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  • 1
    Electronic Resource
    Electronic Resource
    The effects of metiamide and H1 receptor blocking agents on anaphylactic response in guinea-pigs (1979)
    Springer
    Inflammation research 9 (1979), S. 467-473 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of metiamide and of four H1 receptor blocking agents (mepyramine, promethazine, clemastine and ketotifene) on anaphylactic reaction were studied in the guinea-pig. The H1 blockers conferred partial protection which shows that with the experimental protocol utilized (challenge injection with high doses of antigen), histamine plays a lesser role than other mediators released or synthesized. Metiamide (30.0 mg/kg i.v.) noticeably enhanced the increase in pulmonary resistance observed during anaphylactic reaction and reduced the protective effect of the H1 antagonists on this parameter and on histamine release. These effects might be explained by an inhibition — at least partial — of the negative feed-back mechanism through which histamine controls its own release, or by a specific action of metiamide in high doses. The transient tachycardia initially observed in anaphylactic shock is partly related to stimulation of cardiac H2 receptors by the histamine released, since it is suppressed by metiamide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968112
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of atropine on anaphylactic shock in the guinea-pig (1982)
    Springer
    Inflammation research 12 (1982), S. 103-107 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of atropine, 2 mg/kg i.v., on anaphylactic shock were studied in guinea-pigs sensitized to ovalbumin. Atropine only moderately reduced (−31%) the increase in pulmonary resistance observed and slightly prolonged (+26%) the survival time in pretreated animals compared with controls. These effects, however, were not statistically significant. The drug temporarily improved ventilation but had no influence on haematosis. On the other hand, atropine significantly reduced the amount of histamine released (−60%) and of GMPc synthetized in the lung (−21%). The levels of AMPc and prostaglandins E1, E2 and F2α remained comparable to those of control animals. These results suggest that the reflex-induced action of the cholinergic system during anaphylaxis primarily affects large-calibre airways and that the role of acetylcholine in severe reactions is moderate when compared with the direct action of other mediators.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01965117
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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