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  • 1
    ISSN: 1432-1440
    Keywords: Human immunodeficiency virus ; Acquired immunodeficiency syndrome ; Hemophiliacs ; Natural history ; Virus isolation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary At our institution 686 hemophiliacs are being treated. Of them 402 (59%) are anti-HIV-seropositive. The general use of heat-treated clotting factor products was begun in July 1983, and from May 1984 all patients exclusively used heat-treated clotting factors. Thus, one can assume that infection occurred no later than early 1984 in our patients. Since December 1985 HIV-positive hemophiliacs have regularly been clinically and immunologically examined. Most of the 306 patients who could be investigated were clinically symptom-free at the time of their first visit. However, 45 patients have developed AIDS from 1982 through August 1988. The mean survival time of hemophiliacs with AIDS is less than 6 months. In 36% of those 274 patients who have been followed for a mean period of 14 months the clinical stage of the disease worsened by at least one stage according to the classification system proposed by the Centers for Disease Control. We did not find a correlation between clotting-factor consumption during the years 1984–1986 and the actual clinical stage of the patients. Virus isolation from peripheral blood lymphocytes (PBIs) answered the question whether anti-HIV seropositive hemophiliacs are not only immunized but really infected in many more cases than those revealed by detection of p24 antigen or decline of p24 antibody. Positive viral culture correlated strongly with a drop in CD4+ lymphocytes under the level of 400/µl. However, HIV could not be cultured regularly in advanced cases, suggesting that virus replication in PBLs is not necessarely the cause of depletion of T-helper cells. There is no evidence that the natural history of HIV infection in hemophiliacs is different from that in other HIV-infected patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Rheumatologie 58 (1999), S. 213-217 
    ISSN: 0340-1855
    Keywords: Key words Pyogenic sacroiliitis ; unilateral posttraumatic sacroiliac joint ankylosis ; HLA-B27 ; conventional radiograph ; computed tomography ; Schlüsselwörter Pyogene Sakroiliitis ; unilaterale posttraumatische Ankylose des Sakroiliakalgelenkes ; HLA-B27 ; konventionelle Röntgendiagnostik ; Computertomographie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir beschreiben eine HLA-B27 positive Patientin mit einer posttraumatischen pyogenen Sakroiliitis, die zu einer kompletten unilateralen Ankylose führte ohne Zeichen für eine HLA-B27 assoziierte Spondyloarthropathie. Die Sakroiliitis ist gewöhnlich eines der frühzeitigen Manifestationen der ankylosierenden Spondylitis. Die asymmetrische Sakroiliitis ist besonders häufig bei anderen entzündlichen Erkrankungen wie zum Beispiel der reaktiven Arthritis, dem Reiter Syndrom, der Spondylitis assoziiert mit einer Psoriasis oder anderen chronisch entzündlichen Darmerkrankungen. Viele, aber nicht alle dieser Erkrankungen, zeigen eine erhöhte Prävalenz bei HLA-B27 positiven Individuen. Anhand dieses Fallberichts wird die Differentialdiagnose der unilateralen Sakroiliitis diskutiert.
    Notes: Summary We describe an HLA-B27 positive patient in whom posttraumatic pyogenic sacroilitis led to complete unilateral sacroiliac joint ankylosis in the absence of any signs indicative of HLA-B27 associated spondyloarthropathy. Sacroiliitis is the pathologic hallmark – and usually one of the earliest pathologic manifestations – of ankylosing spondylitis (AS). Bilateral sacroiliitis is typical for ankylosing spondylitis. The frequency of asymmetric sacroiliitis may be higher in other inflammatory disorders, e.g., reactive arthritis, Reiters syndrome, spondylitis associated with psoriasis, or infammatory bowel disease. Most but not all of these disorders show an increased prevalence among individuals who have inherited the HLA-B27 gene. In the context of this case, we discuss the differential diagnosis of unilateral sacroiliitis.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 13 (1995), S. 229-250 
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Cytokine 6 (1994), S. 568 
    ISSN: 1043-4666
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 333 (1988), S. 402-402 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-Ekert's assertion1, which has led to discussion23, that haemophiliacs infected with human immunodeficiency virus (HIV) may carry a tenfold-lower risk of developing AIDS than HIV-infected individuals from other risk groups, is at odds with our own findings. As we reported at the recent European ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 68 (1990), S. 1203-1207 
    ISSN: 1432-1440
    Keywords: Hemophilia ; Human immunodeficiency virus ; Heterosexual transmission ; CD4+ cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Of 686 hemophiliacs who are being treated at our institution, 402 (59%) are HIV-seropositive. Onehundredseventy-eight heterosexual partners of HIV-infected hemophiliacs have been serologically examined; 19 (11%) are HIV-positive. So far none of the seropositive partners suffers from ARC or AIDS. The rate of heterosexual transmission of HIV is statistically significantly correlated with the CD4+ count of the HIV-infected index patient. No such correlation was found with the index patient's clinical stage or the isolation of HIV from the index patient's blood. Of 39 seronegative female partners who were investigated clinically and immunologically, 17 showed pathologically increased numbers of CD8+ counts. In one case, HIV was transmitted from a female patient with von Willebrand's disease to her husband. As compared to other groups at risk for AIDS, the rate of heterosexual HIV transmission is comparatively low in hemophiliacs. The exact reason for this difference is not yet known. The relevance of the immunopathological findings in seronegative sexual partners of hemophiliacs also remains to be determined.
    Type of Medium: Electronic Resource
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