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  • 1
    Electronic Resource
    Electronic Resource
    Whole-body retention of mercury and selenium and histopathological and morphological studies of kidneys and liver of rats exposed repeatedly to mercuric chloride and sodium selenite (1978)
    Springer
    Archives of toxicology 40 (1978), S. 189-199 
    Details
    ISSN: 1432-0738
    Keywords: Mercury ; Selenium ; Retention ; Liver ; Kidney ; Ultrastructure ; Interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Distribution and retention of mercury and selenium was studied in rats exposed repeatedly to HgCl2 injections (0.5 mg Hg/kg to the tail vein every other day) and intragastrically to Na2SeO3 (0.5 mg Se/kg every day), applying combined and separate administration of these metals for 2 weeks. Whole-body retention of mercury in the presence of selenium was augmented by 20% and that of selenium in the presence of mercury by 4% with respect to the administered dose. Combined administration of mercuric chloride and sodium selenite brought about damage to the epithelial cells of renal proximal convolutions and formation of protein casts in their lumen. These changes had the same pattern as those induced by administration of mercuric chloride alone, but the intensity was lower. Submicroscopic studies revealed that repeated combined administration of sodium selenite and mercuric chloride did not completely abolish the mercury-induced mitochondrial swelling and contributed to chromatin destruction in the hepatocyte nuclei.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00364650
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  • 2
    Electronic Resource
    Electronic Resource
    Binding of mercury and selenium in subcellular fractions of rat liver and kidneys following separate and joint administration (1977)
    Springer
    Archives of toxicology 38 (1977), S. 217-228 
    Details
    ISSN: 1432-0738
    Keywords: Interaction ; Mercury ; Selenium ; Inorganic ; Subcellular distribution ; Mercury ; Selenium ; Biocomplexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Verteilung von Quecksilber und Selen wurde in zellfreien Fraktionen von Rattenleber und -nieren untersucht, nachdem getrennt oder zugleich HgCl2 bzw. Na2SeO3 zwei Wochen lang (0,5 mg Hg/kg jeden zweiten Tag i.V., 0,5 mg Se/kg jeden Tag per os, molares Verhältnis l ∶ 5) verabreicht worden waren. Das molare Verhältnis der Hgund Se-Konzentrationen schwankte in den zellfreien Fraktionen der untersuchten Organe beträchtlich. Selen verdrängte Quecksilber aus der löslichen Nierenfraktion. Quecksilber war hauptsächlich mit Metallothionein an die histonfreie Eiweißfraktion der Leberzellkerne gebunden. Unter dem Einfluß von Selen wurde die Hg-stimulierte Biosynthese von Metallothionein unterbunden.
    Notes: Abstract The distribution of mercury and selenium has been examined in subcellular fractions of rat liver and kidneys in prolonged exposure to HgCl2 and Na2SeO3 administered separately and simultaneously. The molar ratio of mercury and selenium concentrations in subcellular fractions of the organs examined varied considerably. Selenium displaced mercury from the soluble kidney fraction bound mainly with metallothionein to the nonhistone protein fraction of liver nuclei. The Hg-stimulated biosynthesis of metallothionein has been eliminated under the influence of selenium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293656
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of interaction between 65Zn, mercury and selenium in rats (retention, metallothionein, endogenous copper) (1983)
    Springer
    Archives of toxicology 53 (1983), S. 165-175 
    Details
    ISSN: 1432-0738
    Keywords: Interaction ; Zinc ; Mercury ; Selenium ; Inorganic ; Subcellular distribution ; Liver ; Kidney ; Metallothionein ; Endogenous copper
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Interaction of zinc with mercuric chloride and sodium selenite was studied in the rat at the organ and subcellular levels (liver and kidneys). Zinc chloride was administered subcutaneously at dose of 5 mg Zn/kg, mercury chloride into the tail vein at a dose of 0.5 mg Hg/kg (both metals every other day during 2 weeks) and sodium selenite intragastrically, at doses of 0.1 mg Se/kg, every day. Zinc retention in the rat did not exceed 20% and was unchanged in the presence of mercury. An interaction effect was reflected by an increased whole-body retention of zinc by selenium, mercury, and selenium. In the presence of selenium no peak of metallothionein-like proteins stimulated by zinc or mercury was found in the soluble fraction of the kidneys. The metallothionein level did not differ from that typical for control group animals, too. A significant increase in the level of endogenous copper was found only in the kidneys of rats exposed to zinc in the presence of mercury and selenium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302724
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of methylmercury on the distribution and excretion of selenium by the guinea pig (1983)
    Springer
    Archives of toxicology 54 (1983), S. 303-310 
    Details
    ISSN: 1432-0738
    Keywords: Guinea pig ; Selenium ; Methylmercury ; Distribution ; Excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of methylmercury (MeHg) on the tissue and subcellular binding of selenium was determined. Adult female guinea pigs received either75Se (as sodium selenite) or MeHg (as chloride) followed 5 h later by an equimolar dose of75Se. Animals were sacrificed 1,3,7, and 13 days after administration. Pretreatment with MeHg significantly altered the organ distribution of75Se, particularly during the first week of the study.75Se concentrations were markedly reduced in most organs of animals receiving both75Se and MeHg except the liver, which contained markedly elevated75Se levels. The subcellular distribution of75Se was also altered by MeHg. Within liver, kidney and brain,75Se was primarily bound to nuclear and mitochondrial fractions in both treatment groups, but nuclear binding was higher in animals receiving both compounds. Within nuclear fractions, most75Se was bound to insoluble-nonhistone proteins. In the presence of MeHg, total nuclear binding of75Se increased, but total binding to insoluble-non-histone proteins decreased. MeHg also reduced the total75Se binding to high molecular weight proteins of the soluble fraction. Alterations in tissue and subcellular binding of MeHg and Se may contribute to the lower degree of toxicity observed in animals receiving both compounds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01234483
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  • 5
    Electronic Resource
    Electronic Resource
    Binding of inorganic mercury by subcellular fractions and proteins of rat kidneys (1976)
    Springer
    Archives of toxicology 37 (1976), S. 57-66 
    Details
    ISSN: 1432-0738
    Keywords: Mercury, inorganic, subcellular distribution ; Mercury, inorganic, biocomplexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Anorganisches Quecksilber, Ratten in einer einzelnen Dose von 0,5 mg Hg/kg verabreicht, wurde in den Nieren vorwiegend in der löslichen (54%) und in der Kern-Fraktion (30%) angereichert, und in beiden Fraktionen wurde eine zeitabhängige Abnahme festgestellt. In der mitochondrialen und mikrosomalen Fraktion, in denen zuerst ca. 11 und 6% Quecksilber gefunden wurde, konnte über die erste Woche eine zunehmende Tendenz festgestellt werden. In der löslichen Fraktion waren die metallothionein-ähnlichen Eiweißstoffe von niedrigem Molekulargewicht vorwiegend für die Bindung von Quecksilber verantwortlich. In anderen Zell-Fraktionen war Quecksilber meistens an Eiweiß-stoffe von hohem Molekulargewicht gebunden.
    Notes: Abstract Inorganic mercury, administered to rats in a single dose of 0.5 mg Hg/kg is accumulated in the kidneys mainly in the soluble (54%) and nuclear (30%) fractions, showing decreasing tendency with time. Mitochondrial and microsomal fractions, initially accumulating approx. 11 and 6% of total Hg, show a tendency to increase the absolute level of Hg for the first week after administration. In the soluble fraction low-molecular weight, metallothioneinlike proteins are mainly responsible for the accumulation of mercury, in other fractions proteins of higher molecular weight prevail.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00353355
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