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  • 1
    Electronic Resource
    Electronic Resource
    Role of active oxygen species in diethyldithiocarbamate-induced gastric ulcer in the rat (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 281-283 
    Details
    ISSN: 1420-9071
    Keywords: Diethyldithiocarbamate ; gastric ulcer ; superoxide dismutase ; catalase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Diethyldithiocarbamate, an inhibitor of Cu,Zn-superoxide dismutase, was recently found to be ulcerogenic in the rat stomach, and active oxygen species were found to be responsible for its ulcerogenicity. To clarify which active oxygen species play a role in ulcerogenesis, the effects of various scavengers and iron-chelators were studied. As superoxide dismutase and catalase reduced the ulcerogenesis induced by diethyldithiocarbamate, the superoxide radical and hydrogen peroxide were considered to play a pathogenic role in this ulcer model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951766
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  • 2
    Electronic Resource
    Electronic Resource
    A crossreactivity at the immunoglobulin E level of the cell wall mannoproteins of Candida albicans with other pathogenic Candida and airborne yeast species (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 27 (1997), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Candida albicans crossreacts with Saccharomyces cerevisiae or Pityrosporum ovate at the IgE level. However, the extent of crossreactivity of C. alhicans with other yeast species is not known.Objective The crossreactivity at the immunoglobulin E (IgE) level of Candida alhicans with other pathogenic Candida species and to the airborne yeast species Cryptococcus and Rhodotorula was studied by immunoblot analysis.Methods Crude antigens, designated as heat extract, were prepared from 13 different yeast species and a dot blot test was performed to detect IgE antibodies against each of the heat extracts in 349 patients with allergies who were positive for IgE antibodies against C alhicans in a CAP system.Results In the dot blot test, most of the sera reacted with the heat extracts of not only C. albicans but also those prepared from the other yeast species. The sera of 41 of the 349 patients (11.7%) reacted with the heat extracts of all 13 yeast species. The extent of the binding of IgE antibodies to multiple yeast species correlated with both the fluorescence intensities measured in the CAP system and the intensities of dots generated by the heat extract of C. alhicans in the dot blot test. In an inhibition dot blot test, mannoproteins. but not proteins, of C. albicans strongly inhibited the subsequent binding of IgE antibodies to all yeast species.Conclusion Our data suggest that the C. albicans mannoproteins are responsible for the crossreactivity among these yeast species at the IgE level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.1997.1620970.x
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  • 3
    Electronic Resource
    Electronic Resource
    Detection of IgE antibody against Candida albicans enolase and its crossreactivity to Saccharomyces cerevisiae enolase (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 25 (1995), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Candida albicans 46 kDa protein, a glycolytic enolase enzyme, is an important allergen of the yeast. The purpose of the study was to detect circulating IgE and IgG antibodies against C. albicans enolase (CAE). We isolated CAE using sequential DEAE Sephacel and Pl 1 column chromatography from spheroptasts of C. albicans, and delected IgE and IgG antibody against CAE by immunoblotting. Crossreactivity of enolose of C. albicans and Saccharomyces cerevisiae was also examined by immunoblotting and immunoblot inhibition test. Among 54 sera with positive IgE RAST to C. albicans, IgE antibody against CAE was detected in 20 sera (37%) and IgG antibody in 27 sera (50%). The allergenic potency of CAE was confirmed using a skin-prick test in three patients. Simultaneous IgE binding to S. cerevisiae enolase was only observed in four out of 20 sera reacting to CAE. Pre-treatment of sera with CAE completely inhibited IgE binding to S. cerevisiae enolase. Whereas the latter only partially inhibited IgE binding to CAE. These results suggest that CAE shares some crossreacting epitopes with S. cerevisiae enolase, representing minor components of CAE but dominant segments of S. cerevisiae enolase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1995.tb01089.x
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of IgE-binding epitopes on Candida albicans enolase (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 25 (1995), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Candida albicans enolase is one of the important allergens in Candida allergy. We isolated and purified 46 kDa C. albicans enolase (CAE) from C. albicans and characterized epitopes for IgE antibody by lectin-blotting and enzymatic digestion followed by sodium dodecyl sulfale polyacrylamide gel electrophoresis (SDS-PAGE) and immunobiotting. Lectin blotting and deglycozilation indicated that this protein did not contain polysaccharide side chains. The purified CAE and recombinant fusion protein produced from CAE gene possessed common epitopes for IgE antibody. We estimated IgE binding epitopes on the basis of reported amino acid sequences from the analysis of cDNA encoding CAE. V8 protease digestion of CAE gave six polypeptide fragments (A-F). The N-termini of each fragment were confirmed by amino acid sequence and the C-termini were estimated by molecular weights of each fragment and the specific cutting site of V8 protease. Fragment C (25.0 kDa; F-171-I-399) reacted to 90% IgE antibodies examined, whereas fragments D (21.0 kDa; F-171-1-360), E (16.2kDa: F-171-D-317) and F (13.0kDa; A-47-E-170) showed no IgE binding. Our results suggest that epitopes for IgE antibodies exist near the C-terminal of the protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1995.tb01090.x
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  • 5
    Electronic Resource
    Electronic Resource
    Serum levels of soluble stem cell factor and soluble KIT are elevated in patients with atopic dermatitis and correlate with the disease severity (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Mast cell infiltration in skin lesions of atopic dermatitis (AD) is considered to play an important role in the pathogenesis of the disease. The most common factor that stimulates mast cell growth, migration and differentiation is stem cell factor (SCF), and the interaction of SCF and its receptor, KIT (tyrosine kinase transmembrane receptor), appears to be the key event in the recruitment and proliferation of mast cells. Objectives To determine whether any altered metabolism of SCF and/or KIT is present in patients with AD. Methods We measured serum levels of soluble SCF (sSCF) and soluble KIT (sKIT) using enzyme-linked immunosorbent assay in 54 patients with AD, five patients with erythrodermic psoriasis vulgaris and 64 healthy individuals. Results Serum levels of both peptides in AD patients were significantly higher than those in healthy individuals, whereas patients with psoriasis vulgaris did not show any difference from healthy controls. Both sSCF and sKIT levels were positively correlated with the disease severity in AD patients, and decreased after effective treatment with topical corticosteroids. Conclusion Serum levels of sSCF and sKIT may be useful indicators for evaluation of the activity and severity of AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04224.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of CoCrZr seed layer on noise properties and microstructure of CoCrPt media (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 85 (1999), S. 4717-4719 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have developed a nonmagnetic (CoCr30)Zrx [x=7, 10, 14 at. %] seed layer for CoCrPt glass media and have compared its structural and noise properties to those of the media with a Ta/Zr dual seed layer, which have lower media noise than the media with a Cr seed layer. The media with a (CoCr30)Zr10 seed layer had lower media noise than that with the Ta/Zr dual seed layer, which is attributed to reduced grain size in the magnetic layer. However, the media noise increased drastically owing to a 78% increase of the grain size in the magnetic layer when the Zr content in the seed layer increased from 10 to 14 at. %. The transmission electron microscope analysis indicates that the (CoCr30)Zr10 seed layer has a nanocrystalline structure, while (CoCr30)Zr14 was almost amorphous. This would be the main reason of the drastic change in the grain size of the magnetic layer. The microstructure of the CoCrZr seed layer is very sensitive to the Zr content and strongly affects the microstructure of the magnetic layer and thereby media noise. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.370458
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of an intermediate layer on the magnetic and recording characteristics of CoCrPtTa media (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 6857-6859 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Effects of bcc and hcp intermediate layers between a bcc–Cr80Ti20 underlayer and a hcp–CoCrPtTa magnetic layer on magnetic and recording characteristics were investigated. The medium without an intermediate layer has a low coercivity Hc of 0.27 kOe due to the perpendicular orientation of the c axis of the CoCrPtTa layer. By introducing a 5-nm-thick intermediate layer of bcc–Cr60Mo40 or hcp–Co70Cr30, the c axis of the CoCrPtTa layer can be effectively in-plane oriented, resulting in a high Hc of 2.71–2.87 kOe and a coercive squareness S* of 0.72–0.81. The medium with the Cr60Mo40 layer has lower media noise than the medium with the Co70Cr30 layer. This lower noise is considered to be caused by the small grain size of 10.4 nm. The addition of the thin Cr60Mo40 intermediate layer is therefore effective to obtain both high Hc and low noise in the CoCrPtTa media with the CrTi underlayer. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372865
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  • 8
    Electronic Resource
    Electronic Resource
    Magnetoresistance and structure of Fe/Cu multilayers
    Amsterdam : Elsevier
    Journal of Magnetism and Magnetic Materials 126 (1993), S. 443-444 
    Details
    ISSN: 0304-8853
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-8853(93)90650-Q
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of cytochalasin A on actin distribution in the fission yeastSchizosaccharomyces pombe studied by fluorescent and electron microscopy (1993)
    Springer
    Protoplasma 176 (1993), S. 24-32 
    Details
    ISSN: 1615-6102
    Keywords: Actin ; Cytoskeleton ; Schizosaccharomyces pombe ; Freeze substitution ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Actin distribution and ultrastructure of the fission yeastSchizosaccharomyces pombe treated with cytochalasin A (CA) were investigated by fluorescence microscopy using rhodamine-conjugated phalloidin (rh-ph) and freeze substitution electron microscopy. Among the cytochalasins tested, CA was most effective and at 5 μg/ ml inhibited the appearance of the actin ring at the cell equator at the stage prior to septum formation and the accumulation of actin dots at the septum-forming site both in wild-type cells and the mutantcdc 11, which is defective in septum formation at restrictive temperature. Freeze substitution electron microscopy of CA-treated cells revealed the displacement and morphological alteration of cytoplasmic vesicles and dictyosomes within 30 min and the appearance of dense bodies in the cytoplasm. A sub-population of cytoplasmic vesicles and dictyosomes were insensitive to CA and maintained their original structure. An electron less dense layer containing filamentous material was noted beneath the plasma membrane and thought to be the area of heavy actin patches stained with rh-ph at the cells ends. These results suggest that CA disrupted an actin network that normally maintains the organization of the secretory pathway involving dictyosomes and vesicles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01378936
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  • 10
    Electronic Resource
    Electronic Resource
    A ring structure around the dividing plane of theCyanidium caldarium chloroplast (1986)
    Springer
    Protoplasma 130 (1986), S. 211-213 
    Details
    ISSN: 1615-6102
    Keywords: Chloroplast division ; Cyanidium caldarium ; Hot-spring alga ; Phycobilisome ; Plastid-dividing ring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276603
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