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  • 1
    Electronic Resource
    Electronic Resource
    Mast cell growth factor (C-Kit Ligand) in combination with granulocyte-macrophage colony-stimulating factor and interleukin-3:in vivo hemopoietic effects in irradiated mice compared toin vitro effects (1993)
    Springer
    Biotherapy 7 (1993), S. 13-26 
    Details
    ISSN: 1573-8280
    Keywords: C-kit Ligand ; GM-CSF ; Hemopoiesis ; IL-3 ; MGF ; Myelosuppression ; Radiation ; SCF
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the presence of hemopoietic cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3), mast cell growth factor (MGF; also known as steel factor, stem cell factor, and c-kit ligand) has proven to be a potent hemopoietic regulatorin vitro. In these studies, we examined thein vivo effects of MGF in combination with GM-CSF or GM-CSF plus IL-3. Effects were based on the ability of these cytokines to stimulate recovery from radiation-induced hemopoietic aplasia. Female B6D2F1 mice were exposed to a sublethal 7.75-Gy dose of60Co radiation followed by subcutaneous administration of either saline, recombinant murine (rm) MGF (100Μg/kg/day), rmGM-CSF (100Μg/kg/day), rmIL-3 (100Μg/kg/day), or combinations of these cytokines on days 1–17 postirradiation. Recoveries of bone marrow and splenic spleen colony-forming units (CFU-s), granulocyte macrophage colony-forming cells (GM-CFC), and peripheral white blood cells (WBC), red blood cells (RBC) and platelets (PLT) were determined on days 14 and 17 during the postirradiation recovery period. MGF administered in combination with GM-CSF or in combination with GM-CSF plus IL-3 either produced no greater response than GM-CSF alone or down-regulated the GM-CSF-induced recovery. These results sharply contrasted results ofin vitro studies evaluating the effects of these cytokines on induction of GM-CFC colony formation from bone marrow cells obtained from normal or irradiated B6D2F1 mice, in which MGF synergized with GM-CSF or GM-CSF plus IL-3 to increase both GM-CFC colony numbers and colony size. These studies demonstrate a dichotomy between MGF-induced effectsin vivo andin vitro and emphasize that caution should be taken in attempting to predict cytokine interactionsin vivo in hemopoietically injured animals based onin vitro cytokine effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01878150
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  • 2
    Electronic Resource
    Electronic Resource
    Utility of interleukin-1 in therapy of radiation injury as studied in small and large animal models (1989)
    Springer
    Biotherapy 1 (1989), S. 301-311 
    Details
    ISSN: 1573-8280
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary and conclusions Our results demonstrate that IL-1 promotes hematopoiesis in normal and radiation compromised animals. IL-1 protected mice from lethal hematopoietic syndrome when given before irradiation. Given after irradiation, IL-1 promoted recovery of mice and primates from radiation injury. A comparison of the effects of IL-1 in three different species indicated that hematopoiesis of mice, monkeys,and dogs is upregulated in a similar fashion by IL-1. These three species, however, vary greatly in their sensitivity to IL-1. Whereas mice and dogs tolerated doses greater than 1000 ⧎g/Kg of IL-1, 10 ⧎g/Kg of IL-1 in rhesus monkeys resulted in considerable toxic effects. Several activities of IL-1 may explain its bone marrow restorative properties. The induction with IL-1 of several hematopoietic growth factors: GM-CSF, G-CSF, M-CSF, IL 3, and IL 6, clearly contributes to the accelerated growth and differentiation of hematopoietic progenitor cells. The induction of scavenger proteins may serve to reduce post irradiation oxidative damage. Our work raised a number of additional questions concerning the potential therapeutic utility of IL-1. The ability of IL-1 to promote engraftment of allogeneic bone marrow cells will require further study. The optimal dosage, schedule, and route for IL-1 induction of hematopoiesis will need to be established. The observed synergy of IL-1 with TNF, IL 6, or CSF's may be useful in reducing the requisite doses of cytokines from pharmacological to physiological levels with concomitant reduction in toxic effects. The choice of proper cytokine combinations, however, may also be dependent on the clinical status of the patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02171006
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  • 3
    Electronic Resource
    Electronic Resource
    Hemopoiesis in pregnant beagles following low-dose total-body irradiation and surgery (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 864-866 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Hemopoietic perturbations were observed in gravid beagles subjected to whole-body ionizing radiation during midpregnancy followed by the additional trauma of surgery, with alterations in peripheral blood hemogram parameters, bone marrow morphology, and concentration of marrow-derived granulocytic- and erythrocytic-committed stem cells. However, the trauma of surgery combined with irradiation had no apparent effects on the contralateral uterine horn with the remaining pups, with no indications of miscarriage, absorption of pups, or other complications of pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01990407
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of pre- and post-irradiation glucan treatment on pluripotent stem cells, granulocyte, macrophage and erythroid progenitor cells, and hemopoietic stromal cells (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 1240-1244 
    Details
    ISSN: 1420-9071
    Keywords: Mice ; glucan treatment ; Co60-irradiation ; stem cells, pluripotent ; granulocytes ; macrophages ; erythroid progenitor cells ; hemopoietic stomal cells ; hemopoiesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Glucan, a beta-1, 3 polyglucose, was administered to mice either 1 h before or 1 h after a 650 rad exposure to cobalt-60 radiation. Compared to radiation controls, glucan-treated mice consistantly exhibited a more rapid recovery of pluripotent stem cells and committed granulocyte, macrophage, and erythroid progenitor cells. This may partially explain the mechanism by which glucan also enhances survival in otherwise lethally irradiated mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946654
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  • 5
    Electronic Resource
    Electronic Resource
    The detection of in vitro monocyte-macrophage colony-forming cells in mouse thymus and lymph nodes (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 92 (1977), S. 203-207 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: In vitro moocyte-macrophage colony-forming cells (CFC) have been detected in the thymus (30/106 cells) and in the cervical (22/106) and mesenteric (20/106) lymph nodes (LN) of the mouse. Thymus and LN derived CFC differed from bone marrow derived CFU-c in several characteristic parameters: (1) sole specificity of PMUE to induce colony formation (CF), (2) apparent singular line of monocyte-macrophage differentiation, (3) a marked 6- to 10-day lag period prior to initiation of CF, and (4) significantly slower rates of appearance of colonies in culture after initiation of CF. Two of these parameters are shared with those CFC detected within alveolar space, peritoneal exudate and pleural effusion. These are the delay prior to CF and the singular monocyte-macrophage differentiation. These similarities suggested that T-CFC and LN-CFC are probably of similar origin and represent, as suggested by Lin and Stewart ('74), a population of progenitor cells exclusively for monocyte-macrophages.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040920208
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  • 6
    Electronic Resource
    Electronic Resource
    Detection of in vitro macrophage colony-forming cells (M-CFC) in mouse bone marrow, spleen, and peripheral blood (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 97 (1978), S. 305-313 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: In vitro macrophage colony-forming cells (M-CFC) have been detected in bone marrow (BM) (317/105 cells), spleen (SPL) (81/105), and peripheral blood leukocytes (PBL) (242/105) of the mouse. These M-CFCs were similar to those previously detected in thymus (T) (30/106) and lymph node (LN) (22/106) tissue in several respects. BM- and SPL-derived M-CFC required PMUE to consistently initiate colony formation, whereas PBL-derived M-CFC formed colonies with stimulation by either PMUE or L-cell-conditioned medium. All colonies formed showed a singular macrophage line of differentiation, a lag of 13 to 18 days prior to initiating colony formation, a marked ability to survive in culture in the absence of PMUE, and markedly slow rates of appearance in culture once colony formation was initiated. The macrophage progeny were identified on the basis of morphology, glass adherence, the phagocytosis of agar, bacteria and SRBC, and the presence of receptors for IgG. These characteristics are also shared by those macrophage CFCs observed within stimulated peritoneal exudate, pleural effusion, and alveolar space. These M-CFCs are most likely members of a large, heterogeneous population of macrophage progenitor cells distributed throughout the hemato-lymphopoietic organs, serosal cavities and surfaces, and inflammatory and alveolar tissue sites. The degree of heterogeneity may be determined in part by the influence of tissue-specific microenvironment.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040970305
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