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  • 1
    Electronic Resource
    Electronic Resource
    Antibiotic concentrations in the groin wound after vascular prosthetic implantation (1991)
    Springer
    Pharmacy world & science 13 (1991), S. 179-181 
    Details
    ISSN: 1573-739X
    Keywords: Ceftazidine ; Cefuroxime ; Groin ; Implants, artificial ; Vascular surgery ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The kinetics of systemically and locally administered cefuroxime or ceftazidime in wound fluid were investigated in the period after vascular prosthetic implantation. Cefuroxime or ceftazidime was administered intravenously in patients. Simultaneously 250 mg ceftazidime or cefuroxime was added to preclotted blood. Locally administered antibiotics could not be detected in our samples. In groin fluid samples 24–48 h after the operation the average concentration of cefuroxime was 8.3 and of ceftazidime 5.0 mg/l. The decline of the concentration of cefuroxime or ceftazidime in groin fluid seems to be much slower than one would expect from the half-lives of the antibiotics. We conclude that cefuroxime and to a lesser extent ceftazidime are suitable as prophylactic agents in arterial reconstruction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957743
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of water-soluble vitamins in total parenteral nutrition solution by high pressure liquid chromatography (1989)
    Springer
    Pharmacy world & science 11 (1989), S. 169-174 
    Details
    ISSN: 1573-739X
    Keywords: Ascorbic acid ; Chromatography, high pressure liquid ; Drug stability ; Folic acid ; Nicotinamide ; Parenteral nutrition ; Pyridoxine ; Quantitative analysis ; Riboflavin 5′-phosphate ; Thiamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A stability-indicating high pressure liquid chromatographic method was developed to determine the stability of water-soluble vitamins in total parenteral nutrition mixtures. Folic acid and thiamine were determined by direct injection and precolumn enrichment, followed by UV detection. Nicotinamide and pyridoxine were determined simultaneously without sample pretreatment by UV detection of nicotinamide and fluorescence detection of pyridoxine. Riboflavin 5′-phosphate was also determined without elaborate sample handling and by fluorescence detection. Ascorbic acid was determined as the sum of ascorbic acid and dehydroascorbic acid. After derivatization to a quinoxaline the latter substance was determined by direct injection and fluorescence detection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959466
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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