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  • 1
    Electronic Resource
    Electronic Resource
    Bioavailability of suckable tablets of oral N-acetylcysteine in man (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 419-421 
    Details
    ISSN: 1432-1041
    Keywords: N-Acetylcysteine ; oral administration ; bioavailability ; healthy subjects ; suckable formulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and bioavailability of suckable tablets and granules of N-acetylcysteine (NAC) have been compared after oral administration of 400 mg doses to 10 healthy volunteers. The oral bioavailability of the NAC tablets was 103%. In a multiple dosing study of the same tablets in the same subjects, a high maintenance plasma level of NAC was revealed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558514
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 207-208 
    Details
    ISSN: 1432-1041
    Keywords: diclofenac ; oral administration ; bioavailability ; healthy subjects ; diclofenac hydroxyethylpyrrolidine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A pharmacokinetic study in man has been made of a new dosage form of diclofenac hydroxyethylpyrrolidine (DIEP); soluble salt packed in sachets was compared with diclofenac sodium as enteric coated tablets. Oral DIEP 2×50 mg showed a significant difference in absorption kinetics (ka, lag time and tmax) as compared to oral diclofenac sodium 2×50 mg. A relevant plasma concentration of diclofenac was detected just 15 min after DIEP, while diclofenac sodium produced a measurable plasma concentration only 0.5–1 h after the treatment. Cmax and t1/2 after DIEP and diclofenac sodium were comparable. Comparison of the two AUC values showed that DIEP was bioequivalent to diclofenac sodium (Q=100%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265987
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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