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  • 1
    Electronic Resource
    Electronic Resource
    The effects of 5-bromodeoxyuridine (BrdU) on morphogenesis of the early chick embryo (1974)
    Springer
    Development genes and evolution 174 (1974), S. 102-106 
    Details
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The effects of BrdU (3×10−4 M) on morphogenesis of the chick embryo explanted at the definitive streak stage and cultured for 24 hours were studied. Compared to controls treated embryos often showed (1) an open neural tube and (2) less numerous somites. Heart development was not significantly affected by BrdU. The damage caused by BrdU was not permanent, i.e., the embryos retained the ability to undergo fairly normal morphogenesis when, after 4–5 hours of BrdU treatment, they were subcultured on a medium with excess thymidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00577060
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Neural tube formation in the mouse: a morphometric and computerized three-dimensional reconstruction study of the relationship between apical constriction of neuroepithelial cells and the shape of the neuroepithelium (1990)
    Springer
    Anatomy and embryology 181 (1990), S. 49-58 
    Details
    ISSN: 1432-0568
    Keywords: Microfilaments ; Cytoskeleton ; Morphometry ; Neurulation ; 3D reconstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Morphornetry and computerized three-dimensional reconstruction were used to study the relationship between apical constriction of neuroepithelial cells and the pattern of bending of the neuroepithelium in the developing neural tube of the 12-somite mouse embryo. The neuroepithelium of the mouse exhibits prominent regional variations in size and shape along the embryo axis. The complex shape of most of the cephalic neural tube (e.g., forebrain and midbrain) is due to the coexistence of concave and convex bending sites whereas more caudal regions (e.g., hindbrain and spinal cord) generally lack sites of convex bending and have a relatively simple shape. The apical morphology of neuroepithelial cells was found to be correlated more closely with the local status of bending of the neuroepithelium than with the specific region of the neural tube in which they are located. In areas of enhanced apical constriction, microfilament bundles were particularly prominent. Morphornetry revealed that patterns of bending of the neuroepithelium were correlated almost exactly with those of apical constriction throughout the forming neural tube. These findings support the idea that apical constriction of neuroepithelial cells, resulting from tension generated by microfilament bundles, plays a major role in bending of the neuroepithelium during neural tube formation in the mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00189727
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  • 3
    Electronic Resource
    Electronic Resource
    Diazepam Enhances Ca2+ Levels in Rat Brain Synaptosomes (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 635 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb36518.x
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  • 4
    Electronic Resource
    Electronic Resource
    X-ray absorption spectroscopic studies of sputter-deposited LaNiO3 thin films on Si substrate (1996)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 2175-2180 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: X-ray absorption spectroscopy (XAS) was applied to investigate the growth behavior of LaNiO3 thin films on Si substrate deposited via radio frequency magnetron sputtering at high temperature. The thickness of deposited film was always proportional to the sputtering time. However, the Ni-to-La ratio in the film was found to decrease with increasing substrate temperature. It is due to a loss of Ni on high-temperature deposition which lowers the film growth rate and leads to a gradual structural change. Nevertheless, the oxidation states of both Ni atom and La atom in the thin films were not influenced by the substrate temperature or sputtering time. All the XAS evidence was consistent with the results from x-ray reflectivity, x-ray diffraction, and chemical analysis. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.363109
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  • 5
    Electronic Resource
    Electronic Resource
    A radioautographic study of neural induction in the chick embryo (1973)
    Springer
    Cellular and molecular life sciences 29 (1973), S. 332-334 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Gebiete aus dem Hensen'schen Knoten wurden implantiert, wobei dessen DNA-RNA mit Uridin-H3 markiert wurde. Die induzierten Neuralanlagen enthielten kaum markierte Substanzen, und wenn, dann nur im Bereich der Kontaktstellen, woraus folgt, dass andere Substanzen für die Induktion verantwortlich sein müssen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01926511
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  • 6
    Electronic Resource
    Electronic Resource
    A morphometric and computer-assisted three-dimensional reconstruction study of neural tube formation in chick embryos (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 231 (1991), S. 425-436 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The origin of the driving forces for neural tube formation remains uncertain but is currently thought to involve the participation of microfilament bundles situated in the apical ends of neuroepithelial cells. In the work presented here, we show how morphometric measurements that map local variations in the apical geometry of neuroepithelial cells (especially apical constriction) can provide information on the distribution of motive forces within the neuroepithelium during neural tube formation. When used in combination with computer-assisted, three-dimensional reconstruction, it becomes possible to analyze the morphometric data from a dynamic, three-dimensional perspective. As an example application of this method, we have used morphometry to evaluate the effects of ionomycin on the developing neuroepithelium. Treatment of early (stages 6-8) chick embryos with 5 μM ionomycin was found to cause rapid bending of the neuroepithelium within 1 min of exposure and a dramatic acceleration of the normal sequence of neural tube formation. Electron microscopy and morphometry revealed that this acceleration was coincident with a marked increase in the local degree of apical constriction of neuroepithelial cells, presumably a consequence of enhanced contractile activity of apical microfilament bundles. This work shows that transient elevation of free calcium levels can accelerate the usualal sequential phases of NT formation. The rapidity of the response (hours of normal development reduced to minutes), increased prominence of apical microfilament bundles, and the enhanced degree of apical constriction strongly support a direct causal role for apical microfilament bundles and apical constriction of neuroepithelial cells in bending of the neuroepithelium.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092310405
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