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  • 1
    Electronic Resource
    Electronic Resource
    Reliability of current techniques for histamine determination in human plasma: The european external quality control study 1988 (1990)
    Springer
    Inflammation research 30 (1990), S. 274-277 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The increasing importance of measuring histamine in many clinical conditions and the variety of currently used techniques enforced us to organize an external quality control study (ring study) on the reliability of histamine measurements in European laboratories. Three plasma quality control samples in duplicate (lyophilized) with different amounts of histamine (0–5 ng/ml), two different aqueous histamine standard samples and one solvent sample were sent to 10 laboratories for analysis of their histamine content. The following methods were used: gas chromatographic-massespectrometric technique (n=2), single isotope assay (n=1), fluorometric-fluoroenzymatic assay (n=3), radioimmunoassay (n=3), HPLC technique (n=2). The study was performed and evaluated according to the approved recommendation (1983) of the International Federation of Clinical Chemistry (IFCC). This first report of the study is concentrated on the imprecision and inaccuracy of the different principal methods and laboratories by comparing two unrelated plasma histamine samples of different analyte concentrations (target values and SD: 4.39±0.51 ng/ml and 0.99±0.17 ng/ml). This study showed a fairly good agreement between most participants. 7/11 results obtained with 4 different methods were accurate and precise in the plasma range of histamine (Youden plot). Results outside the borderlines turned out to be a problem of the analyst rather than the method itself. It is suggested to define reference values for plasma histamine and to establish reference laboratories and methods according to the IFCC-guidelines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01969059
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of decontamination of the digestive tract on the urinary excretion of histamine and some of its metabolites (1984)
    Springer
    Inflammation research 15 (1984), S. 238-241 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Urinary excretions of histamine, Nt-methylhistamine and Nt-methylimidazoleacetic acid have been determined for 8 healthy volunteers during 14 consecutive days. Selective decontamination of the digestive tract was performed from day 3 to day 6, followed by total decontamination from day 7 to day 10. Urinary excretions of Nt-methylhistamine and Nt-methylimidazoleacetic acid decreased to a small though significant degree (about 15–20%) after total decontamination, suggesting a histamine production by anaerobic bacteria. Cadaverine decreased for about 70% under both selective and total decontamination, suggesting that this amine in human urine mainly originates from aerobic bacteria in the intestinal tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972355
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  • 3
    Electronic Resource
    Electronic Resource
    Histamine in late asthmatic reactions following house-dust mite inhalation (1985)
    Springer
    Inflammation research 16 (1985), S. 252-255 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate the role of histamine in the late asthmatic reaction (LAR) following house-dust mite (HDM) inhalation, we studied, with hourly intervals, urinaryN τ-methylhistamine (an important metabolite of histamine) in 14 allergic asthmatic patients before and after broncho provocation with HDM. Four patients showed an early asthmatic reaction (EAR), while 10 patients developed a LAR as well. In the hour following the EAR a significant increase in urinaryN τ-methylhistamine was observed as compared to the control day (0.01〈p〈0.05). During the LAR no increase of this metabolite was detected in the urine of the patients. Additionally, histamine was measured in broncho alveolar lavage fluid (BAF) obtained from 6 patients during the HDM-provoked LAR and compared to histamine levels in BAF from patients without a LAR, following broncho provocation. In the LAR group higher histamine levels were found than in the other patient and control groups. For the whole patient group no correlation was found between the degree of bronchial obstruction during the LAR and the BAF histamine values. No difference was found inN τ-methylhistamine in BAF between patients with LAR and controls. Thus histamine metabolite studies in the urine failed to provide evidence of involvement of histamine in the LAR, while further data are needed to interpret the results of local sampling in the lung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983153
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of oral slow-release terbutaline on early morning dyspnoea (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 159-162 
    Details
    ISSN: 1432-1041
    Keywords: terbutaline ; asthma ; slow-release formulation ; early morning dyspnoea ; side-effects ; serum terbutaline level
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eight male patients with partly reversible airflow obstruction, who had a diurnal variation in peak expiratory flow rate (PEFR) of more than 20% were treated with placebo and slow-release terbutaline tablets (5 mg at 08.00 hours and 10 mg at 20.00 hours) for 8 days. On Day 8 of each period, PEFR and serum terbutaline were measured at 4 and 2-h intervals, respectively. PEFR on the terbutaline day showed a significant increase at 08.00, 12.00, 24.00, 04.00 and 08.00 hours as compared to the placebo day. Slow-release terbutaline prevented early morning dyspnoea. The serum concentration was 3.3 ng/ml during the day and 3.5 ng/ml during the night. During terbutaline therapy the patients reported fewer complaints than during the placebo period. It was concluded that slow-release terbutaline tablets are suitable for twice daily treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609685
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  • 5
    Electronic Resource
    Electronic Resource
    Determination of histamine in human plasma: the European external quality control study 1988 (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 20 (1990), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: There is an increasing interest in measuring human plasma histamine levels in various clinical conditions. A variety of ‘old’ and newly developed techniques are applied to meet this demand. However, the discrepancy between reported reference values for histamine in human plasma measured using this variety of techniques, suggests the existence of a certain degree of inaccuracy and imprecision. We therefore organized an external quality control study on the reliability of current histamine determinations in European laboratories. Three lyophilized plasma quality control samples, in duplicate, covering the normal and pathological range of histamine concentrations (0–45 nmol/l), two different aqueous histamine standard samples and one solvent sample were sent to 10 laboratories for the analysis of their histamine content. The following methods were used: gas chromatography-mass spectrometry (n= 2), enzymatic single isotopic assay (n= 1), fluorometric-fluoroenzymatic assay (n= 3), radioimmunoassay (n= 3) and high performance liquid chromatography (n= 2). The study was performed and evaluated according to the approved recommendations (1983) of the International Federation of Clinical Chemistry (IFCC). The target values ±s.d. of the three plasma samples were: 39·5±4·6 nmol/1 (CV=ll·6%), 2·3 ± 2·2 nmol/1 (CV = 96%) and 8·9±1·5 nmol/1 (CV = 17%), respectively. The target values ±s.d. of the two aqueous samples were: 0·9±1·1 nmol/1 (CV = 120%; true value: 0·00 nmol/1) and 10·2 ± 0·5 nmol/1 (CV = 5·3%; true value: 10·0 nmol/1), respectively. A Youden plot of two unrelated plasma samples in the pathological range defined 7/11 results as accurate and precise. The Youden plot of the two unrelated aqueous samples only denned 6/11 results as accurate and precise. In general, estimating histamine concentrations within the normal range seemed to be the most difficult part of measuring histamine in human plasma samples. It is suggested to define reference standards, methods and laboratories for plasma histamine determinations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1990.tb02793.x
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  • 6
    Electronic Resource
    Electronic Resource
    Measurement of urinary Nτ-methylhistamine excretion: Correlation of a newly developed radioimmunoassay (RIA) with gas chromatography mass spectrometry (GCMS) (1991)
    Springer
    Inflammation research 33 (1991), S. 215-217 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A newly developed radioimmunoassay (RIA, Y) for the determination of urinary Nτ-methylhistamine concentrations was correlated with gas chromatography mass spectrometry (GCMS, X). In 34 urine samples, with histamine and Nτ-methylhistamine levels within our reference values, the correlation was: Y=1.47X−0.245 μmol/l (r=0.92;p-slope ≤0.0001). In 14 pathological urine samples, derived from patients with mastocytosis and having upper reference values, the correlation was: Y=1.75X−1.02 μmol/l (r=0.93;p-slope ≤0.001). In spite of the greater specificity of the monoclonal antibody for Nτ-methylhistamine compared with that of histamine, relatively high urinary histamine concentrations gave a false positive influence on the RIA results, which was 100% when the histamine/Nτ-methylhistamine ratio was about 19. Clear cases of mastocytosis can be diagnosed, using the RIA-kit, but for a more precise Nτ-methylhistamine value GCMS analyses will remain necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01993171
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  • 7
    Electronic Resource
    Electronic Resource
    Correlation between urinary levels of histamine metabolites in 24-hour urine and morning urine samples of man: Influence of histamine-rich food (1989)
    Springer
    Inflammation research 27 (1989), S. 205-207 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study, we have determined and correlated the excretion of the 2 most important histamine metabolites, Nτ-methylhistamine and Nτ-methylimidazoleacetic acid, in 24-hour urine and morning urine samples of 14 normal healthy persons. We found no significant difference between morning urine and 24-hour urine samples, provided that the subjects were on a histamine-poor diet for at least 24 hours. We also studied the influence of the consumption of histamine-rich foodstuffs on the reliability of these parameters. The morning urinary Nτ-methylhistamine excretion is less affected by histamine-rich foodstuffs and therefore proposed to be the most reliable parameter for endogeneous histamine release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02222240
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  • 8
    Electronic Resource
    Electronic Resource
    The Prevalence of Low Bone Mineral Density in Dutch Perimenopausal Women: The Eindhoven Perimenopausal Osteoporosis Study (1998)
    Springer
    Osteoporosis international 8 (1998), S. 404-409 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Bone mineral density – Estrogens – Hysterectomy – Menopause – Osteopenia – Osteoporosis –
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The aim of this study was to estimate the prevalence of osteopenia and osteoporosis in perimenopausal women, and to assess determinants of low bone mineral density (BMD). All women born between 1941 and 1947 (aged between 46 and 54 years) living in the city of Eindhoven were invited to participate in the study; 5896 white Dutch women, representing 73% of the total number of Dutch women in this age group, were studied. Of these, 24% were using estrogen preparations and 19% had undergone hysterectomy, with or without oophorectomy. All women were interviewed and bone mineral density (BMD) of the lumbar spine was measured by dual-energy X-ray absorptiometry (DXA). Osteopenia and osteoporosis were defined according to the criteria proposed by a WHO working group. In the population studied the prevalence of osteopenia and osteoporosis was 27.3% and 4.1%, respectively. With progression from premenopause to menopause, the prevalence of osteoporosis increased from 0.4% to 12.7%, and that of osteopenia from 14.5% to 42.8%. An increased risk for low BMD (osteopenia and osteoporosis) was associated with age, menopausal status and smoking, while alcohol consumption, high body mass index (BMI) and use of estrogens had a protective effect. This study of a large population-based cohort of perimenopausal women revealed a high prevalence of low bone mass and, therefore, a higher risk for osteoporotic fractures. The data further suggest that, when issues on the long-term efficacy and safety of preventive treatments are resolved, it may be possible to identify women at higher risk who are most likely to benefit from screening strategies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050083
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  • 9
    Electronic Resource
    Electronic Resource
    Urinary excretion of histamine and some of its metabolites in man: Influence of the diet (1984)
    Springer
    Inflammation research 15 (1984), S. 189-194 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Urinary excretions of histamine,N τ-methylhistamine andN τ-methylimidazoleacetic acid have been determined in 10 normal subjects on 3 different diets, containing a very low protein, a low protein and a high protein amount. Foodstuffs which could contain histamine were excluded. The mean excretion ofN τ-methylhistamine on the second day of each diet amounted to 0.861 μmol/24 h, 1.051 μmol/24 h and 1.378 μmol/24 h, respectively. The excretions of histamine andN τ-methylimidazoleacetic acid were not affected. In 6 normal persons on a protein low diet, the excretions of histamine,N τ-methylhistamine andN τ-methylimidazoleacetic acid have been determined for 10 days. On the fifth day, to 3 persons 200 μmol of histamine was given orally, the other 3 persons received a high protein diet. The persons receiving histamine showed a strongly enhanced excretion ofN τ-methylimidazoleacetic acid, corresponding to 36.1% of the administered histamine, whereas the urinary excretions of histamine andN τ-methylhistamine were only slightly elevated. On the high protein diet, only the excretion ofN τ-methylhistamine was slightly elevated. The urinary excretions of histamine in the female subjects sometimes showed unexpectedly high values. Most probably, this phenomenon is attributable to bacterial histamine production in the urogenital tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972348
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  • 10
    Electronic Resource
    Electronic Resource
    Measurement ofN τ-methylhistamine concentrations in plasma and urine as a parameter for histamine release during anaphylactoid reactions (1985)
    Springer
    Inflammation research 16 (1985), S. 76-79 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract N τ-methylhistamine concentrations in plasma and urine were determined using a newly developed simultaneous determination for histamine andN τ-methylhistamine, based on isotope dilution mass fragmentography. Three groups of patients were investigated: patients receiving intravenously-administered iodamide for excretory urography, patients receiving a wasp-sting challenge, and patients treated with an intravenously-administered muscle relaxant. In all patients showing a distinct systemic anaphylactic or anaphylactoid reaction histamine andN τ-methylhistamine concentrations were found to be elevated. From the results of this study it can be concluded thatN τ-methylhistamine in plasma and urine is a good parameter for histamine release, and that the determination of this histamine metabolite are less hampered by possible artefacts (due to basophil disrupture, a very short half-life time or bacterial production) than determinations of histamine itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983105
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