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  • 1
    Electronic Resource
    Electronic Resource
    The role of AP-1 in matrix metalloproteinase gene expression (1993)
    Springer
    Inflammation research 39 (1993), S. C215 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In an effort to understand the mechanism of matrix metalloproteinase (MMP) induction, lapine synoviocytes were isolated and incubated with phorbol myristate acetate (PMA) and autocrine “cell-activating factors” (CAF), agents which significantly increase MMP mRNA abundance. AP-1 complexes, formed by c-fos and c-jun which bind to 5′ residues of the MMP genes, seem causally related to MMP gene expression in response to PMA. However, although AP-1 DNA binding activity is strongly induced following exposure of synoviocytes to CAF, MMP gene expression in response to CAF does not correlate well with AP-1 activity and is not inhibited by antisense DNA to fos and jun. We hypothesize that there is a CAF-response factor involved in MMP gene expression and that this factor competes with the binding of the AP-1 complex to its target response element.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972770
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  • 2
    Electronic Resource
    Electronic Resource
    Dynamic MR imaging of hepatolithiasis (1998)
    Springer
    Abdominal imaging 23 (1998), S. 515-519 
    Details
    ISSN: 1432-0509
    Keywords: Key words: MR—Liver—Hepatolithiasis—Cholangitis—Contrast enhancement—Portal vein obstruction.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: To report the dynamic magnetic resonance (MR) imaging findings of hepatolithiasis. Methods: Dynamic MR images (fast spoiled gradient echo sequence with intravenous injection of gadopentate dimeglumine) and computed tomography, cholangiography, or angiography of nine patients with hepatolithiasis are analyzed. Results: All affected hepatic segments showed atrophic changes and contained dilated intrahepatic ducts. These segments showed either iso- or hypointensity on T1-weighted imaging and hyperintensity on T2-weighted imaging. Preferential enhancement was noted throughout all phases of the dynamic study and persisted to delayed T1-weighted imaging in seven patients. In the last two patients, severe atrophic changes made evaluating signal intensity differences and enhancement patterns difficult. Conclusion: In addition to intrahepatic stones and biliary dilatation, segmental atrophy, signal intensity differences, and preferential and persistent enhancement are important MR findings of hepatolithiasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900390
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  • 3
    Electronic Resource
    Electronic Resource
    A parallel algorithm for estimating the secondary structure in ribonucleic acids (1990)
    Springer
    Biological cybernetics 63 (1990), S. 337-340 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract A parallel algorithm for estimating the secondary structure of an RNA molecule is presented in this paper. The mathematical problem to compute an optimal folding based on free-energy minimization is mapped onto a graph planarization problem. In the planarization problem we want to maximize the number of edges in a plane with no two edges crossing each other. To solve a sequence of n bases, n(n — 1)/2 processing elements are used in our algorithm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202750
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  • 4
    Electronic Resource
    Electronic Resource
    Optimization of the Viability of Probiotics in a New Fermented Milk Drink by the Genetic Algorithms for Response Surface Modeling (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 68 (2003), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: : Calcium gluconate (0.0 to 0.5%), sodium gluconate (0.0 to 1.0%), and N-acetylglucosamine (0.0 to 1.0%) were added to skim milk to retain the viability of Lactobacillus acidophilus and Bifidobacterium longum. To carry out response surface modeling, the regression method was performed on experimental results to build mathematical models. The models were then formulated as an objective function in an optimization problem that was consequently optimized using a genetic algorithm approach to obtain the maximum viability of the probiotics. The genetic algorithms (GAs) were examined to search for the optimal value. The results indicated that GAs were very effective for optimizing the activity of probiotic cultures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2003.tb05722.x
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  • 5
    Electronic Resource
    Electronic Resource
    Factors Affecting the Water-Holding Capacity of Fibrinogen/Plasma Protein Gels Optimized by Response Surface Methodology (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 67 (2002), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: : Response surface methodology (RSM) was applied to optimize the water-holding capacity (WHC) of fibrinogen/plasma protein gels heated at 75°C for 10 min to develop a new edible gel. The effects of varying the amount of fibrinogen, plasma protein, calcium, and pH were evaluated to optimize the WHC using RSM. Estimation of the overall effects of the 4 factors on the gels revealed that the pH and concentrations of fibrinogen and plasma protein significantly affected the WHC of the gels (p 〈 0.05). The WHC increases with the concentrations of plasma protein only at concentrations lower than 8%. At lower plasma concentrations, fibrinogen addition had only minimal influence on the WHC. The optimum WHC values were predicted by the RSREG procedure of the SAS program. Model verification was performed by additional independent trials, and the resulting experimental values were very close to the predicted ones with no significant difference (p 〉 0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2002.tb08780.x
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  • 6
    Electronic Resource
    Electronic Resource
    Characterization of Polysaccharide and Volatile Compounds Produced by Kefir Grains Grown in Soymilk (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 67 (2002), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: : The characteristics of polysaccharides isolated from milk and soymilk kefir grains, and the composition of flavor and volatile compounds from soymilk kefir were investigated. Soymilk kefir grains revealed lower polysaccharide content than milk kefir grains, with a polysaccharide profile consisting primarily of glucose and galactose, with the former predominating. The apparent molecular weight of the polysaccharide was estimated at 1.7 × 106 Da. In comparison to nonfermented soymilk, the concentrations of the key volatile compounds for soymilk kefir (such as acetaldehyde, acetone, diacetyl, and ethanol) increased, while n-hexanal concentration decreased. The acetaldehyde level for soymilk kefir was slightly higher, but levels for the other volatile compounds were lower than for milk kefir.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2002.tb11367.x
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  • 7
    Electronic Resource
    Electronic Resource
    Synthesis and biological activity of CCK heptapeptide analogs. Effects of conformational constraints and standard modifications on receptor subtype selectivity, functional activity in vitro, and appetite suppression in vivo (1992)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 35 (1992), S. 2919-2928 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00094a001
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  • 8
    Electronic Resource
    Electronic Resource
    Properties of plasma-enhanced chemical-vapor-deposited a-SiNx:H by various dilution gases (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 3645-3655 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effects of dilution gases on hydrogenated amorphous silicon nitride (a-SiNx:H) films were investigated. Silane and ammonia were used as the reactive species, while nitrogen, helium, hydrogen, and argon were used as the dilution gases in a plasma-enhanced chemical vapor-deposition system at a substrate temperature of 300 °C. The electrical, physical, and chemical properties of the a-SiNx:H films were found to be highly sensitive to the various kinds and flow rates of the carrier gases in the deposition. Additionally, the physical properties of growth rate, refractive index, and etching rate were also investigated. The hydrogen bonding configuration was explored by infrared spectroscopy. The total hydrogen concentrations for all a-SiNx:H films were observed to be smaller than 3.0×1022 cm−3. The electrical properties were characterized by I-V and C-V measurements in metal-insulator-semiconductor structures. The breakdown strength was determined at the current density of 3 mA/cm2; in addition, the dominant mode of electronic conduction would appear to be the Poole–Frenkel emission. The interface trap state density Dit which ranged from 3.4×1011 to 1.3×1012 cm−2 eV−1 was evaluated by the C-V characteristics. Finally, the influences of the gas dilution in the a-SiNx:H films, as applied to the devices, were investigated by using the hydrogenated amorphous silicon thin-film transistors (a-Si:H TFTs). Analyses of the transfer characteristics of the TFT devices revealed that the density of deep gap states is 4×1012 cm−2 eV−1 and the field-effect mobility μFE is changing from 0.37 to 1.45 cm2/V s.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.357428
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  • 9
    Electronic Resource
    Electronic Resource
    Biochemical characterization of crystallins from pigeon lenses: structural and sequence analysis of pigeon δ-crystallin
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 1160 (1992), S. 317-324 
    Details
    ISSN: 0167-4838
    Keywords: (C. livia) ; Argininosuccinate lyase ; Glycogen ; Pigeon lens ; Polymerase chain reaction ; Sequence comparison ; δ-Crystallin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4838(92)90094-T
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  • 10
    Electronic Resource
    Electronic Resource
    Sequence analysis of pigeon δ-crystallin gene and its deduced primary structure Comparison of avian δ-crystallins with and without endogenous argininosuccinate lyase activity
    Amsterdam : Elsevier
    FEBS Letters 311 (1992), S. 276-280 
    Details
    ISSN: 0014-5793
    Keywords: Argininosuccinate lyase ; Columba livia ; Pigeon ; Pigeon lens ; Polymerase chain reaction (PCR) ; Sequence comparison ; δ-Crystallin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(92)81119-7
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