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  • 1
    Digitale Medien
    Digitale Medien
    Oxford, UK : Munksgaard International Publishers
    Pediatric allergy and immunology 14 (2003), S. 0 
    ISSN: 1399-3038
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The objective of the study was to evaluate the risk of asthma in children who had undergone an adenoidectomy, an operation frequently performed on children with glue ear or recurrent otitis media. Two surveys were carried out, a nation-wide questionnaire returned by 483 individuals (survey A) and a survey of hospital discharge records involving 1616 children who had undergone an adenoidectomy and 161 control children who had undergone probing of the nasolacrimal duct due to congenital obstruction (survey B). The questionnaire (survey A) showed that an adenoidectomy before the age of 4 years was associated with asthma (OR 3.19, 95% CI 1.25; 8.13) and with allergy to animal dust (OR 2.50, 95% CI 1.27; 4.95). In survey B, asthma diagnosis was retrieved from the national asthma register. It showed also that adenoidectomy at an early age was associated with an increased risk of asthma (OR 6.74, 95% CI 2.99; 15.2). There was an association between asthma and adenoidectomy, even before adenoidectomy had actually been performed. The risk of asthma was highest among children who had had adenoidectomy because of recurrent otitis media. The observed association between an adenoidectomy and asthma may be explained by an underlying factor predisposing to both recurrent otitis media and asthma.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1574-695X
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: Alloiococcus otitidis is a recently discovered pathogen of otitis media. However, only a limited number of studies are available about the pathogenic and immunological role of A. otitidis. The aim of this study was to investigate the activation and the cytokine production of human peripheral blood lymphocytes at the early immune response after stimulation with A. otitidis. After stimulation of whole human peripheral blood lymphocytes for 18 h with whole killed A. otitidis or the three major middle ear pathogens (Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis), the expression of CD69 and the production of cytokines were analyzed. The expression of CD69 on T cells and B cells was dose-dependently enhanced after stimulation with A. otitidis. The release of interleukin (IL)-12 was induced after stimulation with A. otitidis, whereas the release of IL-4 was not induced after stimulation with A. otitidis. In addition, the release of interferon (IFN)-γ was induced after stimulation with A. otitidis. Although the release of IFN-γ started within 18 h after stimulation with A. otitidis, intracellular production of IFN-γ was not observed in either CD4+ T cells or CD8+ T cells within 18 h upon stimulation. The patterns of CD69 expression and T helper-type 1 (Th1)-promoting cytokines production were similarly shown when human peripheral blood lymphocytes were stimulated with the other three major pathogens. Our results suggest that A. otitidis has sufficient immunogenic potential to modulate a host immune response, like the other three major middle ear pathogens, and also suggest that the immunogenicity of A. otitidis is very similar, at the early immune response, to that of the three major middle ear pathogens.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Quarante-sept patients (34 hommes et 13 femmes) âgés de plus de 75 ans (moyenne 79.7±3.8 SD) présentant une rupture d'anévrysme de l'aorte abdominale ont été opérés entre 1977 et 1986. Chez 16 patients (34%), l'anévrysme était déjà connu. Dix-sept patients (36%) ont été opérés 6 heures ou plus après le début de la rupture; 26 (55%) étaient en état de choc avant l'opération. Le diamètre moyen des anévrysmes était de 8.9±2.6 cm (SD) et la perte sanguine moyenne était de 8.5±7.8 litres. La durée moyenne de l'intervention était de 220±96 minutes. La mortalité à un mois était de 60% (28 patients) et 63% (12 patients) présentaient des complications postopératoires, le plus souvent des pneumopathies. La survie à 5 ans était de 26%. Les facteurs de risque associés à une mortalité élevée et à un mauvais prognostic étaient la présence de choc opératoire, le grand âge et la présence d'un anévrysme diagnostiqué mais non traité.
    Kurzfassung: Resumen Cuarenta y siete pacientes (34 hombres y 13 mujeres) mayores de 75 años (promedio: 79.7±3.8) con aneurismas rotos de la aorta abdominal fueron operados entre 1977 y 1986. En 16 pacientes (34%) el aneurisma había sido previamente diagnosticado. Diez y siete pacientes (36%) exhibieron demora de 6 horas o más en la iniciación del tratamiento y 26 (55%) estuvieron en shock en la fase preoperatoria. El diámetro promedio del aneurisma fue 8.9±2.6 centímetres y la cantidad promedio del sangrado operatorio fue 8.5±7.8 litres. El tiempo operatorio promedio fue 220±96 minutos. La mortalidad a un mes fue 60% (28 pacientes) y 63% (12 pacientes) de los sobrevivientes sufrieron complicaciones postoperatorias, principalmente neumonía. La tasa de sobrevida a 5 años fue 26%. En cuanto al análisis de los factores de riesgo asociados con mortalidad, el shock preoperatorio, la edad avanzada, y un aneurisma aórtico previamente diagnosticado y no tratado aparecieron asociados con un pronóstico significativamente peor.
    Notizen: Abstract Forty-seven patients (34 males and 13 females) over 75 years of age (mean: 79.7±3.8 SD) suffering from a ruptured abdominal aortic aneurysm were operated on between 1977 and 1986. In 16 patients (34%), the aneurysm had been diagnosed previously. Seventeen patients (36%) had a delay of 6 hours or more in the beginning of the treatment and 26 (55%) were in shock preoperatively. The mean diameter of the aneurysms was 8.9±2.6 cm (SD) and the mean operative bleeding was 8.5±7.8 (SD) liters. The mean operating time was 220±96 (SD) minutes. The 1-month mortality was 60% (28 patients) and 63% (12 patients) of survivors had postoperative complications, mostly pneumonia. The 5-year survival rate was 26%. In the analysis of risk factors associated with death, preoperative shock, old age, and a previously diagnosed but untreated abdominal aortic aneurysm were associated with a significantly worse prognosis.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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