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  • 1
    Electronic Resource
    Electronic Resource
    Prophylactic versus on-demand treatment strategies for severe haemophilia: a comparison of costs and long-term outcome (2002)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 8 (2002), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  A multicentre study was performed to compare clotting factor use and outcome between on-demand and prophylactic treatment strategies for patients with severe haemophilia. Data on treatment and outcome of 49 Dutch patients with severe haemophilia, born 1970–80, primarily treated with prophylaxis, were compared with those of 106 French patients, who were primarily treated on demand. Dutch patients received intermediate dose prophylaxis, for a median duration of 12.7 years. Patients primarily treated with prophylaxis had fewer joint bleeds per year (median 2.8 vs. 11.5), a higher proportion of patients without joint bleeds (29% vs. 9%), lower clinical scores (median 2.0 vs. 8.0), and less arthropathy as measured by the Pettersson score (median 7 points vs. 16 points). Mean annual clotting factor use was equal at 1488 ± 783 IU kg−1 year−1 (mean ± standard deviation) for patients primarily treated with prophylaxis and 1612 ± 1442 IU kg−1 year−1 for patients primarily treated on demand. These findings suggest that, compared with a primarily on-demand treatment strategy, a primarily prophylactic treatment strategy leads to better outcome at equal treatment costs in young adults with severe haemophilia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.2002.00695.x
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of the impact of information about treatment-related risks in patients receiving blood-derived or recombinant medications (2004)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 10 (2004), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  The aims of the study were to evaluate the impact of a written information about treatment related risks in patient receiving blood derived or recombinant medications. Haemophiliac patients and patients with constitutional or acquired immune deficiencies are concerned by this treatment and these information. Our objectives are to evaluate the efficacy of the written information, the knowledge of the patients about these medications and the psychological, emotional impact if these information. The study is based on questionnaires which specified how the patient treat bleeding episodes, their knowledge about viral safety of blood products, the patient's perception of his or her health status and relationship with the physician. Psychological and emotional status are evaluated with the Hospital Anxiety and Depression Scale. The results show the difficulty to inform patients: if the information generate only limited anxiety in patients with haemophilia or immune deficiencies, we observe that the delivery of a written information got a mediocre effect on overall knowledge. We think that this information must be appropriate for patients and be communicated orally within the patient–physician relationship.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.2004.00930.x
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  • 3
    Electronic Resource
    Electronic Resource
    A retrospective study on chemical and radioactive synovectomy in severe haemophilia patients with recurrent haemarthrosis (1999)
    Oxford UK : Blackwell Science Ltd
    Haemophilia 5 (1999), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Between 1970 and 1994, 116 chemical and 90 radioactive synovectomies were performed in 107 patients with severe haemophilia and two with type 3 von Willebrand's disease. The products used were osmic acid (OA) in 100 cases, 90-Yttrium in 35 cases, 186-Rhenium in 48, 169-Erbium in two, hexacetonide triamcinolone in 16 and radioactive gold in five cases. The use of radioactive colloids is not allowed in France in patients under 15 years of age. Twenty-nine patients had more than one synovectomy per joint. All patients were evaluated for 6 months post-synovectomy, using both a clinical and a radiological score. Six months after synovectomy, a good or excellent result was obtained for 81% of the joints treated with isotopes, compared with 44% of those treated with OA, P 〈 0.001. This superiority of isotopes over osmic acid was still observed after 6 months for the 89 joints that were re-evaluated, with follow-up ranging from 1 to 9 years. It was possible to calculate a radiological score in 84 cases. With OA the best results were from the joints with the lowest scores pre-synovectomy (〈7). No correlation could be established between the clinical and the radiological scores, due to the small size of the sample. In summary: (1) chemical and radioactive synovectomy are simple and safe procedures for haemophilic arthropathy, (2) in our series, after 6 months the efficacy of isotopic synovectomy was greater than that of chemical synovectomy, and this benefit seems to persist after 6 months, and up to 9 years in the group of patients with longer-term follow-up.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.1999.00287.x
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  • 4
    Electronic Resource
    Electronic Resource
    Nonviolent (empathic) communication for health care providers (1998)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 4 (1998), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. The purpose of Nonviolent or Empathic Communication Training is to facilitate the flow of information necessary for people to work cooperatively and resolve differences effectively. Such training is widely used in medical communities where the communication with patients and the cooperation between team members are of critical importance for the effectiveness of the treatment. Communication skills are of particular importance for health care providers dealing with patients having chronic diseases such as haemophilia. In addition to the difficulties inherent to the chronicity of the disease, the HIV contamination has dramatically impaired the relationships between patients and health care providers, creating a lot of pain, still alive in both parties. The purpose of this presentation is to offer to health care providers and patients some tools to deal with their feelings and restore effective, compassionate and fulfilling communication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.1998.440335.x
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  • 5
    Electronic Resource
    Electronic Resource
    Irreversible evolution in the topology of magnetic domains (invited) (1987)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 61 (1987), S. 4188-4193 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Hysteresis does not vanish in materials essentially free from defects and domain wall pinning. It arises from the existence of many geometrically different domain structures separated by intrinsic energy barriers. Although generally metastable, these states can nevertheless be explored by suitable excursion in the manifold of domain structures, along which irreducible irreversibility is present. This idea is illustrated by experiments performed on garnet layers with uniaxial anisotropy (bubble material). Cooling the layer from T〉Tc in a field H normal to it results in various states: parallel stripes (H=0), bubbles of increasing diameters and mixtures of bubbles and stripes (H〈52 Oe), and mazes of convoluted stripes with defects (forks, dead ends). Cycling the applied field at constant temperature also causes evolution of the structure. For example, starting from parallel stripes the structure evolves toward a maze with intermediate steps corresponding to stripe folding, and then there is the onset of defects (forks, dead ends). We classify these various structures in a kind of phase diagram, depending on the following parameters: current field H, maximum field Hmax previously applied, and memory temperature Tm at which the domain structure is nucleated. The relations and irreversible paths between various structures are precised. We also discuss mechanisms for topological evolution linked with changes in the equlibrium period of the structure. Irreversibility arises from asymmetric processes of domain collapse and nucleation. The first stages in the processes leading from bubbles to stripes, or from parallel stripes to mazes, can be analyzed respectively in terms of elliptical and folding instabilities, the latter being similar to the undulation instability of smectic A liquid crystals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.338473
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  • 6
    Electronic Resource
    Electronic Resource
    Period competition in a stripe domain structure subjected to a periodic field (1988)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 63 (1988), S. 4327-4329 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The behavior of a parallel array of stripe domains subjected to a periodic field was studied. Experiments were performed on a layer of single-crystal ferrimagnetic garnet (bubble material) featuring in zero field a periodic pattern of parallel stripe domains. The layer was applied to a magnetic tape on which a sinusoidal waveform was recorded. The garnet-tape distance, and hence the interaction strength, could be varied. The resulting domain patterns were observed in polarized light. We present results obtained for a recorded wavelength (66 μm) equal to six times the natural domain period (11 μm). The domain structure adapted itself by reducing the number of stripes, in particular by means of dislocation glide in the stripe array. This resulted in various modulated stripe patterns. The transitions between structures with different stripe numbers could be observed. These were achieved by local distortions of the parallel array around dislocations. The total energy of the garnet layer was calculated as the sum of magnetostatic, wall, and interaction energies for various interaction strengths. The equilibrium domain configuration could be deduced by minimizing the energy with respect to wall positions. The calculated modulated domain structures are in agreement with the observed one.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.340190
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  • 7
    Electronic Resource
    Electronic Resource
    Binding and endocytosis of heparin by human endothelial cells in culture
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 845 (1985), S. 196-203 
    Details
    ISSN: 0167-4889
    Keywords: (Human endothelial cell) ; Endocytosis ; Heparin binding
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4889(85)90177-6
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  • 8
    Electronic Resource
    Electronic Resource
    Modulation of endothelial cells growth induced by heparin
    Amsterdam : Elsevier
    Cell Biology International Reports 10 (1986), S. 437-446 
    Details
    ISSN: 0309-1651
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0309-1651(86)90039-1
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    ''Thermal spontaneous magnetization'' in Y"2Ni"7: A misinterpretation
    Amsterdam : Elsevier
    Journal of Magnetism and Magnetic Materials 84 (1990), S. L1-L4 
    Details
    ISSN: 0304-8853
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-8853(90)90154-I
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  • 10
    Electronic Resource
    Electronic Resource
    Evolution of the domain-like pattern in a film of ferrofluid in normal fields
    Amsterdam : Elsevier
    Journal of Magnetism and Magnetic Materials 113 (1992), S. 127-131 
    Details
    ISSN: 0304-8853
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0304-8853(92)91257-T
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