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  • 1
    Electronic Resource
    Electronic Resource
    On the substructures of secretory granules of the chick beta islet cell
    Amsterdam : Elsevier
    Journal of Ultrasructure Research 31 (1970), S. 199-201 
    Details
    ISSN: 0022-5320
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0022-5320(70)90155-3
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  • 2
    Electronic Resource
    Electronic Resource
    On the follicle formation of the thyroid gland in the chick embryo
    Amsterdam : Elsevier
    Experimental Cell Research 25 (1961), S. 204-207 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(61)90327-5
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ciliated mucous cells found in the nasal mucosa of a patient with Kartagener's syndrome (1988)
    Springer
    European archives of oto-rhino-laryngology and head & neck 244 (1988), S. 360-362 
    Details
    ISSN: 1434-4726
    Keywords: Nasal mucosa ; Kartagener's syndrome ; Ciliated mucous cells ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Transmission electron microscopy revealed the presence of ciliated cells containing many mucous secretory granules in the nasal surface epithelium of a 13-year-old patient suffering from Kartagener's syndrome. In these cells, mucous secretory granules were accumulated in the apical cytoplasm, and the Golgi apparatus was well developed in the supranuclear region. Mucous secretory granules were discharged infrequently through the apical cell membranes by single or compound exocytosis. The cells were considered to be ciliated mucous cells, which have already been reported to be present in the lower respiratory tract but not in the upper respiratory tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00497465
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Immunocytochemical detection of triphosphoinositide in vestibular hair cells (1985)
    Springer
    Histochemistry and cell biology 82 (1985), S. 197-199 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Triphosphoinositide (TPI), an aminoglycoside receptor and a possible regulator of cationic permeation through its ability to bind with Ca++, was localized by the protein-A gold technique in vestibular sensory epithelia using an antibody highly specific to TPI. TPI was detected on the stereocilia, kinocilia, and cuticular plate of hair cells, and in the reticular membrane of supporting cells. The cilia of hair cells are damaged by aminoglycosides at a relatively early stage of toxicity. Ca++-regulated bioactivity in this area is probably involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00708205
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  • 5
    Electronic Resource
    Electronic Resource
    Polymyxin-B-binding sites in the cochlea as demonstrated by polymyxin-B/gold labeling (1986)
    Springer
    Histochemistry and cell biology 86 (1986), S. 191-194 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A polymyxin-B/bovine-serum-albumin/gold complex was used as a probe to detect the binding sites of polymyxin B on thin sections of cochlea embedded in Spurr's resin. The binding sites were found to be mainly located on the stereocilia, the cuticular plate of hair cells, the head plate of Deiters' cells, the tonofilaments in pillar cells and Deiters' cells, fibrous structures in the spiral limbus, the tectorial membrane and the basilar membrane and neural elements such as nerve endings, fibers, and the myelin sheath. The mitochondria, plasma mimbrane, and chromatin of the nuclei of the cells observed also exhibited binding. Our results suggest that phospholipids, glycoconjugates, cytoskeletal proteins and nucleic acids are responsible for this binding activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00493386
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  • 6
    Electronic Resource
    Electronic Resource
    Aminoglycoside binding sites in the cochlea as revealed by neomycin-gold labelling (1986)
    Springer
    Histochemistry and cell biology 85 (1986), S. 301-304 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Neomycin/bovine serum albumin/gold was used as a probe to detect the binding sites of aminoglycosides on the thin sections of the cochlea embedded in Spurr. The binding sites were mainly located on the stereocilia, the cuticular plate of hair cells, the head plates of Deiters' cells, fibrous structures in pillar cells, in the spiral limbus and tectorial membrane and basilar membrane, plasma membranes, mitochondria and the chromatin of various kinds of cells. Triphosphoinositide, acidic glycosaminoglycans, and RNA were considered to be responsible for the binding activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00493481
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  • 7
    Electronic Resource
    Electronic Resource
    Localization of triphosphoinositide in the cochlea (1984)
    Springer
    Histochemistry and cell biology 81 (1984), S. 157-160 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Triphosphoinositide (TPI) has been demonstrated to be a receptor for aminoglycosides in the cochlea and may regulate ionic permeability by its binding with Ca++. This phospholipid was localized by a protein A-gold technique in the cochlea at the electronmicroscopic level. TPI was prepared by a neomycin column and antibodies to it were raised in rabbits. The antibody used in this study reacted virtually only to TPI among the tested lipids. TPI was localized mainly at stereocilia, cuticular plates, head plates of Deiter's cells, plasma membrane, and mitochondria of various cells in the organ of Corti. In the vascular stria, TPI was found mainly at the plasma membrane of basal infoldings of the marginal cells. Possible physiological and pathophysiological roles of TPI in the cochlea are briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00490110
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  • 8
    Electronic Resource
    Electronic Resource
    Binding sites of an aminoglycoside in the cochlea examined by immunocytochemistry (1985)
    Springer
    Histochemistry and cell biology 83 (1985), S. 237-240 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary To localize the binding sites of aminoglycosides in the cochlea, immunocytochemistry was used with the antibody to gentamicin and the protein-A/gold complex. We found that the main binding sites were the stereocilia, the cuticular plates of hair cells, the head plates of Deiters' cells, cell filaments and the cones of pillar cells, tectorial membranes, basilar membranes, the matrix of the spiral limbus, plasma membranes, mitochondria, and the chromatin of various kinds of cells. Triphosphoinositide and acidic glycosaminoglycans are the two most likely candidates for the cause of binding activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00953990
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  • 9
    Electronic Resource
    Electronic Resource
    Morphologic effects of minocycline on the cochlea of the guinea pig (1973)
    Springer
    European archives of oto-rhino-laryngology and head & neck 204 (1973), S. 163-174 
    Details
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Wirkung von Mynocycline — ein neu sythetisiertes Antibioticum der Tetracyclin-Gruppe - wurde an der Meerschweinchen-Cochlea histochemisch und elektroneumikroskopisch untersucht. Die morphologischen Veränderungen nach Zufuhr von Minocycline fanden sich nur am Sinnesepithel der Cochlea. Zeichen der Degeneration, z. B. Vacuolen im endoplasmatischen Reticulum, sind in den äußeren Haarzellen der oberen Schnecken windung besonders deutlich zu erkennen. In den Endigungen des Nervus cochlearis und an den inneren Haarzellen zeigen sich Veränderungen weniger ausgeprägt. Stria vascularis, Prominentia und Ligamentum spirale bleiben unverändert. Die relativ große Fähigkeit der Eiweißsynthese in den Sinnesepithelzellen wird von Minocyclinzufuhr empfindlich beeinflußt, weil diesel Mittel die Verbindung mit Aminoacyl-t-RNS and Ribosomen hemmt. Infolgedessen beginut die morphologische Veränderung in der Cochlea zuerst an den Sinnesepithelzellen. Die Degeneration in den äußeren Haarzellen nimmt von der oberen zur unteren Schneckenwindung zu. Diese Erscheinung weist darauf hin, daß der Eiweißmetabolismus in der oberen Windung leichter störbar ist all in der unteren.
    Notes: Summary The morphologic effects of minocycline on the cochlea of guinea pigs were studied by means of histochemistry and electron microscopy. Minocycline is a newly synthesized antibiotic of the tetracycline group and inhibits protein synthesis. The reactions were mainly observed in the cochlear sensory epithelia. Degenerative changes appeared first in the outer hair cells in the upper turn showing vacuolization of endoplasmic reticulum and so on, but nerve endings and inner hair cells showed little change. Stria vascularis, spiral prominence and spiral ligament were almost intact. The protein synthesis in the organ of Corti is stronger than in stria vascularis. This may be the reason why the former was more strongly damaged than the latter. The degeneration of outer hair cells started from the upper turn to the lower. This may indicate that the protein metabolism is more vulnerable in the upper turn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301833
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  • 10
    Electronic Resource
    Electronic Resource
    Cupulogenesis and glycoconjugates in the labyrinthine ampulla as revealed by WGA-gold labeling (1987)
    Springer
    European archives of oto-rhino-laryngology and head & neck 244 (1987), S. 112-116 
    Details
    ISSN: 1434-4726
    Keywords: Wheat germ agglutinin-gold ; Ampulla ; Mongolian gerbil ; Cupulogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the distribution of wheat germ agglutinin (WGA)-bindable glycoconjugates in the vestibular ampulla of mongolian gerbils. WGA was conjugated with gold particles and applied to Lowicryl K4M sections of the ampulla. WGA-binding sites were found on the cupula and some of the secretory granules and Golgi apparatuses in the supporting cells of the sensory epithelia. The granules were seen to secrete into the endolymphatic space through reticular membrane. It is likely, therefore, that glycoconjugates are glycosylated at the Golgi apparatus in the supporting cells, stored in the granules, and secreted through the reticular membrane into the endolymphatic space to be used as a component of the cupula. The cell membranes of various cells, connective tissue filaments in the perilymphatic space and the cytoplasm of melanocytes were also labeled with WGA-gold.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00458560
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