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  • 1
    Electronic Resource
    Electronic Resource
    Human T-Lymphocyte Subpopulations: Alterations in Systemic Lupus Erythematosus (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 10 (1979), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sharply reduced proportions of T cells with Fc receptors for IgG (TG cells) were observed in blood samples from patients with systemic lupus erythematosus (SLE), mainly with active disease. This T-cell subset has previously heen shown to be a suppressor in the pokeweed mitogen (PWM)-dependent B-cell differentiation. In contrast, the percentages of T cells with Fc receptors for IgM (TM cells), which have been shown to help inimunoglobulin production, were not different from those of normals. TG cells present in the circulation of SLE patients were analysed for their functional capacities in antibody-dependent cell-mediated cytotoxicity and in the suppression of a PWM-induced B-cell differentiation. In both these assays TG cells from SLE patients had normal effector cell activity. This suggests that the T-cell defects present in SLE patients are mainly of a quantitative rather than a qualitative type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1979.tb01343.x
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  • 2
    Electronic Resource
    Electronic Resource
    Fc Receptors on Human T Lymphocytes: Loss of Fcμ and Expression of Fcγ Receptors by T Cells Stimulated in Mixed Lymphocyte Reaction (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 13 (1981), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The consequences of allogeneic stimulation on the expression of Feμ or Feγ receptors were analysed in T-cell populations responding in mixed lymphocyte reaction (MLR). Unfractionated T-cell populations were cultured with a pool of irradiated allogeneic T-depleted cells. The responder E -rosetting cells progressively lost Feμ and acquired Fcγ receptors. The change of the original Fc receptor phenotype is not the consequence of a preferential proliferative response of TG versus TM cells but is likely due to a de novo expression of Feγ receptors by T cells lacking detectable Fc receptors (T-null) and also to the loss of Fcμ and expression of Feγ receptors by TM cells. These data suggest that, after MLR, responder T cells can modify their Fc receptor phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1981.tb00155.x
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  • 3
    Electronic Resource
    Electronic Resource
    Suppressor Activity of T Cells Bearing Fc Receptors for IgG on Lymphoid Colony Formation (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 12 (1980), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Human T lymphocytes, upon phytohaemagglutinin stimulation, are able to form colonies in semisolid media. Peripheral T cells bearing Fc receptors (TG) were studied for their possible regulatory activity on lymphoid colony development. Although no substantial differences were observed between the cloning efficiency of unfractionated T cells (thus including TG cells) and T cells depleted of TG, a sharp suppression of colony formation occurred when positively selected TG cells were readded to TG-depleted suspensions. Therefore, TG suppressor activity seems to be strictly dependent upon cell interaction with ox IgG immune complexes used for TG cell isolation. Different experimental approaches failed to demonstrate, although did not exclude, that suppression in this system is mediated by soluble factors, γ-irradiation of TG cells abrogated their suppressor capacity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1980.tb00099.x
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  • 4
    Electronic Resource
    Electronic Resource
    Natural Killer Cells: A Mystery No More (2002)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 55 (2002), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recent years have witnessed remarkable progress in our understanding of the molecular mechanism regulating natural killer (NK) cell function. NK cells can sense whether cells have lost the surface expression of major histocompatibility complex (MHC)-class I molecules. The discovery of MHC-class I-specific inhibitory receptors clarified the basis of this discrimination and elucidated the nature of the ‘off’ signal. However, the receptors responsible for the ‘on’ signal in the process of natural cytotoxicity remained mysterious until recently. Here, we describe the identification and characterization of such receptors and discuss the emerging implications of these findings in different diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2002.01055.x
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  • 5
    Electronic Resource
    Electronic Resource
    Human interleukin-2 promotes proliferation of activated B cells via surface receptors similar to those of activated T cells (1984)
    [s.l.] : Nature Publishing Group
    Nature 312 (1984), S. 641-643 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. I B-cell growth factor activity of human IL-2. BCGF activity was measured using the assay system described by Muraguchi and Fauci9, with minor modifications10. This system is based on cultur-ing B cells for 72 h with formaldehyde-killed S. aureus Cowan strain I before addition of tested growth ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/312641a0
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    Paper (German National Licenses)
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