Bibliothek

feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
Materialart
Erscheinungszeitraum
  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 27 (2002), S. 0 
    ISSN: 1365-2230
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary The paradoxical acute exacerbation of pre-existing chronic idiopathic urticaria accompanied by intense generalized pruritus, facial oedema, and dyspnoea in a 36-year-old-woman 3–4 h after a single oral dose of 10 mg cetirizine (Zyrtec® tablets), suggested the presence of an underlying intolerance reaction. However, a type I hypersensitivity reaction also had to be excluded. Detailed allergy testing supported the view that the patient had suffered an intolerance reaction to cetirizine. This is the third known case of most probably a nonallergic generalized urticaria following the administration of cetirizine, a drug with extensive usage worldwide. However a type I sensitization to cetirizine is indeed possible, as has been demonstrated in this research with the verification of cetirizine-specific IgE antibodies in one of the control sera.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc
    Experimental dermatology 13 (2004), S. 0 
    ISSN: 1600-0625
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Ionotropic glutamate receptors (ligand-gated, ion-channel proteins) of the N-methyl-d-aspartate (NMDA) receptor type could enable a transmembranous calcium influx from the extracellular space. Though ionotropic glutamate receptors are predominantly neuronal receptors, they are also expressed in non-neuronal tissues like keratinocytes. Therefore, investigations were performed to study the function of NMDA receptors in HaCaT cells. The intracellular calcium concentration of HaCaT cells was studied under the influence of the selective receptor agonist NMDA and the selective NMDA antagonist MK-801. The proliferation of HaCaT cells was investigated using the crystal-violet method. Furthermore, the expression of Cytokeratin 10 and Filaggrin was examined in HaCaT cells after blocking NMDA receptors with MK-801. Using NMDA, there was a significant increase in the number of HaCaT cells showing elevated intracellular calcium concentration, at a dose between 25 µm and 1 mm (up to 84.6% of cells). The NMDA-associated calcium influx could be significantly suppressed by prior application of MK-801. There was no influence of NMDA on the proliferation of HaCaT cells. There was also no cytotoxic effect of NMDA (up to 1 mm). The expression of Cytokeratin 10 and Filaggrin could be suppressed by blocking NMDA receptors with MK-801. The investigations show that glutamate receptors of the NMDA-type play a role in the differentiation of HaCaT cells by regulating their intracellular calcium concentration.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...