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  • 1
    Electronic Resource
    Electronic Resource
    Differential Regulation of Intracellular Signaling Systems by Sodium Fluoride in Rat Glioma Cells (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 66 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: We investigated the rapid and slow effects of NaF on intracellular signaling systems such as Ca2+ homeostasis and cyclic GMP (cGMP) generation in rat glioma C6 cells, using the Ca2+-sensitive dye fura-2 and cGMP enzyme immunoassay. We found that the following: (a) NaF enhanced cGMP generation in a concentration-dependent manner. This enhancement was abolished by pretreatment with 100 µM BAPTA tetraacetoxymethyl ester or in the presence of W-7 in a concentration-dependent manner. NG-Monomethyl-l-arginine (NMMA), a competitive inhibitor of nitric oxide synthase (NOS), also inhibited the NaF-induced generation of cGMP. These results suggest that NaF-induced cGMP generation occurs via a calcium/calmodulin- and NOS-dependent pathway. (b) The basal intracellular Ca2+ concentration ([Ca2+]i) was transiently greater at 1 and 3 h after pretreatment with NaF. W-7 and W-13 antagonized the increase in [Ca2+]i, whereas NMMA had little effect. This suggests that the NaF-induced change in basal [Ca2+]i was mediated by a calmodulin-dependent pathway but was independent of a NOS-sensitive pathway. (c) The serotonin (5-HT)-induced intracellular mobilization of Ca2+ was reduced by pretreating the cells with NaF. The reduction in Ca2+ mobilization was antagonized by genistein, a tyrosine kinase inhibitor. W-7, W-5, and H-8 had no effect. Results suggest that NaF differentially regulates the cGMP generation, basal [Ca2+]i, and 5-HT2A receptor function in C6 glioma cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.66041483.x
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  • 2
    Electronic Resource
    Electronic Resource
    Predictive factors for psychological distress in ambulatory lung cancer patients (1998)
    Springer
    Supportive care in cancer 6 (1998), S. 281-286 
    Details
    ISSN: 1433-7339
    Keywords: Key words Lung cancer ; Psychological distress ; Coping ; Social support
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Although there is a need for systematic research on the psychosocial issues faced by lung cancer patients, there have been few studies in this area. The objective of the present study was to investigate potential predictors of psychological distress among ambulatory lung cancer patients. The variables examined included the patients' characteristics, coping responses, and social support factors. Lung cancer patients completed the Profile of Mood States (POMS) and the Mental Adjustment to Cancer scale (MAC scale), and information pertaining to demographic variables and social support factors was obtained from them at a structured interview. Evaluable data were obtained from 87 patients. The results of multiple regression analysis indicated that female gender, living alone, no children in the role of confidant, nurses as confidants, and helplessness/hopelessness as a coping style were predictive for psychological distress. Information on patients' demographic variables and psychosocial correlates of psychological distress may later be useful in developing interventions to facilitate their adjustment to lung cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005200050167
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  • 3
    Electronic Resource
    Electronic Resource
    Successful antidepressant treatment for five terminally ill cancer patients with major depression, suicidal ideation and a desire for death (1999)
    Springer
    Supportive care in cancer 7 (1999), S. 432-436 
    Details
    ISSN: 1433-7339
    Keywords: Key words Suicidal thought ; Desire for death ; Major depression ; Antidepressant ; Terminally ill cancer patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  In the debate on euthanasia and physician-assisted suicide, we have to exclude terminally ill patients in whom the desire for death is caused by major depression. However, it is still not clear to what degree major depression can be treated by psychiatric intervention in this setting. We evaluated the effect of antidepressant treatment in terminally ill cancer patients. Six cancer patients with suicidal ideas thought to be due to major depression were treated with tricyclic antidepressants. Three had requested terminal sedation to relieve them from their suffering. The median survival of five of these patients was 4 weeks after diagnosis; one was lost to follow-up. The efficacy of the antidepressant treatment was assessed using the Hamilton Rating Scale for Depression (HRSD). One week after the start of treatment with antidepressants, five of the six patients showed a marked improvement in their mood and showed no further suicidal thoughts or requests for terminal sedation. The average reduction in the HRSD score was 23.4 points (14–38; SD = 9.9). Antidepressant treatment can be effective in alleviating the desire for death due to major depression, even in terminally ill cancer patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005200050305
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  • 4
    Electronic Resource
    Electronic Resource
    Patients' understanding of their own disease and survival potential in patients with metastatic breast cancer (2000)
    Springer
    Breast cancer research and treatment 61 (2000), S. 131-137 
    Details
    ISSN: 1573-7217
    Keywords: clinical trial ; informed consent ; metastatic breast cancer ; survival ; understanding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: To investigate the effect of understanding their own disease by patients with metastatic breast cancer on their survival potential after being informed by their physician. Patientsandmethods: Two hundred and fourteen women with metastatic breast cancer who participated in a multi-institutional, randomized phase III trial (Japan Clinical Oncology Group (JCOG) Study 8808) were asked whether they understood their own disease after being given information about the clinical trial. They were classified into two groups on the basis of whether they understood or not. We estimated their survival after the time of registration and derived relative hazard ratios from Cox's proportional hazards model. Results: There were 190 patients in the ‘better understanding’ group and 24 in the ‘poor understanding’ group. Median survival times after registration were 28.3 and 16.1 months, respectively. The ‘better understanding’ group showed a significant difference from the ‘poor understanding’ group (p=0.016). In multivariate regression analysis, patients who did not understand still showed poorer survival than those who understood (hazard ratio = 2.09; 95% confidence interval (CI) 1.16–3.78; p=0.014)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006491417791
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    Paper (German National Licenses)
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