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  • 1
    Electronic Resource
    Electronic Resource
    Spontaneous uterine adenocarcinomas in aged rats and their relation to endocrine imbalance (1990)
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 623-628 
    Details
    ISSN: 1432-1335
    Keywords: Spontaneous uterine adenocarcinoma ; Donryu rat ; Endocrine imbalance ; Estrogen ; Estrogen: progesterone ratio (E2∶P ratio)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In addition to spontaneous uterine endometrial adenocarcinomas at a high incidence (35.1 %), development of endometrial hyperplasia/adenoma was also frequently detected in rats of the Donryu strain. The total yield of all observed proliferative endometrial lesions was very high (60.6%). The tumors arose commonly in the uterine horn of aged rats. Histologically, most demonstrated glandular structures, consisting of cuboidal or columnar cells with weak eosinophilic or basophilic cytoplasm ↭d large nuclei. In about half of the animals with adenocarcinomas, metastasis to remote organs such as the lung was observed. Histological examination of the ovary and vaginal epithelium revealed ovarian cysts, atrophy of the ovary and cornification of the vaginal epithelium more frequently in rats with endometrial carcinomas than in animals without tumors. These findings indicate that adenocarcinoma development in Donryu rats is associated with endocrine imbalance [increased serum estrogen: progesterone (E2∶P)ratios]. By comparative investigation of strain differences, it was confirmed that irregular estrous cycles began earlier with higher incidence in Donryu rats than in F344 rats, a low-incidence strain. Histological findings of the ovary and vaginal epithelium also suggested relatively increased estrogen levels in Donryu rats compared to F344 rats. Estimated plasma values of gonad steroids showed that the E2∶P ratio in Donryu rats at 12 months of age was about five times that in F344 rats. These results therefore indicate that hormone imbalance, particularly an increased E2∶P ratio, may play an important role in the spontaneous occurrence of endometrial adenocarcinoma in Donryu rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01637084
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  • 2
    Electronic Resource
    Electronic Resource
    Induction of digestive-tract tumors in F344 rats by continuous oral administration of N-butyl-N-nitrosourea (1984)
    Springer
    Journal of cancer research and clinical oncology 107 (1984), S. 32-37 
    Details
    ISSN: 1432-1335
    Keywords: Chemical carcinogenesis ; N-Butyl-N-nitrosourea ; Alkylnitrosourea ; Upper-digestive-tract tumor ; Vaginal tumor ; F344 rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Male and female F344/DuCrj rats were administered N-butyl-N-nitrosourea at a concentration of 400 ppm in their drinking water. By the 50th week of the experiment, the cumulative incidence of upperdigestive-tract tumors was as high as 35/39 (90%) and 34/39 (87%) in male and female rats, respectively. Among these, esophageal and forestomach tumors occurred most frequently. Except one female rat with fibroma, upper-digestive-tract neoplasms were of the epithelial type—papilloma, squamous-cell carcinoma or adenocarcinoma. In female rats, vaginal tumors were induced in 16 (41%) animals. Ear-duct tumors and hematopoietic neoplasms were also induced in both sexes of rats, with incidence of less than 21%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395487
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  • 3
    Electronic Resource
    Electronic Resource
    Malignant fibrous histiocytomas induced in rats by polymers (1984)
    Springer
    Journal of cancer research and clinical oncology 108 (1984), S. 364-365 
    Details
    ISSN: 1432-1335
    Keywords: Malignant fibrous histiocytoma ; Polymers ; Foreign-body tumorigenesis ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five polymeric materials (3 polyvinyl chlorides, 1 polyhydroxyethyl methacrylate, and 1 dimethyl polysiloxane) were implanted into subcutaneous (SC) tissues of rats. Subcutaneous tumors developed in all experimental groups. The incidences of the tumors differed however, although the experimental conditions were the same for all these materials. This result indicates that chemical characteristics of the materials may influence the incidence of SC tumors. From the histological and electron-microscopic findings many of these tumors were diagnosed as malignant fibrous histiocytomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390475
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  • 4
    Electronic Resource
    Electronic Resource
    Induction of sertoli cell tumors in the rat ovary by N-alkyl-N-nitrosoureas (1986)
    Springer
    Journal of cancer research and clinical oncology 111 (1986), S. 173-176 
    Details
    ISSN: 1432-1335
    Keywords: Sertoli cell tumor ; Ovary ; Donryu rat ; N-Ethyl-N-nitrosourea ; N-Propyl-N-nitrosourea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Relatively high incidences of Sertoli cell tumors of the ovary were induced in Donryu rats given a 400 ppm N-ethyl-N-nitrosourea solution as drinking water for 4 weeks or a single dose of 200 mg/kg N-propyl-N-nitrosourea by stomach tube. Typical Sertoli cell tumors were composed of solid areas showing tubular formation. Tubules were lined by tall, columnar cells having abundant, faintly eosinophilic, often vacuolated cytoplasm, and basally oriented round nuclei. In some cases, Sertoli cell tumors were found to be mixed with granulosa cell tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400760
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  • 5
    Electronic Resource
    Electronic Resource
    Induction of lung tumors and peritoneal mesotheliomas in F344 rats given intragastric N-propyl-N-nitrosourea and histochemical, immunohistochemical, and ultrastructural characteristics of induced mesotheliomas (1988)
    Springer
    Journal of cancer research and clinical oncology 114 (1988), S. 259-265 
    Details
    ISSN: 1432-1335
    Keywords: N-Propyl-N-nitrosourea ; F344 rat ; Lung tumor ; Mesothelioma ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary N-Propyl-N-nitrosourea is a strong leukemogen that induces myelogenic leukemia in Donryu rats and thymic lymphoma in F344 rats when administered in drinking water. In the present study, a single or multiple doses of PNU (total 500 mg/kg body weight) was given to young male and female F344 rats via a stomach tube. The results demonstrated that the percentage of tumor-bearing rats was 100% in all PNU-treated male groups, while that of the control group was 46%. Predominant tumors induced by PNU in male rats were lung adenoma/adenocarcinoma followed by peritoneal mesothelioma, and forestomach papilloma. In females, the tumor incidence of PNU-treated groups varied between 58% and 92% while that of the control group was 42%. Although pituitary tumor was the most frequent tumor in PNU-treated female rats, it was thought to be spontaneous since its incidence in each experimental group was not statistically different from that of the control group. Lung tumors and forestomach papillomas were also induced by PNU in female rats. No thymic lymphoma, however, was found in any of the PNU-treated groups of either sex. Lung tumors developed in almost all PNU-treated male rats and in about one-third of PNU-treated female rats. Mesothelioma was induced only in male rats, and its incidence depended on the treatment schedule. Induced mesotheliomas were extensively examined histologically, histochemically, immunohistochemically, and electron microscopically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405831
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  • 6
    Electronic Resource
    Electronic Resource
    Neurochemical and histological analysis of motor dysfunction observed in rats with methylnitrosourea-induced experimental cerebellar hypoplasia (1992)
    Springer
    Neurochemical research 17 (1992), S. 223-231 
    Details
    ISSN: 1573-6903
    Keywords: Methylnitrosourea ; rat ; cerebellum ; neurotransmitters ; motor-incoordination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histological and neurochemical changes related to motor dysfunction observed in rats after neonatal treatment with nitrosoureas were examined. Neonatal rats received subcutaneous injections of methylnitrosourea (MNU: 0.125 mmol/kg, s.c.) or ethylnitrosourea (ENU: 0.25 mmol/kg, s.c.) daily at 4,5,6 and 7 days post partum, a period of cerebellar granule cell, stellate cell and basket cell formation. At 14 days and 45 days after birth, MNU-treated rats displayed a lowering in motor coordination skills measured by tests of retainment ability on a rod of 26 mm diameter, chinningclimbing ability on parallel rods or retainment ability on a rotating rod. Histological examination at 14 days after birth showed a cerebellar hypoplasia with reduced cellularity of the internal granule cell layer and a disperse disposition of Purkinje cells in the granule cell layer. Cerebellar growth and cerebellar content and concentration of DNA were remarkably reduced in the MNU-treated rat. The degree of the reduction in cerebellar content of glutamic acid paralleled the degree of the cerebellar hypoplasia at 14 and 45 days after birth. In contrast, the concentrations of gamma-aminobutyric acid, acetylcholine, 5-hydroxytryptamine and norepinephrine were significantly increased by MNU treatment. ENU treatment control did not exert any significant changes in the neurotransmitters and motor coordination. These results suggest that the motor dysfunctions observed in MNU treated rats are induced by unbalanced output activities from Purkinje cells to motor neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00966663
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  • 7
    Electronic Resource
    Electronic Resource
    Development of invasive adenocarcinoma in a long-standing diverted ileal J-pouch for ulcerative colitis (2000)
    Springer
    Diseases of the colon & rectum 43 (2000), S. 101-104 
    Details
    ISSN: 1530-0358
    Keywords: Ulcerative colitis ; Ileal J-pouch ; Adenocarcinoma in an ileal J-pouch ; Ileal adenocarcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of a 50-year-old male with ulcerative colitis who developed well-differentiated adenocarcinoma in the ileal J-pouch, which had been defunctioning for 18 years. The extension of the carcinoma in the pouch suggested that it had recently appeared in the pouch. Monitoring by endoscopic examination and biopsy or pouch excision seems to be an appropriate action if a pouch is out of the fecal stream.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02237251
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