ISSN:
1433-0350
Keywords:
Hydrocephalus
;
Cerebral energy metabolism
;
31P-MRS
;
High-energy phosphorus compound
;
Lactate dehydrogenase
;
Isoenzyme
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Energy metabolism in kaolin-induced hydrocephalic rat brain was assessed by means of 31-phosphorus magnetic resonance spectroscopy and measurement of the activity of lactate dehydrogenase (LDH) as well as its isoenzyme patterns. Decreases in beta-adenosine triphosphate and phosphocreatine were observed in hydrocephalic rat brains. While the intracellular pH was decreased at 2 to 4 weeks, it showed some recovery 6 weeks after injection of kaolin. The activity of LDH increased in the hydrocephalic state, and its isoenzyme-pattern changes were as follows: the LDH5 fraction was predominant in 1-week to 4-week rats while the LDH4 fraction was predominant in 4-week rat brains, and at 6-weeks, the LDH4 and LDH5 fractions were decreased. These data from rat brains with kaolin-induced hydrocephalus indicate that anaerobic glycolysis is the primary pathway of energy metabolism in the acute hydrocephalic state, while in the chronic state the emphasis shifts to aerobic glycolysis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00302225
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