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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of chlorpropamide in epileptic patients: Effects of enzyme induction and urine pH on chlorpropamide elimination (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 297-301 
    Details
    ISSN: 1432-1041
    Keywords: chlorpropamide ; epileptics ; pharmacokinetics ; antiepileptic drug ; protein binding ; antipyrine test ; urine pH ; excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of liver enzyme induction and of urine pH on the pharmacokinetics of chlorpropamide have been studied. A single oral dose of chlorpropamide 250 mg was administered to 8 patients on antiepileptic drugs (phenytoin, carbamazepine) and to 8 healthy volunteers. The half-life of chlorpropamide was significantly shorter in the patients (34.4 h) than in the healthy volunteers (50.2 h), but the difference between the groups in the half-life of antipyrine was even more pronounced (5.1 vs 11.4 h). The clearance and volume of distribution of total chlorpropamide were significantly higher in the patients (2.99 ml·h−1·kg−1 and 126 ml·kg−1) than in the healthy volunteers (1.60 ml·h−1·kg−1 and 106 ml·kg−1). The unbound fraction of chlorpropamide in serum was also higher in the patients (5.7%) than in the healthy subjects (4.4%). Neither the volume of distribution nor the clearance of the free fraction of chlorpropamide differed significantly between the groups. There was a significant correlation between the half-lifes of chlorpropamide and antipyrine, and the half-life of chlorpropamide also had at least as good an inverse correlation with the urinary excretion of unchanged chlorpropamide. The renal clearance of chlorpropamide correlated well with urine pH and was almost 100-fold higher at pH 7 than at pH 5. Both the metabolic and renal clearances of chlorpropamide are important in its elimination. At urine pH higher than 6.5–7, the renal clearance of chlorpropamide represents more than half its total clearance regardless the degree of induction of liver enzymes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607578
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  • 2
    Electronic Resource
    Electronic Resource
    Antipyretic analgesics in patients on antiepileptic drug therapy (1979)
    Springer
    European journal of clinical pharmacology 15 (1979), S. 263-268 
    Details
    ISSN: 1432-1041
    Keywords: analgesics ; carbamazepine ; phenytoin ; phenylbutazone ; acetylsalicylic acid ; drug interactions ; epileptic patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of administration for three days of acetylsalicylic acid (1500 mg/day), phenylbutazone (300 mg/day), paracetamol (1500 mg/day) and tolfenamic acid (300 mg/day) on serum concentrations of phenytoin and carbamazepine were studied in a group of patients on continuous antiepileptic therapy. When measured 10 h after the last dose of the analgesics, the only significant effect was a decrease in total serum phenytoin after three days of phenylbutazone. When six patients on continuous phenytoin therapy took phenylbutazone for two weeks there was at two days an initial decrease, followed by a significant increase in total serum phenytoin and a concomitant increase in free phenytoin in serum. Even phenylbutazone was well tolerated by most of the patients. However, its use had to be discontinued in one patients due to obvious signs of phenytoin intoxication, with concomitant increases in the serum free and total phenytoin concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00618515
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Logarithmic-normal distribution of cerebrospinal fluid folate concentrations (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 585-586 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die Folatkonzentration der Zerebrospinalflüssigkeit wurde bei 416 neurologischen Patienten mikrobiologisch bestimmt. Es wurde festgestellt, dass die Werte einer logarithmisch-normalen Verteilungskurve folgen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01896524
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of antiepileptic drugs on the elimination of various tetracycline derivatives (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 147-154 
    Details
    ISSN: 1432-1041
    Keywords: Drug interaction ; tetracyclines ; doxycycline ; anticonvulsants ; elimination ; half-life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Elimination of the bacteriostatics tetracycline, doxycycline, methacycline, oxytetracycline, demethylchlortetracycline and chlortetracycline was studied in healthy control persons and in patients on long-term antiepileptic therapy. The half-life of doxycycline was significantly shorter in patients than in the controls. The half-lives of other tetracycline derivatives and their excretion in urine were not significantly different between the two groups. Accordingly, in order to maintain an adequate serum level of doxycycline it should be given twice daily to patients on long-term therapy with barbiturates, diphenylhydantoin or carbamazepine. The classical tetracycline derivatives studied may be administered according to conventional principles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614011
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    Paper (German National Licenses)
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