ISSN:
1365-2133
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Summary Forty-five patients with cutaneous T-cell lymphomas (CTCL), 32 with mycosis fungoides (MF) and 13 with Sézary syndrome (SS), were treated with interferon-α2a (IFN-α2a) (6–9 ± 10IU daily) for 3 months. Those responding to treatment were then treated with interferon-α alone (6–9 ± 106 IU three times weekly), and non-responders received a combination of etretinate(0·5 mg/kg/day) and IFN-α2a in similar concentrations. After 12 months of treatment, 28/ 45 patients (62–2%) were in complete or partial (〉50%) remission. Of these. 17 (60±7%) were receiving IFN-α alone and II the combined interferon–retinoid therapy. Of the patients with MF stage I and II,20/25 were responders (12 receiving IFN-α alone and eight on combined therapy), whereas only 8/20 with Stage IV or SS responded to treatment (five receiving IFN-α2a alone and three combined therapy). These results suggest that the association of etretinate with low-dose recombinant IFN-α2a is an effective means of treating epidermotropic CTCL, particularly in the early stages.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2133.1991.tb14772.x
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