ISSN:
1420-9071
Keywords:
Vitamin B6
;
glycogen phosphorylase mRNA
;
rat liver and muscle
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The effect of vitamin B6 deficiency on the expression of glycogen phosphorylase mRNA in rat liver and skeletal muscle was investigated. The level of phosphorylase mRNA in the muscle of vitamin B6-deficient rats was reduced to 40% of that in the control rats. By contrast, the phosphorylase mRNA level was increased 5-fold in the liver of the deficient animals. It was also found that the expression of the β-actin gene, generally regarded as a ‘housekeeping’ gene, was unaffected by B6 deficiency in the muscle but was enhanced in the liver of the deficient animals. These observations suggest that vitamin B6 may modulate the transcriptional activation of the phosphorylase gene in a tissue-specific manner.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01984949
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