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  • 1
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Background  In spite of a perception that alcohol use is rampant in Nepal, there has been no survey to assess the extent of alcohol dependence in the country.Aims  (i) To assess prevalence of alcohol dependence in the community of Dharan and (ii) to correlate this with various socio-demographic characteristics.Design  The CAGE questionnaire was administered to all adult individuals in houses selected randomly in the township of Dharan.Findings  Among 2344 adults assessed, the prevalence of alcohol dependence was found to be 25.8%. The prevalence of alcohol dependence increased with age to peak in the age group 45–54 years and was more than twice as common in men as in women. Also, alcohol dependence was more common among those with lower level of education, widowers and divorcees and those belonging to the Matwali community. The extent of dependence was influenced by socio-cultural sanctions.Conclusions  The prevalence of alcohol dependence is too high for comfort in Dharan, a town in eastern Nepal. There is an urgent need to formulate a policy for substance abuse in the country taking into account the findings of this study.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Carfax Publishing, part of the Taylor & Francis Group
    Addiction 95 (2000), S. 0 
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical Systematics and Ecology 17 (1989), S. 167-174 
    ISSN: 0305-1978
    Keywords: Ophioglossum ; amino acids ; chemosystematics ; elements ; numerical taxonomy ; phenetics
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Chemical Physics Letters 43 (1976), S. 557-561 
    ISSN: 0009-2614
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    BioMetals 6 (1993), S. 133-138 
    ISSN: 1572-8773
    Keywords: biochemical alterations ; cadmium ; dietary iron deficiency ; lead ; metallothionein ; metals ; nickel ; rat ; tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The influence of dietary iron deficiency on acute nickel, lead or cadmium toxicity as reflected by the induction of hepatic, renal and intestinal metallothionein (MT), disposition of the metals, and alterations in hematological parameters was investigated in rats. The administration of cadmium induced the hepatic, renal and intestinal MT while that of nickel or lead induced hepatic MT only. However, dietary iron deficiency did not influence the cadmium induced tissue MT but enhanced the ability of nickel or lead to restore the normal synthesis of renal and intestinal MT lowered under the influence of reduced body iron status. The accumulation of lead in liver and kidney and that of cadmium enhanced in liver only, while tissue deposition of nickel remained unaffected by iron deficiency. The induction of hepatic MT by three metals appears related to the concomitant rise in the hepatic zinc, calcium and iron levels in normal rats. However, dietary iron deficiency increased the hepatic zinc in response to nickel or cadmium and that of heptic calcium in response to lead.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-2568
    Keywords: gastroesophageal reflux ; asthma ; bronchodilators ; positions ; eating
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gastroesophageal reflux is common in asthmatics. To determine whether bronchodilators, the supine position, or eating affect gastroesophageal reflux, we performed ambulatory 24-hr pH monitoring on 44 controls and 104 unselected adult asthmatics. All asthmatics had discrete attacks of wheezing and documented reversible airway obstruction of at least 20%. The presence or absence of gastroesophageal reflux symptoms was not used as a criterion for patient selection. Chronic bronchodilator therapy was required by 71.2% of the asthmatics, and was continued during the test. Asthmatics had significantly worse GER than controls during the 3-hr postprandial period, which continued into the nonpostprandial period up to the next meal. Significant differences were present for esophageal mucosal acid contact time, frequency of reflux episodes, and clearance times. During the nonpostprandial periods asthmatics had four times the acid reflux as controls and 19-fold the frequency of prolonged reflux episodes. There were no differences between asthmatics on bronchodilators and those not on bronchodilators in any of the reflux parameters during the upright (postprandial, nonpostprandial) period or supine (sleep) period (P=NS). We conclude that: (1) regardless of the use of bronchodilator therapy, asthmatics have significant GER when asleep and after meals that continues beyond the postprandial period to the next meal; and (2) asthmatics receiving bronchodilators have similar gastroesophageal reflux patterns after eating, in the nonpostprandial period, and when asleep as asthmatics not receiving bronchodilators.
    Type of Medium: Electronic Resource
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