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  • 1
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 575-578 (Apr. 2008), p. 811-815 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Linear friction welding (LFW) has become a key manufacture and repair technology in theaeronautical engine manufacturing, especially in the blisk manufacturing. The kinematic equationduring LFW was built, based on which the friction heat in the whole process was computed. Withthermal- mechanical coupling technique, and considering the geometrical non-linearity, the materialproperty non-linearity and the interface frictional non-linearity, a Finite Element Model (FEM) oftemperature, stress and deformation fields were constructed. The distribution contour of temperature,plastic flow, stress and strain during LFW were plotted. The simulated temperature and axialshortening results were also validated by experimental data
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 2 (1993), S. 0 
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Using ihe indirect immunohistochemical approach, the occurrence of γ-melanocyte stimulating hormone (γ-MSH)-like immunoreactivily in human normal keratinocytes is described. The positive cells were observed in each layer of the epidermis (except stratum corneum) and often, at the level of the stratum spinosum, also around the orifices of cutaneous accessory organs, such as sweat glands and sebaceous glands/ hair follicles. Combining these data with our previous investigations, the results support the possibility that locally produced γ-MSH could be involved in cutaneous immune response, pigmentation and epithelial pro-liferation, as well as neuromodulation.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 5126-5138 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 93 (2005), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The deactivation of visual pigments involved in phototransduction is critical for recovering sensitivity after exposure to light in rods and cones of the vertebrate retina. In rods, phosphorylation of rhodopsin by rhodopsin kinase (GRK1) and the subsequent binding of visual arrestin completely terminates phototransduction. Although signal termination in cones is predicted to occur via a similar mechanism as in rods, there may be differences due to the expression of related but distinct gene products. While rods only express GRK1, cones in some species express only GRK1 or GRK7 and others express both GRKs. In the mouse, cone opsin is phosphorylated by GRK1, but this has not been demonstrated in mammals that express GRK7 in cones. We compared cone opsin phosphorylation in intact retinas from the 13-lined ground squirrel (GS) and pig, cone- and rod-dominant mammals, respectively, which both express GRK7. M opsin phosphorylation increased during continuous exposure to light, then declined between 3 and 6 min. In contrast, rhodopsin phosphorylation continued to increase during this time period. In GS retina homogenates, anti-GS GRK7 antibody blocked M opsin phosphorylation by 73%. In pig retina homogenates, only 20% inhibition was observed, possibly due to phosphorylation by GRK1 released from rods during homogenization. Our results suggest that GRK7 phosphorylates M opsin in both of these mammals. Using an in vitro GTPγS binding assay, we also found that the ability of recombinant M opsin to activate Gt was greatly reduced by phosphorylation. Therefore, phosphorylation may participate directly in the termination of phototransduction in cones by decreasing the activity of M opsin.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 1837-1839 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: This article reports on a new apparatus, called the laser double ablation reactor, for studies on the reactivity of clusters. Structure and operative principle of the apparatus were presented. With this apparatus reactions between manganese/carbon clusters and sulfur clusters, and between silver and sulfur clusters were studied. The experiments indicate that manganese/carbon clusters appear inert when they react with sulfur clusters, while for reactions between silver and sulfur clusters, the products [AgS4]+, [AgS8]+, [AgS12]+, and [AgS16]+, mainly are obtained. In comparison to the results obtained by Fourier transform ion cyclotron resonance, it shows that the new apparatus is very efficient for study on reactions between clusters. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Considerable controversy has surrounded the question of possible biological responses to electromagnetic fields (EMFs) generated from visual display terminals (VDTs), such as personal computers (PCs) and ordinary television sets (TVs). The cellular and molecular mechanisms for such potential harmful health hazards have not yet been understood, although clues from the literature include mast cells and histamine. The aim of this study was therefore to investigate possible biological mast cell responses to TV/PC screens.Methods: Using the indirect immunofluorescence technique, we studied the presence of histamine-containing mast cells in the dermis of healthy volunteers. Cutaneous biopsies taken before and after exposure to ordinary TV/PC screens for 2 or 4 h were investigated in 13 healthy subjects.Results: Our present in vivo study indicates that normal cutaneous mast cells could be altered by exposure from ordinary TV/PC screens. To our great surprise, we found the number of mast cells in the papillary and reticular dermis to increase, to varying degrees, in 5 out the 13 subjects after such an exposure. A migration of mast cells towards the uppermost dermis appeared as the most important event. Thus, the normally upper “empty zone” of the dermis disappeared, and instead, a higher density of mast cells were found in this zone. These cells also seemed to have a tendency to increase in number towards the epidermal-dermal junctional zone and some of them lost their granular content and the cytoplasm shrunk (=degranulation). These findings could only be seen in the exposed skin. Two of the 13 cases instead showed a decrease in mast cell number, but the shift in mast cells towards the upper dermis was still visible. Twenty-four h after the provocation, the cellular number and location were normalized in all subjects.Conclusions: By definition, normal healthy volunteers are assumed not to react to a TV/PC screen provocation. To our great surprise, this proved not to be true. The present results might lay a foundation to understand the underlying cause of so-called “screen dermatitis” with special reference to mast cells. However, blind or double-blind experiments using patients ought to be further investigated in order to find out the exact cause for the observed changes. Such causes include the effects of surrounding airborne chemicals, stress factors, etc.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Human and mouse genetic and in vitro evidence has shown that canonical Wnt signaling promotes bone formation, but we found that mice lacking the canonical Wnt antagonist Dickkopf2 (Dkk2) were osteopenic. We reaffirmed the finding that canonical Wnt signaling stimulates osteogenesis, including the ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 288 (1996), S. 670-675 
    ISSN: 1432-069X
    Keywords: Key words Neuropeptide ; Neuronal structural marker ; Immunohistochemistry ; Human skin ; Melanocyte ; destruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pioneering studies both in humans and animals have demonstrated an association between the peripheral nervous system and epidermal melanocyte destruction. The presence of certain neuropeptides and neuronal structural markers in peripheral nerve fibres was investigated in involved and uninvolved vitiligo skin and compared with normal healthy skin. A group of 18 vitiligo vulgaris patients and matched healthy volunteers participated in the investigation. The indirect immunofluorescence technique was employed. There was a tendency for a reduction in the number and intensity of low affinity (p75) nerve growth factor receptor immunoreactive (NGFr-IR) basal keratinocytes in involved vitiliginous skin ( P 〈 0.06) compared with control skin, while the number of NGFr-IR nerve fibres was significantly increased ( P 〈 0.01). The number of calcitonin gene-related peptide (CGRP)-IR nerve fibres in the epidermis and papillary dermis was dramatically increased in involved skin as compared with control skin ( P 〈 0.01) and with uninvolved skin ( P 〈 0.05). No clear difference could be found in the distribution of vasoactive intestinal polypeptide (VIP)- and neuropeptide tyrosine (NPY)-IR nerve fibres. A different structural appearance of the peripheral nervous system as well as a changed balance of neuropeptides in vitiliginous skin point to a critical role of the nervous system in the pathogenesis of vitiligo.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of low temperature physics 92 (1993), S. 181-187 
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Tensile tests show that ferroelastic loops always occur at 100–150 K, 200–250 K and room temperature in the Y1−xPrxBa2Cu3Oy samples withx=0 and 0.1 for whichT c is 92 K and 82.5 K respectively, and the shape memory effect is always observed in the compact sample near 130 K, just similar to that of thermal elastic martensitic alloys. The loss fraction (ΔW/W) which is proportional to the area of ferroelastic loop as a function of temperature shows that there always exist static hysteresis (ΔW/W) peaks at 130 K and 110 K which are attributed to the phaselike transition (PLT) characterized by the jump of lattice parameters. No ferroelastic loops and shape memory effect are observed in the range of 100 K to 150 K for the lowerT c samples withx=0.3, 0.4 and 0.6.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Distributed and parallel databases 8 (2000), S. 7-40 
    ISSN: 1573-7578
    Keywords: information warfare ; trusted recovery ; databases ; security ; malicious transactions ; transaction histories
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract We consider recovery from malicious but committed transactions. Traditional recovery mechanisms do not address this problem, except for complete rollbacks, which undo the work of good transactions as well as malicious ones, and compensating transactions, whose utility depends on application semantics. We develop an algorithm that rewrites execution histories for the purpose of backing out malicious transactions. Good transactions that are affected, directly or indirectly, by malicious transactions complicate the process of backing out undesirable transactions. We show that the prefix of a rewritten history produced by the algorithm serializes exactly the set of unaffected good transactions. The suffix of the rewritten history includes special state information to describe affected good transactions as well as malicious transactions. We describe techniques that can extract additional good transactions from this latter part of a rewritten history. The latter processing saves more good transactions than is possible with a dependency-graph based approach to recovery.
    Type of Medium: Electronic Resource
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