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  • 1
    Electronic Resource
    Electronic Resource
    Genetic mapping of 14 short tandem repeat polymorphisms on human chromosome 22 (1994)
    Springer
    Human genetics 〈Berlin〉 93 (1994), S. 688-690 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have constructed a linkage map of 14 short tandem repeat polymorphisms (11 with heterozygosity 〉 70%) on the long arm of human chromosome 22 using 23 non-CEPH pedigrees. Twelve of the markers could be positioned uniquely with a likelihood of at least 1,000:1, and distributed at an average distance of 6.62 cM (range 1.5–16.1 cM). The sex-combined map covers a total of 79.6 cM, the female map 93.2 cM and the male map 64.6 cM. Based on comparisons between physical maps and other genetic maps, we estimate that our map covers 70%–80% of the chromosome. The map integrates markers from previous genetic maps and uniquely positions one marker (D22S307). Data from physical mapping on the location of four genetic markers correlates well with our linkage map, and provides information on an additional marker (D22S315). This map will facilitate high resolution mapping of additional polymorphic loci and disease genes on chromosome 22, and act as a reference for building and verifying physical maps.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201571
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    ADH and ALDH genotype profiles in Caucasians with alcohol-related problems and controls (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction 88 (1993), S. 0 
    Details
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Eighty-two Caucasian patients receiving treatment for alcohol-related problems and eighty four controls were DNA typed for variants in the alcohol dehydrogenase (ADH2 and ADH3) and mitochondrial aldehyde dehydrogenase (ALDHJ gene loci. No association was observed between individual, or combined gene frequencies and the presence of alcohol-related problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1360-0443.1993.tb00825.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Prenatal exposure to influenza epidemics and risk of mental retardation (1995)
    Springer
    European archives of psychiatry and clinical neuroscience 245 (1995), S. 255-259 
    Details
    ISSN: 1433-8491
    Keywords: Mental retardation ; Influenza ; Mid-pregnancy ; Schizophrenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was undertaken to determine whether prenatal exposure to influenza epidemics increases the risk of mental handicap. The monthly birth frequencies of 827 first-admission individuals (mean age at admission 13 years) with a primary diagnosis of non-specific mental retardation, discharged from psychiatric hospitals in England and Wales, were examined in relation to the monthly death rates from influenza over the period 1953–1980. The relative risk of developing mental handicap when exposed to influenza epidemics during mid-gestation was assessed by a generalized linear model. Increased death rates from influenza, a measure of prevalence of the infection, were significantly associated with an increase in births of mentally handicapped individuals 6 months later. For every 1000 female deaths from influenza there was a 17% increase in births of mentally handicapped individuals 6 months later. Maternal exposure to influenza at approximately the third to fourth month of gestation may be risk factor for developing mental handicap.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02191805
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Do noradrenergic reuptake inhibitors affect serotonergic function in depression? (1997)
    Springer
    Psychopharmacology 134 (1997), S. 406-410 
    Details
    ISSN: 1432-2072
    Keywords: Key words Major depression ; d-Fenfluramine ; Serotonin ; Cortisol ; Prolactin ; Noradrenaline ; Antidepressants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract   d-Fenfluramine, a specific 5-HT releasing agent without the catecholamine effects of d,l-fenfluramine, was used as a serotonergic neuroendocrine challenge in subjects with unipolar major depression. Prolactin and cortisol responses to 30 mg d-fenfluramine were measured in patients at baseline. Patients were then randomly assigned to treatment for 6 weeks with a specific noradrenergic reuptake inhibitor, a tricyclic antidepressant, or placebo. Response to antidepressant treatment was assessed, and patients underwent further testing with d-fenfluramine. Prolactin responses were increased by treatment, but this was independent of whether or not patients’ depression responded to treatment. Seven patients were treated with a specific noradrenergic reuptake inhibitor. These patients showed a significant rise in 5-HT-mediated cortisol responses after treatment, independent of whether their depression improved. We conclude that antidepressants which selectively modify noradrenergic function also have effects on 5-HT function as measured by neuroendocrine testing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050478
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Factors affecting the urinary excretion of endogenously formed dimethyltryptamine in normal human subjects (1977)
    Springer
    Psychopharmacology 54 (1977), S. 171-175 
    Details
    ISSN: 1432-2072
    Keywords: Dimethyltryptamine ; Monomethyltryptamine ; Urinary excretion of methylated indoles ; Mass fragmentography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The hallucinogenic substance N′,N′-dimethyltryptamine and its precursor N-methyltryptamine were found in 24-h speciments of urine from 19 normal human subjects; the mean excretion rates were 386 ng 24 h-1 and 856 ng 24 h-1 respectively. The urinary excretion of both compounds was unrelated to age, sex, urinary volume, or creatinine, nor was any consistent diurnal pattern observed. Rates for the mono and dimethylated compounds were not correlated. Diet and the intestinal flora were excluded as a source of urinary dimethyltryptamine. Administration to 4 subjects of sufficient ammonium chloride to increase the H ion concentration of the urine caused a transient increase in dimethyltryptamine excretion but no consistent increase in the rate for N-methyltryptamine. Acidification of the urine did not appear to be the determining factor in this result since in one subject the same drop in urinary pH was achieved by feeding methionine without any increase in dimethyltryptamine axcretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426775
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Medical adrenalectomy in patients with advanced breast cancer resistant to anti-oestrogen treatment (1981)
    Springer
    Breast cancer research and treatment 1 (1981), S. 91-95 
    Details
    ISSN: 1573-7217
    Keywords: adrenalectomy ; aminoglutethimide ; breast cancer tamoxifen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fifty-three women with actively progressing advanced breast cancer, who had all previously received tamoxifen, were treated with aminoglutethimide to induce medical adrenalectomy. Sixty-nine percent of the patients who had previously responded to tamoxifen subsequently responded to aminoglutethimide, while thirty-five percent of the nonresponders to tamoxifen subsequently responded to aminoglutethimide. The median duration of remission to aminoglutethimide was 12 months with a range from 4 to 22 + months. The drug was well tolerated and would appear to be the treatment of choice in tamoxifen responsive cases of advanced breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01805860
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    Paper (German National Licenses)
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