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  • 1
    Electronic Resource
    Electronic Resource
    Systemic adverse effects of topical treatment with brimonidine in an infant with secondary glaucoma (1999)
    Springer
    European journal of pediatrics 158 (1999), S. A685 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008324
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Natural rubber latex allergy: prevalence and risk factors in patients with spina bifida compared with atopic children and controls (1997)
    Springer
    European journal of pediatrics 157 (1997), S. 13-16 
    Details
    ISSN: 1432-1076
    Keywords: Key words Latex allergy ; Spina bifida ; Fruit allergy ; Atopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Type 1 allergy against natural rubber latex is an increasing problem in health care workers and children with spina bifida or urogenital malformations. The aim of our study was to evaluate the prevalence of latex IgE antibodies and cross-reacting fruit antibodies in patients with spina bifida compared with atopic and non-atopic controls. Risk factors for sensitization should be determined. Sera of 148 patients with spina bifida and 98 controls (44 with atopy) were screened for IgE antibodies against latex, banana and kiwi by fluorescence enzyme immunoassay (CAP system). Atopies, allergic symptoms after latex contacts and the number of operations were compiled by a questionnaire. Patients with spina bifida developed latex IgE antibodies (≥0.7 kU/l) more frequently (40.5%) than atopic children (11.4%) or healthy controls (1.9%). All 18 symptomatic patients belonged to the spina bifida group and had high values of latex antibodies. The risk for developing latex antibodies increases with the number of operations. There was no difference in the history of atopic diseases and in a screening test of IgE antibodies against inhalative allergens between latex sensitized and not sensitized children with spina bifida. Antibodies against banana were more frequent in the latex sensitized children with spina bifida. (18.3% vs 3.4%, P = 0.002). Conclusion The high prevalence of latex antibodies in children with spina bifida justifies a primary prophylaxis by avoiding latex contacts, especially during anaesthesia and surgery, a correlation between the number of operations and the development of latex antibodies exists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050758
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hypersensitivitätssyndrom durch Antikonvulsiva (1997)
    Springer
    Monatsschrift Kinderheilkunde 145 (1997), S. 109-113 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Carbamazepin ; Hypersensitivitätssyndrom ; Fieber ; Exanthem ; Lymphadenopathie ; Key words Carbamazepine ; Hypersensitivity syndrome ; Fever ; Skin rash ; Lymphadenopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 2 weeks after initiation of carbamazepine therapy a 3 year old boy presented with skin rash, fever, lymphadenopathy, hepatosplenomegaly and nephritis. After exclusion of infectious diseases our differential diagnosis focussed on carbamazepine induced hypersensitivity syndrome. We found a positive lymphocyte transformation assay and patch test to carbamazepine, indicating a specific response, but no anti-carbamazepine antibody, no circulating immune complexes and no decrease in complement components. The hypersensitivity syndrome refers to a severe hypersensitivity response due to a idiosyncratic reaction. The origin is unknown. The similarity to other multisystem disorders is discussed. Discussion: Not only aromatic antiepileptic agents (carbamazepine, phenobarbital, phenytoin) sulfonamides but as well allopurinol and gold salts are associated with the syndrome. Withdrawal of the drug and treatment with corticosteroids usually lead to complete recovery.
    Notes: Zusammenfassung Wir berichten über einen 3 jährigen Jungen, der 2 Wochen nach Beginn einer antiepileptischen Behandlung an einem Carbamazepin-induzierten Hypersensitivitätssyndrom, bestehend aus therapieresistentem Fieber, polymorphem Exanthem, oropharyngealen Läsionen, generalisierter Lymphadenopathie, Hepatosplenomegalie und Nephritis, erkrankte. Wir fanden positive Lymphozytenstimulations- und Epikutantests auf Carbamazepin als Ausdruck einer spezifischen Überempfindlichkeit. Spezifische Anti-Carbamazepin-Antikörper, zirkulierende Immunkomplexe oder eine Komplementerniedrigung waren nicht nachweisbar. Es handelt sich um eine Überempfindlichkeitsreaktion unbekannter Ätiologie im Sinn einer Idiosynkrasie. Nach Ausschluß infektiöser Ursachen wird die Differentialdiagnose zu anderen Systemerkrankungen erörtert. Diskussion: Neben aromatischen Antikonvulsiva (Carbamazepin, Phenobarbital, Phenytoin) sind Sulfonamide und Goldsalze mögliche Auslöser eines Hypersensitivitätssyndroms. Absetzen des Induktors und systemische Kortikosteroide führen in der Regel zur vollständigen Remission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050110
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    Paper (German National Licenses)
    Fulltext
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