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  • 1
    Electronic Resource
    Electronic Resource
    Malignant Paraganglioma Metachronously Recurring at Short Duration in Different Paraganglions: Report of a Case (1999)
    Springer
    Surgery today 29 (1999), S. 769-772 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: malignant paraganglioma ; retroperitoneum ; multicentric growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050507
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pancreatic arteriovenous malformation observed to bleed from the bile duct and a duodenal ulcer: Report of a case (1999)
    Springer
    Surgery today 29 (1999), S. 462-466 
    Details
    ISSN: 1436-2813
    Keywords: pancreatic ; arteriovenous ; malformation ; hemobilia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 48-year-old man with recurrent episodes of biliary colic and subsequent pancreatitis was admitted to undergo a cholecystectomy. A gastroduodenal fiberscopic examination was performed because of massive melena on the seventh day after adminission. It revealed a shallow ulcer on the posterior wall of a duodenal bulbus with rubor and an exposed vessel, which was clipped endoscopically to stop the bleeding. Further observations showed the papilla of Vater to be bleeding from the papilla. A contrast-enhanced abdominal computed tomography scan demonstrated a dilatation of the common bile duct and several dilated vasculatures around the portal vein, some of which drained into the portal vein. Based on the angiography findings, a diagnosis of arteriovenous malformation in the pancreas head was obtained and an embolization of the gastroduodenal artery was performed. Although the melena subsided, he underwent a pylorus-preserving pancreatoduodenectomy to prevent the recurren of hemorrhaging. The histopathological findings of the bile duct revealed inflammatory cell infiltration and a detachment of the epithelium, except in a small part of the bile duct. A rupture of a damaged vessel inside the bile duct was observed, which was thought to be the cause of hemobilia. Sections of the pancreatic head demonstrated an, inflammatory lesion with fibrosis and saponification as well as a large degree of arteriovenous anastomosis. The patient was discharged on the 35th day after the operation following an uneventful postoperative course.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02483042
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Metachronous Triple Cancers of the Sigmoid Colon, Stomach, and Esophagus: Report of a Case (2000)
    Springer
    Surgery today 30 (2000), S. 368-371 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: triple cancer, colon cancer, gastric cancer, esophageal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: We report herein an unusual case of metachronous triple cancers of the sigmoid colon, stomach, and esophagus. A 60-year-old man was initially admitted to our hospital for investigation of occult fecal blood. This was found to be caused by sigmoid colon cancer which was resected in July 1985 (T3, N0, M0; Stage II). A follow-up endoscopy performed in 1990 showed early gastric cancer, and a gastrectomy was performed in August 1990 (Tis, N0, M0; Stage 0). Another endoscopic examination performed as follow-up in 1993 revealed early cancer of the remnant stomach, and all the remnant stomach was surgically resected in March 1993 (Tis, N0, M0; Stage 0). He presented again in December 1996, complaining of discomfort in the chest which was found to be caused by cancer of the middle thoracic esophagus. Although surgery was considered necessary, the patient refused to undergo any further operations. Instead, radiation was administered from January 1997. An endoscopy after the completion of radiotherapy confirmed that the cancer had almost disappeared; however, it started to grow again from the beginning of 1998. He was hospitalized due to esophageal stenosis in April 1998, and died of carcinomatous cachexia in September of the same year.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050602
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Pancreatic Arteriovenous Malformation Observed to Bleed from the Bile Duct and a Duodenal Ulcer: Report of a Case (1999)
    Springer
    Surgery today 29 (1999), S. 462-466 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: pancreatic arteriovenous malformation ; hemobilia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050444
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Relation between K-ras codon 12 mutation and p53 protein overexpression in gallbladder cancer and biliary ductal epithelia in patients with pancreaticobiliary maljunction (2000)
    Springer
    Journal of hepato-biliary-pancreatic surgery 7 (2000), S. 198-205 
    Details
    ISSN: 1436-0691
    Keywords: Key words: pancreaticobiliary maljunction, K-ras oncogene mutation, overexpression of p53 protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: It is well known that the incidence of biliary cancer is higher in patients with pancreaticobiliary maljunction (PBM) than in individuals without PBM. However, the relationship between PBM and the carcinogenesis remains unclear. The purpose of the present study was to examine histopathologic changes in the mucosa of the gallbladder and bile duct in patients with PBM, and to investigate K-ras oncogene mutation and overexpression of p53 protein in the mucosa. We examined 47 surgical specimens of gallbladder and 36 surgical specimens of bile duct obtained from 48 patients with PBM. The 48 patients were divided into three age groups: group A (0–3 years), group B (4–39 years), and group C (40 years or more). Investigation of K-ras mutation and overexpression of p53 protein was performed using an enriched polymerase chain reaction (PCR) and enzyme-linked mini-sequence assay (ELMA), and by the streptavidin-biotin (SAB) method, using DO-7 antibodies, respectively. Hyperplastic changes in the gallbladder mucosa were observed in patients in the three groups. However, metaplastic or dysplastic changes were observed in the mucosa of only groups B and C. K-ras gene mutation in the gallbladder mucosa was found in 18.8% of the hyperplastic mucosae in group B and in 20% in group C. The mutation was found in 33.3% of lesions with metaplastic change associated with hyperplastic changes and in 25% of lesions with dysplastic changes in group C. No mutation was observed in the non-cancerous mucosae of gallbladders and bile ducts without congenital dilatation of the bile duct. Overexpression of p53 protein was observed only in carcinoma of the gallbladder; in seven of nine advanced carcinomas and in two of three carcinomas in situ. We concluded that the mucosal epithelia of the biliary system in patients with PBM showed a high frequency of gene mutations and the carcinogenesis appeared in involve a multistage process of mutation in the K-ras gene and the p53 supressor gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005340050176
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  • 6
    Electronic Resource
    Electronic Resource
    Nuclear accumulation of beta-catenin in intestinal-type gastric carcinoma: correlation with early tumor invasion (2000)
    Springer
    Virchows Archiv 437 (2000), S. 508-513 
    Details
    ISSN: 1432-2307
    Keywords: Gastric carcinoma Beta-catenin Nuclear accumulation Mutational analysis Invasive front
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Mutation of the adenomatous polyposis coli gene, which is known to be an early event in the carcinogenesis of intestinal-type gastric carcinoma, leads to accumulation of beta-catenin. In addition, beta-catenin has been found to activate down stream signaling molecules in the wingless/Wnt pathway. In this study, the clinical significance of nuclear accumulation of beta-catenin was evaluated in gastric carcinoma. Immunohistochemical staining showed nuclear localization in 16 (12%) of 139 (94 intestinal-type and 45 diffuse-type) gastric carcinomas, and all 16 lesions with nuclear staining were intestinal-type adenocarcinomas. Of the 16 cases, 15 were in the early clinical stage. In the remaining case, the lesion had invaded the subserosal layer and showed strong nuclear staining at the invasive front. In 14 of the 16 cases with nuclear localization, there were no abnormal mobility shifts detected using polymerase chain reaction-single strand conformational polymorphism analysis. This was confirmed using direct sequencing analysis, which revealed the wild-type sequence in the 12 cases tested. Nuclear accumulation of beta-catenin did not correlate with lymph node metastasis or 5-year survival. These findings suggest that high intranuclear levels of beta-catenin protein play an important role in early tumor growth and may function in initiation of invasive processes in intestinal-type gastric carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280000283
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    Paper (German National Licenses)
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