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  • 1
    Electronic Resource
    Electronic Resource
    The Pepsinogen Releasing Effect of Helicobacter pylori Lipopolysaccharide (2002)
    Oxford, UK : Blackwell Science Ltd
    Helicobacter 7 (2002), S. 0 
    Details
    ISSN: 1523-5378
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background. Helicobacter pylori lipopolysaccharide (LPS) affects pepsinogen release by a nontoxic mechanism. We hypothesized that this effect was characteristic of the organism and related to the clinical status of the strain.Materials and methods. LPS was isolated from 11 H. pylori strains whose pathogenic profile was known and four other nongastric bacteria. The effects of luminal LPS on guinea pig gastric mucosal pepsinogen release was evaluated using the Ussing chamber technique. CCK-8 (10−9M) was used as a positive control.Results. H. pylori LPS dose-dependently stimulated pepsinogen release with a maximal stimulation at 250 µg/ml (~4500%; p 〈 .001 vs. control). LPS from other Helicobacter or Campylobacter species had no effect on pepsinogen release. ANOVA demonstrated significant differences in the efficacies of pepsinogen release between the 11 clinical H. pylori strains (p 〈 .0001) despite the fact that they were all cagA+ and 90% had the cytotoxic vacA subtype s1. Physical and chemical disruption of the LPS suggested that both the structure and the carbohydrate composition of this molecule may play a critical role in pepsinogen release. Polymyxin B partly (p 〈 .03) inhibited and dephosphorylation completely inhibited (p = .0002) LPS-stimulated pepsinogen release.Conclusion. Pepsinogen release is an innate property of all cagA+H. pylori LPS. The structure of the molecule and composition of side-chains are important in this response which appears to be partially lipid A driven.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1523-5378.2002.00053.x
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  • 2
    Electronic Resource
    Electronic Resource
    In vitro susceptibility of“Campylobacter upsaliensis” to twenty-four antimicrobial agents (1990)
    Springer
    European journal of clinical microbiology & infectious diseases 9 (1990), S. 822-824 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The in vitro susceptibility of 41 strains of“Campylobacter upsaliensis” to 24 antimicrobial agents was determined using a broth microdilution procedure. Most isolates were susceptible to the fluoroquinolones and β-lactam antibiotics tested, but all strains were resistant to trimethoprim (MBCs ≥ 128 µg/ml) and teicoplanin (MBCs ≥ 32 µg/ml). These agents may be useful in a selective isolation medium for“Campylobacter upsaliensis”.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967382
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Microfilaments inNaegleria fowleri amoebae (1976)
    Springer
    Parasitology research 50 (1976), S. 245-250 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Examination by electron microscopy has revealed 2 types of microfilament in the cytoplasm of 3 strains of axenically grownNaegleria fowleri amoebae. Thin, actin-like microfilaments 5–7 nm in diameter are randomly oriented in the nonmotile amoebae, and are concentrated near the plasma membrane. In the actively motile amoebae these microfilaments aggregate to form colateral bundles in close proximity to the plasma membrane. Thick, myosin-like microfilaments 17–19 nm in diameter also occur in the amoebae cytoplasm. The significance of these 2 kinds of microfilament in amoeboid motion is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02462969
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    Paper (German National Licenses)
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