ISSN:
1420-9071
Keywords:
Stearoyl CoA desaturase
;
streptozocin
;
streptozocin antagonist
;
insulin effect on desaturase
;
thyroid hormone effect on desaturase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Stearoyl CoA desaturase activity in liver microsomes, and insulin, thyroxine, and triiodothyronine levels in serum were measured after administration of streptozocin (STZ) and its antagonists to rats. The effect of STZ, which caused hyperglycemia and inhibited the desaturase activity, was antagonized by 2-desoxyglucose and 3-O-methyl-glucose; 1-O-methyl-3-desoxyglucose and 1-O-methyl-3-O-methylglucose were without any effect. The enzyme activity plotted against insulin levels showed a broad sigmoidal curve, whereas the activities versus thyroid hormone levels showed steeper sigmoidal curves.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01959152
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