ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract— The concentrations of the polyamines and putrescine were measured in the brains of human infants during fetal and early postnatal development. The concentrations of the amines were also measured in the brains of children who were malnourished during the first 2 years of life. In the brains of the adequately-nourished infants there were differences in the developmental profiles of the amines between different regions of the brain, and the changes in polyamine concentrations paralleled changes in nucleic acid accumulation. The concentration of putrescine was much higher than that of the polyamines in all regions of the brain, and in the brain stem there were marked increases in putrescine concentration at the time of most rapid rate of myelination. Putrescine also increased markedly in the forebrain at the time of neuroblast multiplication in the fetus. In children malnourished during the first year of life there were reductions in the concentrations of spermidine and putrescine in the forebrain and brainstem, but spermine was unaffected. Malnutrition had no effect on the concentration of any of the amines in the cerebellum.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1977.tb12324.x
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