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  • 1
    Electronic Resource
    Electronic Resource
    PI LBEI and PI JHOU: two new alpha-1-antitrypsin alleles (1984)
    Springer
    Human genetics 〈Berlin〉 68 (1984), S. 48-50 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two new variants of alpha-1-antitrypsin were found in a Chinese population by isoelectric focusing in polyacrylamide gel. They have been named Lbeijing (PI*LBEI) and Jhouyao (PI*JHOU) respectively. With the samples reduced and alkylated, both the variants were anodal to M1 and cathodal to L. Omitting the alkylation step, however, the relative mobilities of L and Jhouyao were altered. Under this condition, a characteristic of Jhouyao was revealed by isoelectric focusing in immobilized pH gradient 4.4–4.9, i.e., while its band 6 became anodal to L, band 4 was still cathodal to L.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293870
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Types and subtypes of haptoglobin in the Chinese population (1983)
    Springer
    Human genetics 〈Berlin〉 63 (1983), S. 175-177 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Haptoglobin phenotypes of 1121 unrelated Chinese blood donors in Beijing were determined. The gene frequency of Hp1 was 0.270. A rare variant, which we identified as Hp1S-J, was found. Two hundred and two samples of this population were submitted to haptoglobin subtyping, and no HpIF allele was found among them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291540
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Inversion and Transposition of Tc1 Transposon of C. elegans in Mammalian Cells (1998)
    Springer
    Somatic cell and molecular genetics 24 (1998), S. 363-369 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Tc1/mariner transposons are widespread in the eukaryotes. In vitro transposition test indicated that the transposase is the only protein that is needed in transpositions. It was shown later that the reconstructed Tc1-like transposon, “sleeping beauty” in fish, and the Tc1 transposon in C. elegans jumps in human cells. This discovery indicates that the Tc1/mariner transposon may be engineered as a somatic gene therapy vector if coupled with an efficient gene delivery system. We introduced the Tc1 transposon from C. elegans into different mammalian cell lines and detected the transposition events, indicating that Tc1 transposon functions in different mammalian cells. Interestingly, a high inversion frequency of the transposon was also detected, suggesting that this type of transposon may add variations to host genome when it is horizontally transferred into a new species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1024494508878
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    Paper (German National Licenses)
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