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  • 1
    ISSN: 1432-0428
    Keywords: Key words Genetics, diabetes mellitus, mitochondria, maternal, deafness.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Non-insulin-dependent diabetes mellitus (NIDDM) has a strong genetic component and maternal factors have recently been implicated in disease inheritance. The mitochondrial myopathies are a group of diseases which often show maternal inheritance as a result of mtDNA defects; some patients have impaired glucose tolerance. Occasional families with maternally inherited diabetes and deafness associated with a deletion or point mutation of mtDNA have been reported. To assess the importance of mitochondrial gene defects in NIDDM, 150 unrelated diabetic subjects from Wales, UK and 68 unrelated patients with diabetes and at least one affected sibling from England, UK were studied. Southern blot analysis did not show any large mtDNA deletions or duplications. One patient had a mutation in the mitochondrial tRNAleu(UUR) gene at bp 3243. This mutation is commonly associated with the syndrome of mitochondrial encephalomyopathy, lactic acidosis and stroke like episodes (MELAS). Study of this patient and his siblings showed a distinct form of late-onset diabetes associated with nerve deafness but no clinical features of the MELAS syndrome. No diabetic subject was shown to have the mtDNA mutation at position 8344 (tRNAlys) which has previously been described in the syndrome of mitochondrial encephalomyopathy and red-ragged fibres (MERRF). The role of other mitochondrial gene defects in diabetes and the pathophysiological basis of glucose intolerance in patients with the MELAS mutation requires further elucidation. [Diabetologia (1994) 37: 372–376]
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Genetics ; diabetes mellitus ; mitochondria ; maternal ; deafness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Non-insulin-dependent diabetes mellitus (NIDDM) has a strong genetic component and maternal factors have recently been implicated in disease inheritance. The mitochondrial myopathies are a group of diseases which often show maternal inheritance as a result of mtDNA defects; some patients have impaired glucose tolerance. Occasional families with maternally inherited diabetes and deafness associated with a deletion or point mutation of mtDNA have been reported. To assess the importance of mitochondrial gene defects in NIDDM, 150 unrelated diabetic subjects from Wales, UK and 68 unrelated patients with diabetes and at least one affected sibling from England, UK were studied. Southern blot analysis did not show any large mtDNA deletions or duplications. One patient had a mutation in the mitochondrial tRNAleu(UUR) gene at bp 3243. This mutation is commonly associated with the syndrome of mitochondrial encephalomyopathy, lactic acidosis and stroke like episodes (MELAS). Study of this patient and his siblings showed a distinct form of late-onset diabetes associated with nerve deafness but no clinical features of the MELAS syndrome. No diabetic subject was shown to have the mtDNA mutation at position 8344 (tRNAlys) which has previously been described in the syndrome of mitochondrial encephalomyopathy and red-ragged fibres (MERRF). The role of other mitochondrial gene defects in diabetes and the pathophysiological basis of glucose intolerance in patients with the MELAS mutation requires further elucidation.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Advances in science and technology Vol. 46 (Oct. 2006), p. 73-78 
    ISSN: 1662-0356
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Natural Sciences in General , Technology
    Notes: Deep-level defects related with 5d transition metal, osmium (Os) have been studied in ntypeGaAs. Os has been incorporated in epitaxial n-GaAs layers in situ, during growth by lowpressuremetal-organic chemical vapour phase epitaxy (MOVPE) technique. Mesa p+nn+ junctiondiodes are fabricated for investigations by deep level transient spectroscopy (DLTS). Two deeplevelpeaks, observed in majority carrier (electron) emission spectra, Os1 and Os2, show asignificant shift in peak positions to lower temperatures with the applied junction reverse bias,demonstrating enhancement of the thermal emission rate by the junction electric field. DoublecorrelationDLTS (DDLTS) measurements have been employed for accurate quantitativeinvestigations of the observed field dependence. However, in view of the relatively smallconcentration of the deep level Os1, this technique is found to yield reliable data only for the deeplevel corresponding to the dominant peak, Os2. Detailed data have been obtained on the field effectfor Os2, extending over junction electric field values 3 x 106 V/m - 1.2 x 107 V/m. The measuredemission rate signatures show a reduction of the thermal activation energy from 0.48 eV to 0.21 eVfor Os2 over this electric field range. Analysis of the data in terms of the recent theoretical work onfield dependence indicates that Os2 is associated with a substitutional Os donor
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 9 (1989), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: Ground water remediation of volatile organic compound (VOC) contamination at a site in Michigan was initiated as a result of a consent agreement between the Michigan Department of Natural Resources (MDNR) and the responsible party. Under the direction of the MDNR, the responsible party conducted a remedial investigation/feasibility study using federal guidelines to define the extent of contamination at the site and to select a response action for site remediation. The selected alternative included a combination of ground water extraction, treatment, and recharge, and soil flushing. The extraction system withdraws ground water from various depths in heavily contaminated areas. The ground water is treated using an air stripper. A spray distribution system spreads effluent from the stripper over a recharge basin constructed over the most contaminated areas. Additional contaminant removal is achieved by volatilization from the spray and percolation through the gravel bed. Recharge water moves downward through the contaminated soils, thus flushing residual soil contaminants. The initial operating data demonstrated that the system can effectively remove trichloroethylene (TCE) from ground water (approximately 95 percent overall removal efficiency). The annualized capital and operation and maintenance (O & M) costs of the remedial action were estimated for several operating periods (15, 20, and 30 years).
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Inorganica Chimica Acta 61 (1982), S. 25-31 
    ISSN: 0020-1693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 58 (1987), S. 1242-1244 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: This paper introduces the design of a signal processing circuit which can be used in conjunction with additional arrangement for measuring gas mass flow rate. Measurement is based on Bernoulli's equation for subsonic flow. Voltages representing gas static pressure, static temperature, and difference pressure generated across an orifice plate are supposed to be taken from appropriate transducers. These voltages are processed with this circuit in such a way as to produce a digital number representing the mass flow rate value. The circuit shows a good accuracy result with uncertainty of about ±0.1%.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 38 (1973), S. 4028-4031 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Inorganic and Nuclear Chemistry Letters 7 (1971), S. 53-56 
    ISSN: 0020-1650
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Fluorine Chemistry 3 (1973), S. 55-61 
    ISSN: 0022-1139
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Inorganic and Nuclear Chemistry 37 (1975), S. 1535-1537 
    ISSN: 0022-1902
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
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