ISSN:
1432-2072
Keywords:
5HT3antagonist
;
Generalized Anxiety Disorder
;
Clinical trial
;
Placebo-controlled
;
Hamilton Anxiety Scale
;
Hopkins Symptom Check List
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The selective 5HT3 antagonist tropisetron was studied in 91 outpatients meeting DSM-III criteria for Generalized Anxiety Disorder. Following a placebo washout period of up to 1 week, one of three active treatments (tropisetron 0.5 mg, 5 mg, or 25 mg daily) or placebo was given for a further 3 weeks. After 7 days treatment termination rates due to inefficacy showed a statistically significant dose-related therapeutic effect of tropisetron. Similar effects were seen on the Hopkins Symptom Check List total score and the Global Impression Scale. The Hamilton Anxiety Scale showed a similar trend which, however, failed to reach statistical significance. At day 21 tropisetron showed significant dose-dependent effects on all anxiety-related outcome measures. The incidence of adverse events was low and the severity generally mild. Most frequent complaints were headache, nausea, constipation and nervousness. Laboratory tests and physical examination performed at baseline and study end showed no significant treatment effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02247373
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