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  • 1
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We have analysed 118 families with inherited medullary thyroid carcinoma (MTC) for mutations of the RET proto–oncogene. These included cases of multiple endocrine neoplasia types 2A (MEN 2A) and 2B (MEN 2B) and familial MTC (FMTC). Mutations at one of 5 cysteines in the extracellular domain ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Medizinische Klinik 95 (2000), S. 503-516 
    ISSN: 1615-6722
    Keywords: Schlüsselwörter Neuroendokrinologie ; Zytokine ; Wachstumsfaktoren ; Hypophysentumoren ; Wachstumshormonsubstitution ; Key words Neuroendocrinology ; Cytokines ; Growth factors ; Pituitary tumors ; Growth hormone replacement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Background: Presentation of current data and knowledge in the field of experimental and clinical neuroendocrinology. Aim: Overview of current data on the pathogenesis and therapeutic strategies of pituitary disorders. 1. Hypothalamic and pituitary regulation: characterization of influence of hormone secretion and cell proliferation of anterior pituitary cells by an intrapituitary network of cytokines and growth factors. Special importance on the role of the interleukin-6-family. Characterization of the role of gaseous transmitters in neuroendocrinology. 2. Molecular pathogenesis of pituitary adenomas: presentation of the current knowledge status with regard to familial syndromes. 3. Therapy of pituitary adenomas: presentation of new developments of therapeutic aspects, in particular medical treatment, surgery and radiation. Outlook on the future role of gene therapy. 4. Growth hormone replacement in adults: short overview of diagnosis and therapy of growth hormone deficiency in the adult.
    Notes: Zusammenfassung Hintergrund: Darstellung der aktuellen Daten und Erkenntnisse im Bereich der experimentellen und klinischen Neuroendokrinologie. Ziel:Überblick über aktuelle Daten zu Pathogenese und therapeutischen Strategien von Hypophysenerkrankungen. 1. Hypothalamisch-hypophysäre Regulation: Charakterisierung der Beeinflussung von Hormonsekretion und Zellproliferation von Adenohypophysenzellen durch ein intrahypophysäres Netzwerk von Zytokinen und Wachstumsfaktoren. Besondere Darstellung der Bedeutung der Interleukin-6-Familie. Charakterisierung auch der Bedeutung gasförmiger Transmitter in der Neuroendokrinologie. 2. Molekulare Pathogenese von Hypophysenadenomen: Darstellung des aktuellen Kenntnisstandes, insbesondere auch unter Berücksichtigung der familiären Syndrome. 3. Therapie der Hypophysenadenome: Darstellung neuer Entwicklungen auf den therapeutischen Gebieten, insbesondere medikamentöse Therapie, operative Maßnahmen und Strahlentherapie. Ausblick auf die zukünftige Bedeutung der Gentherapie. 4. Wachstumshormonsubstitution bei Erwachsenen: kurze Übersicht zur Diagnose und Therapie des Wachstumshormonmangels beim Erwachsenen.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-6903
    Keywords: CRF ; CRF-receptor ; locus coeruleus ; catecholamines ; autonomic nervous system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Corticotropin-releasing factor (CRF) is both a major regulator of the hypothalamo-pituitary-adrenal (HPA) axis and the activity of the autonomic nervous system. Besides, it exerts numerous effects on other physiological functions such as appetite control, motor and cognitive behavior and immune function. The basis for these effects is constituted by its distribution in hypothalamic and extrahypothalamic brain areas, the latter being represented by limbic structures such as the central nucleus of the amygdala or by brain stem neurons such as the locus coeruleus (LC) or nucleus of the solitary tract (NTS). The effects of CRF are mediated through recently described CRF-receptor subtypes, whose molecular biology, biochemistry and pharmacological regulation are discussed in detail. In the second part of this review, we will focus on the physiology of CRF-systems in the brain, with a particular emphasis on cardiovascular regulation, respiration, appetite control and stress-related behavior. Finally, the role of the locus coeruleus in the control of CRF-mediated behavioral activities is discussed. The interaction of noradrenergic and CRF-neurons clearly implies that CRF appears to directly activate LC neurons in a stressful situation, thus ultimately coordinating the bodily response to a stressful stimulus.
    Type of Medium: Electronic Resource
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