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  • 1
    Electronic Resource
    Electronic Resource
    Examination of islets in the pancreas biopsy specimens from newly diagnosed Type 1 (insulin-dependent) diabetic patients (1990)
    Springer
    Diabetologia 33 (1990), S. 105-111 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes mellitus ; pathology ; pathogenesis ; diagnosis ; pancreas biopsy ; laparoscopy ; immunohistochemistry ; MHC class I antigen ; MHC class II antigen ; immunotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We attempted to examine the immunopathological change of the pancreatic islets of newly diagnosed Type 1 (insulin-dependent) diabetic patients and thereby to obtain useful information for the therapy of the patients. For this purpose, pancreas biopsy under laparoscopy was performed 2–4 months after the onset of Type 1 diabetes in seven newly diagnosed patients. All biopsies were performed safely without any complications. Immunohistochemical examination of the biopsy specimens revealed a marked decrease of insulin-containing cells, preservation of glucagon-containing cells, and various degrees of expression of MHC class I and class II antigens in islet cells and in endothelial cells within and around the islets. Signs of active autoimmune phenomena, e. g. lymphocytic infiltration or immunoglobulin deposition in islets, were not detected in any of these patients by light microscopical evaluation. We conclude that pancreas biopsy under laparoscopy has shown various immunological changes in the islets of newly diagnosed Type 1 diabetic patients. Pancreas biopsy, however, may not be suitable under the present protocol for the selection of patients for immunotherapy because of problems including sampling errors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401048
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  • 2
    Electronic Resource
    Electronic Resource
    Purification and Characterization of Salicylhydroxamic Acid Reductase from Rat Liver
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 302 (1993), S. 356-361 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/abbi.1993.1223
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Biochemical studies of glycosaminoglycans in nanophthalmic sclera (1995)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 233 (1995), S. 58-62 
    Details
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract • Background: Since Brockhurst reported the connection between uveal effusion in nanophthalmic eyes and their scleral alterations and treated them with vortex vein decompression or sclerectomy, many observers have found abnormal accumulation of glycosaminoglycans (GAGS) in nanophthalmic sclera. These GAG abnormalities were thought to effect the collagen changes, though it was not clear which GAGs were changed. • Methods: GAGs were isolated and their contents were determined in scleral specimens from three nanophthalmic patients and five age-matched controls, using electrophoresis and the cetylpyridinium method. • Results: Hyaluronic acid, dermatan sulfate and chondroitin sulfate were the major GAGs in both nanophthalmic and control samples. Nanophthalmic sclera showed 2.4-fold, 10-fold and 5.5-fold increases in hyaluronic acid, dermatan sulfate and chondroitin sulfate, respectively, compared with the controls. • Conclusion: The results suggest that increased levels of GAGS, particularly of dermatan sulfate and chondroitin sulfate may contribute to the abnormalities of collagen fibrillogenesis and be closely involved with the pathogenesis of nanophthalmos.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00241472
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  • 4
    Electronic Resource
    Electronic Resource
    Preventive effect of a new immunosuppressant FK-506 on insulitis and diabetes in non-obese diabetic mice (1990)
    Springer
    Diabetologia 33 (1990), S. 503-505 
    Details
    ISSN: 1432-0428
    Keywords: Non-obese diabetic (NOD) mouse ; FK-506 ; insulitis ; Type 1 (insulin-dependent) diabetes mellitus ; immunotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the effect of an immunosuppressant FK-506 on histological change of islets, the onset of diabetes, and the change of spleen cell subsets in female non-obese diabetic mice. Mice administered intraperitoneally with FK-506 from 5 to 20 weeks of age showed marked suppression of mononuclear cell infiltration (insulitis) at 10 weeks of age. Among the subsets of the spleen cells, a significant decrease in the population of Thyl.2-positive T cells (pan-T), L3T4-positive T cells (mainly helper/inducer), and Lyt2-positive T cells (mainly suppressor/cytotoxic) was observed in FK-506-treated mice. Furthermore, glucose tolerance of the mice at 15 weeks of age was clearly improved. Cumulative incidence observed up to 40 weeks of age was 86% in control mice and 23% in FK-506-treated mice (p〈0.01). These data indicate that FK-506 has a preventive effect on insulitis and diabetes by the suppression of cell-mediated autoimmunity in non-obese diabetic mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405113
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  • 5
    Electronic Resource
    Electronic Resource
    Dynamic stress intensity factor of a cracked dielectric medium in a uniform electric field (1996)
    Springer
    Acta mechanica 117 (1996), S. 1-10 
    Details
    ISSN: 1619-6937
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary We consider the scattering of normally incident longitudinal waves by a finite crack in an infinite isotropic dielectric body under a uniform electric field. By the use of Fourier transforms, we reduce the problem to that of solving two simultaneous dual integral equations. The solution of the dual integral equations is then expressed in terms of a Fredholm integral equation of the second kind having the kernel that is a finite integral. The dynamic stress intensity factor versus frequency is computed, and the influence of the electric field on the normalized values is displayed graphically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01181032
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    Paper (German National Licenses)
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