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  • 1
    Electronic Resource
    Electronic Resource
    Accuracy of oscillometric blood pressure measurement in critically ill neonates with reference to the arterial pressure wave shape (1996)
    Springer
    Intensive care medicine 22 (1996), S. 242-248 
    Details
    ISSN: 1432-1238
    Keywords: Blood pressure measurement ; Radial artery pressure ; Wave form ; Oscillometry ; Newborn infant ; Intensive care
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To perform further evaluation of the oscillometric device for neonatal arterial blood pressure (ABP) measurement, using a catheter-manometer system (CMS) for accurate intraarterial measurement. We aimed to describe the influence of the radial artery wave shape on oscillometric ABP determination, as pressure, wave-shape influences the relationships between systolic arterial pressure (SAP),diastolic arterial pressure (DAP) and mean arterial pressure (MAP) in the wave. These relationships are part of the algorithms contributing to the final ABP determination in the oscillometric device. Design Intra-patient comparison of two blood pressure measurement systems. Setting Neonatal intensive care unit. Patients In 51 critically ill newborn infants, ABP was determined oscillometrically in the brachial artery and, simultaneously, invasively in the radial artery using a high-fidelity CMS. Clinical data of the infants were: gestational age: 29 (25–41) weeks; brithweight: 1200 (500–3675) g, postnatal age: 6 (2–46) h. Methods Statistical analysis was performed with the paired Student'st-test. Multiple regression analysis was used to determine the influence of birthweight and height of the blood pressure on the results. Measurements and main results In 51 infants, 255 paired values of SAP, DAP and MAP were recorded. In all recordings we determined the relationship between SAP, DAP and MAP, using the equation. MAP=α%(SAP-DAP)+DAP. For SAP, DAP, MAP and α, we computed mean differences (bias) and the limits of agreement (precision). Biases for SAP, DAP, MAP and α were significantly different from zero (P〈0.001) and the limits of agreement for SAP, DAP and MAP were wide: 18.8 mmHg, 17.2 mmHg and 15.2 mmHg respectively The relationship between invasive and noninvasive values is only partly (7–19%) influenced by the height of the blood pressure; low values of SAP, DAP and MAP tend to give overestimated oscillometric values. In the relationship between SAP, DAP and MAP, α was found to be 47% invasively (as generally found in the radial artery in newborns) and 34% noninvasively (as generally found in the brachial/radial artery in adults). Conclusions Inaccuracy of the oscillometric device may be partly explained by the incorporation of an inappropriately fixed algorithm for final ABP determination in newborns. Care should be taken when interpreting the oscillometrically derived values in critically ill newborn infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712244
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  • 2
    Electronic Resource
    Electronic Resource
    Accuracy of oscillometric blood pressure measurement in critically ill neonates with reference to the arterial pressure wave shape (1996)
    Springer
    Intensive care medicine 22 (1996), S. 242-248 
    Details
    ISSN: 1432-1238
    Keywords: Key words Blood pressure measurement ; Radial artery pressure ; Wave form ; Oscillometry ; Newborn infant ; Intensive care
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   Objective: to perform further evaluation of the oscillometric device for neonatal arterial blood pressure (ABP) measurement, using a catheter-manometer system (CMS) for accurate intraarterial measurement. We aimed to describe the influence of the radial artery wave shape on oscillometric ABP determination, as pressure wave-shape influences the relationships between systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and mean arterial pressure (MAP) in the wave. These relationships are part of the algorithms contributing to the final ABP determination in the oscillometric device. Design Intra-patient comparison of two blood pressure measurement systems. Setting Neonatal intensive care unit. Patients In 51 critically ill newborn infants, ABP was determined oscillometrically in the brachial artery and, simultaneously, invasively in the radial artery using a high-fidelity CMS. Clinical data of the infants were: gestational age: 29 (25–41) weeks; birthweight: 1200 (500–3675) g, postnatal age: 6 (2–46) h. Methods Statistical analysis was performed with the paired Student’s t-test. Multiple regression analysis was used to determine the influence of birthweight and height of the blood pressure on the results. Measurements and main results In 51 infants, 255 paired values of SAP, DAP and MAP were recorded. In all recordings, we determined the relationship between SAP, DAP and MAP, using the equation: MAP=α%(SAP−DAP)+DAP. For SAP, DAP, MAP and α, we computed mean differences (bias) and the limits of agreement (precision). Biases for SAP, DAP, MAP and α were significantly different from zero (P〈0.001) and the limits of agreement for SAP, DAP and MAP were wide: 18.8 mmHg, 17.2 mmHg and 15.2 mmHg respectively. The relationship between invasive and noninvasive values is only partly (7–19%) influenced by the height of the blood pressure; low values of SAP, DAP and MAP tend to give overestimated oscillometric values. In the relationship between SAP, DAP and MAP, α was found to be 47% invasively (as generally found in the radial artery in newborns) and 34% noninvasively (as generally found in the brachial/radial artery in adults). Conclusions Inaccuracy of the oscillometric device may be partly explained by the incorporation of an inappropriately fixed algorithm for final ABP determination in newborns. Care should be taken when interpreting the oscillometrically derived values in critically ill newborn infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712244
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  • 3
    Electronic Resource
    Electronic Resource
    Bronchoscopic treatment of necrotising tracheo-bronchitis in a newborn (1986)
    Springer
    European journal of pediatrics 144 (1986), S. 596-597 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496046
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  • 4
    Electronic Resource
    Electronic Resource
    Calculated mean arterial blood pressure in critically ill neonates (1993)
    Springer
    Basic research in cardiology 88 (1993), S. 80-85 
    Details
    ISSN: 1435-1803
    Keywords: Radial artery pressure ; systolic pressure ; diastolic pressure ; pulse pressure ; newborn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mean arterial pressure (MAP) is the area under the pressure wave form averaged over the cardiac cycle. A widely used rule of thumb to estimate MAP of peripheral arterial pressure waves in adults is adding one-third of the pulse pressure (PP) to diastolic arterial pressure (DAP). However, radial artery pressure waves in newborns differ from those in adults and resemble proximal aortic pressure waves, so that the above-mentioned calculation of MAP may not be correct. The present study was set up to obtain an arithmetical approximation to derive MAP from blood pressure waves measured in the radial artery of the neonate. We accurately recorded about 300 invasively obtained blood pressure curves in the radial artery of 10 neonates admitted for intensive care. We found that MAP in the radial artery in these neonates can be well approximated by adding 46.6% PP to DAP (range 43.0–50.1%). We suggest that the rule of thumb to derive MAP from radial artery waves in the neonate to be approximately the average of systolic and diastolic pressure, as opposed to adding one-third of the pulse pressure to the diastolic value in the adult.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00788533
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  • 5
    Electronic Resource
    Electronic Resource
    Value of fluid-attenuated inversion recovery sequences in early MRI of the brain in neonates with a perinatal hypoxic-ischemic encephalopathy (2000)
    Springer
    European radiology 10 (2000), S. 1594-1601 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Neonates – Hypoxic-ischemic brain injury – Myelination – MRI – FLAIR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of our study was to assess the usefulness of fluid-attenuated inversion recovery (FLAIR) sequences in comparison with conventional spin-echo and inversion MR imaging in neonates for evaluation of myelination and for detection of hypoxic-ischemic brain injury. We reviewed early MR scans of 18 neonates with suspected hypoxic-ischemic brain damage. Myelination could be evaluated with confidence using conventional MR imaging in all but 2 infants; however, the presence of myelin was very difficult to assess on FLAIR images. Overall, 53 lesions or groups of lesions were identified. The FLAIR technique was more sensitive in 11 of the lesions; especially (pre)cystic lesions could be identified much better and more cysts were found. Conventional MR imaging failed to identify 2 of the lesions and was more sensitive in 14 of the lesions; especially punctate hemorrhages and lesions in basal ganglia or thalami could be better determined. The FLAIR technique missed 3 of these lesions. In the remaining 28 lesions conventional MR and FLAIR images were equally diagnostic. The FLAIR technique and conventional MR imaging are complementary in detecting early sequelae of hypoxic-ischemic brain injury in neonates. The FLAIR technique is not suitable for assessing myelination of the neonatal brain; therefore, FLAIR cannot replace conventional MR imaging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300000482
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  • 6
    Electronic Resource
    Electronic Resource
    Calculated mean arterial pressure in the posterior tibial and radial artery pressure wave in newbown infants (1995)
    Springer
    Basic research in cardiology 90 (1995), S. 247-251 
    Details
    ISSN: 1435-1803
    Keywords: intra-arterial pressure ; mean arterial pressure ; radial artery ; tibial artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mean arterial pressure (MAP) is the area under the pressure wave averaged over the cardiac cycle, and therefore depends on pressure wave contour. A generally used rule of thumb to estimate MAP of peripheral arteries in adults is adding one-third of the arterial pulse pressure (PP) to diastolic arterial pressure (DAP). As peripheral pressure wave forms in neonates do not resemble adult peripheral wave forms, it may be expected that this rule of thumb does not hold for neonates. Previously, we found that MAP can be calculated by adding 50% PP to DAP in radial artery waves in neonates. In the present study, we investigated in neonates how MAP in the posterior tibial artery depends on systolic and diastolic pressure and we compared these findings to those found in the radial artery. Forty infants admitted for intensive care were studied. We analyzed 5000 invasively and accurately obtained blood pressure waves in the posterior tibial artery of 20 neonates and another 5000 waves similarly obtained from the radial artery in another group of 20 neonates. We found that MAP in posterior tibial artery waves is well approximated by adding 41.5±2.0% of PP to DAP, whereas MAP in radial artery waves can be calculated by adding 46.7±1.7% of PP to DAP. These values are significantly different (p〈0.0001). In conclusion, the rule of thumb as used in the adult to find MAP, where 33% PP is added to DAP, does not hold for the newborn. We recommend to calculate MAP in the tibial artery by adding 40% of PP to DAP and in the radial artery by adding 50% of PP to DAP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00805668
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  • 7
    Electronic Resource
    Electronic Resource
    Simultaneous determination of concentrations and stable isotope enrichments of α-ketoisocaproic acid, leucine, phenylalanine and tyrosine in blood plasma by gas chromatography/negative ion mass spectrometry (1995)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 30 (1995), S. 1260-1266 
    Details
    ISSN: 1076-5174
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A simple procedure for the extraction and derivatization of α-amino acids and α-keto acids from human plasma is described. This stable isotope dilution method permits the quantification of isotopic enrichment and concentrations of several α-keto and α-amino acids simultaneously. The derivatization process results in methylformated, pentafluorobenzylated α-amino acids and pentafluorobenzylated α-keto acids. The derivatives proved to be very stable when stored at 5°C. Under electron capture chemical ionization (ECCI) conditions the derivatized amino acid produces abundant [M - PFB]- or [M - PFB - CH3OH]- anions; the α-keto acid gives abundant [M - PFB]- anions. The method was applied to the analyses of 100 μl plasma samples in studies on protein metabolism. For the determination of concentrations [α-ketoisocaproic acid (α-KIC), Leu, Phe and Tyr] and enrichments ([1-13C]-α-KIC, [1-13C]-Leu, D5-Phe, D2-Tyr, D4-Tyr), resulting from administered tracers, the corresponding [M - PFB]- or [M - PFB - CH3OH]- anions were monitored. Higher labelled analogues were used as internal standards. The overall sensitivity was sufficient to study isotopic enrichments in the range 0.2-10 at.% excess.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jms.1190300908
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  • 8
    Electronic Resource
    Electronic Resource
    Construction and performance of a new catheter-tip oxygen electrode (1978)
    Springer
    Medical & biological engineering & computing 16 (1978), S. 274-277 
    Details
    ISSN: 1741-0444
    Keywords: Oxygen monitor ; Palarography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Est décrit un système d'électrode à oxygène munie d'un embout cathéter et recouverte d'une, membrane, donnant une réponse linéaire dans la gammeP o2 de O à 350 mm Hg. Ce système est extrêmement stable, exempt de dérive et du point de vue mécanique il ne présente aucun danger d'application sur l'homme. Une telle sûreté d'application est obteneue en utilisant un capuchon à vis pour fixer le support de membrane, permettant ainsi d'éviter la perte de pièces et assurant l'étanchéité complète de la chambre électrolytique. Grâce au verre isolante le fil de platine, toute possibilité de contact entre le fluide et l'anode d'argent au-delà du niveau de mesure de l'embout est exclue.
    Abstract: Zusammenfassung Beschrieben wird ein membranumhulltes Sauerstoffelektrodensystem mit Katheterspitze, das imP o2-Bereich von 0–350 mm Hg eine Linearreaktion aufweist. Das System ist mechanisch sehr stabil, frei von Nullpunktverschiebung und kann gefahrlos im Menschen angewendet werden. Dies wird durch Verwendung einer Schraubenkappe zur Befestigung des Membranhalters ermöglicht, was das Verlorengehen von Bestandteilen ausschaltet und die Elektrolytenzelle wirklich flüssigkeitsdicht macht. Glasisolierung des Platindrahtes schließt die Möglichkeit eines Flüssigkeitsbrückenkontaktes mit der Silberanode außerhalb der Meßstelle an der Spitze aus.
    Notes: Abstract A membrane-covered catheter-tip oxygen-electrode system is described, which gives a linear response in the Po2 range of 0–350 mm Hg. The system is highly stable, free from drift and mechanically safe for application in man. This is accomplished by using a screw cap for fastening the membrane holder, thus preventing the loss of parts and making the electrolyte chamber really fluidtight. Insulation of the platinum wire with glass precludes the possibility of fluid-bridge contact with the silver anode beyond the measuring site at the tip.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02442427
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