinity, saturable binding sites for oestradiol and anti-oestrogens in the same cytosol preparations, and from competition experiments with tritiated anti-oestrogens. Typical results of saturation analysis experiments with ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/288273a0
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Type II 11β-Hydroxysteroid Dehydrogenase Expression in Human Colonic Epithelial Cells of Inflammatory Bowel Disease (1999)
    Springer
    Digestive diseases and sciences 44 (1999), S. 2516-2522 
    Details
    ISSN: 1573-2568
    Keywords: TYPE II 11β-HYDROXYSTEROIDDEHYDROGENASE ; ULCERATIVE COLITIS ; CROHN'S DISEASE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Type II 11β-hydroxysteroid dehydrogenaseendows specificity on the mineralocorticoid receptor bymetabolizing cortisol and regulates sodium absorption inrenal and colonic epithelium. Altered expression of this enzyme may be associated with impairedsodium absorption often seen in colonic mucosa ofinflammatory bowel disease. The aim of this study was toinvestigate possible abnormality of11β-hydroxysteroid dehydrogenase protein and mRNA expression ininflammatory bowel disease. In Crohn's disease, thecolonic epithelium showed comparable levels ofimmunoreactivity and mRNA expression to those ofcontrol, except for the decreased immunoreactivity insevere inflamed lesions with deep ulcer. In contrary, alack or decrease of immunoreactivity was relevant inulcerative colitis regardless of the histological degree of inflammation. The mRNA expression wasalso significantly decreased in ulcerative colitis. Thisstudy demonstrates that abnormality of epithelial cellsin ulcerative colitis includes the enzyme that regulates water and sodium absorption,which are physiologically essential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026699324927
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    Paper (German National Licenses)
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