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  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 11 (1990), S. 297-318 
    ISSN: 0163-7525
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 14 (1993), S. 219-241 
    ISSN: 0163-7525
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Public Health 7 (1986), S. 217-235 
    ISSN: 0163-7525
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 15 (2003), S. 0 
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thyroid hormone is an essential modulator of brain development, but little is known about its actions in the adult brain. Hypothyroidism is associated with gene expression changes in both central and peripheral nervous tissue. Functional consequences of adult-onset hypothyroidism include an inability to produce long-term potentiation in rat hippocampus and impaired learning and memory in both rats and man. Long-term potentiation is a form of learning that is dependent on functional N-methyl-d-aspartic acid (NMDA)-preferring ionotropic glutamate receptors. This work examines the expression of ionotropic glutamate receptor subunit mRNA following surgical thyroidectomy with or without thyroid hormone replacement. In situ hybridization histochemistry was used to determine the mRNA levels of the NMDA receptor subunits NR1, NR2A, NR2B, the AMPA receptor subunit GluR1, and the kainate receptor subunit KA2. Reducing circulating concentrations of thyroid hormone by surgical removal of the thyroid gland 2 weeks before sacrifice decreased the expression of NR1 mRNA exclusively in the hippocampus. Conversely, hyperthyroidism selectively reduced NR2B mRNA expression in the dorsal hippocampus. Altering thyroid hormone status had no effect on the expression of KA2 or GluR1 subunit mRNA. The regulation of expression of NR1 and NR2B mRNA by thyroid hormone is a novel mechanism for explaining the relationship between thyroid hormone and cognitive function.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 21 (1996), S. 59-63 
    ISSN: 0721-3115
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A well-characterized shaped charge was used to study the influence of asymmetrical initiation on the jet. An experimental study yielded flash radiographs of the jets from charges fired with the initiation point offset 2, 4, 6, 8 and 10 mm, respectively, from the central axis. The axial and lateral velocities of the jet particles were determined from the sets of radiographs. In a previous paper it was hypothesized that a simple relationship might exist between the departure vectors of the jet particles and the geometry of the impingement of the detonation front on the liner. Any part of the jet from an asymmetrically initiated shaped charge departs at an angle determined by the difference between the current angle between the actual detonation wave where it contacts the liner, and that which would have arisen had the initiation been perfectly axial. We set up a simple computer code which evaluates, for any given initiation offset distance, the instantaneous angles between the detonation front and the successive elements of the liner which are encountered as the wave sweeps along it. Since it is possible to map particle velocities in the jet on to those regions of the liner where they originated, simulated sets of axial and lateral jet velocities were readily generated. Agreement between theory and experiment is sufficiently close to suggest that our approximation is useful and can assist in understanding the jet dynamics of asymmetrically initiated shaped charges.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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