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  • 1
    Electronic Resource
    Electronic Resource
    Breast milk of atopic mothers provides their infants with normal amounts of w-6-fatty acids (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 3 (1992), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Impaired function of the enzyme δ-6-desaturase has been proposed as a pathogenetic factor for atopic disease, especially eczema. Such a defect would lead to an increase in linolic acid and a decrease of its metabolic products (e. g. γ-linolenic acid and arachidonic acid). If a general defect were present in atopic mothers it would be detectable from the distribution of w-6-fatty acids in breast milk. We analysed the fatty acid pattern of breast milk samples of 29 healthy, 23 atopie mothers with allergic rhinitis or allergic bronchial asthma and of 20 mothers with atopic eczema. Fatty acid patterns in the breast milk of atopic mothers with rhinoconjunctivitis or bronchial asthma, non-atopic mothers and in those with atopic eczema were almost identical with respect to the mean values, 95% confidence intervals of the mean and ranges of the individual values of fatty acids. Additionally, the ratio of linoleic acid/dihomo-γ-linolenic acid + arachidonic acid as a measure of δ-6-desaturase activity did not differ between the groups. Our results do not confirm an impaired activity of δ-6-desaturase in breast milk of atopic mothers. Thus, the biochemical basis and rationale for supplementing lactating atopic mothers with γ-linolenic acid preparations seem questionable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3038.1992.tb00038.x
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  • 2
    Electronic Resource
    Electronic Resource
    Are deficiencies of prostaglandin-E-mediated immunoregulation involved in increased IgE synthesis of atopic mononuclear cells in vitro? (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 46 (1991), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We demonstrate that spontaneous in vitro immunoglobulin E synthesis of atopic peripheral blood mononuclear cells could be suppressed by the addition of 10−6 M to 10−5 M prostaglandin E1 (PGE1) or PGE2. Impaired suppressor T lymphocyte maturation and function in atopic individuals are explained by an insufficient transmission of prostaglandin E (PGE) signals during thymic lymphocyte differentiation as well as an impaired ability of the atopic immune system to activate suppressor T cells by PGE-mediated feed back mechanisms. Decreased levels of 6-desaturated PGE-precursor fatty acids in plasma, T lymphocytes, monocytes, adipose tissue and breast milk have been observed in atopic individuals. These insights might offer a novel approach to the prevention of atopic disease by substitution of the atopic pregnant and nursing woman and her newborn infant with long-chain ω-6-fatty acids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1991.tb00612.x
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  • 3
    Electronic Resource
    Electronic Resource
    Decreased stratum corneum cerarnides in atopic individuals—a pathobiochemical factor in xerosis? (1988)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 119 (1988), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1988.tb03262.x
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  • 4
    Electronic Resource
    Electronic Resource
    Retrospective radiographic study of skeletal changes after long-term etretinate therapy (1987)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 116 (1987), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Radiographic skeletal examinations were performed in eight adult patients who had received the aromatic retinoid etretinate for various disorders of keratinization over periods ranging from 1 to 7 years. Age- and sex-matched controls were also examined. In all the patients, alterations of ossification were found to a varying degree, including calcification of the anterior spinal ligament, vertebral hyperostoses at the anterosuperior and anteroinferior margins of the vertebral bodies, unilateral bridging of vertebral bodies, hyperostoses of the calcanei at the insertion of the plantar ligament and bone accretion at the anterolateral lips of the acetabula. All the bone changes were asymptomatic. Serum calcium, inorganic phosphate, alkaline phospha-tase, calcitonin and parathormone were within normal physiological ranges. In general, the bone changes observed after long-term etretinate treatment closely resembled the effects of isotretinoin on the skeleton.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1987.tb05813.x
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  • 5
    Electronic Resource
    Electronic Resource
    The role of lecithin : cholesterol acyltransferase in high density lipoprotein"3/high density lipoprotein"2 interconversion
    Amsterdam : Elsevier
    Clinica Chimica Acta 119 (1982), S. 225-236 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(82)90334-5
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  • 6
    Electronic Resource
    Electronic Resource
    Lipid composition of outer stratum corneum and nails in atopic and control subjects (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 549-551 
    Details
    ISSN: 1432-069X
    Keywords: Ceramides ; Epidermal lipids ; Nail lipids ; Water barrier function ; Atopic dry skin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00371952
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  • 7
    Electronic Resource
    Electronic Resource
    Influence of oral isotretinoin treatment on the composition of comedonal lipids. Implications for comedogenesis in acne vulgaris (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 97-102 
    Details
    ISSN: 1432-069X
    Keywords: Acne ; Isotretinoin ; Comedonal lipids ; Follicular hyperkeratinization ; Epidermal cholesterol sulfate ; Desquamation ; Comedo-genesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One of the primary events in the pathogenesis of acne vulgaris is abnormal follicular keratinization. Since oral isotretinoin therapy reduces follicular hyperkeratinization in acne, our study has been designed to determine whether epidermal lipid composition of the epithelium of sebaceous follicles is affected by isotretinoin treatment. Noninflamed early comedones obtained from ten patients with nodulocystic acne before and after the 6th week of isotretinoin therapy (mean daily dose 0.7 mg/kg b.wt.) were used as probes of the hyperkeratinizing follicular epithelium. Comedonal lipids were analyzed by high-performance thin-layer chromatography. Oral isotretinoin caused a decrease of the comedonal glyceride fraction by 36% (P〈0.01), whereas free sterols and total ceramides increased by 34% (P〈0.10) and 19%, respectively. The changes of comedonal lipids were associated with a significant elevation of the free sterols/cholesterol sulfate ratio of 86% from pretreatment levels (P〈0.05). The isotretinoin-induced changes of the comedonal lipid composition in direction to a pattern of epidermal lipids of normal desquamating stratum corneum are discussed as a possible comedolytic mechanism of oral isotretinoin treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417712
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  • 8
    Electronic Resource
    Electronic Resource
    Erysipelas carcinomatosum bei tubulärem Adenokarzinom des Magens (2000)
    Springer
    Der Hautarzt 51 (2000), S. 950-952 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Erysipelas carcinomatosum ; Erysipel ; Lymphogene Metastase ; Carcinoma erysipeloides ; Adenokarzinom ; Lymphangiosis carcinomatosa ; Keywords Erysipelas carcinomatosum ; Erysipelas ; Lymphogenic metastasis ; Carcinoma erysipeloides ; Adenocarcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Erysipelas carcinomatosum is an inflammatory infiltration of dermal lymphatic vessels by tumor cells of a metastatic adenocarcinoma mimicking common erysipelas. It is most often due to adenocarcinomas, especially breast cancer. A 51 year-old male patient developed erysipelas carcinomatosum on his right chest wall due to a tubular adenocarcinoma of the stomach.
    Notes: Zusammenfassung Erysipelas carcinomatosum ist eine inflammatorische, einem Erysipel ähnlich sehende Hautveränderung, die bei einem lymphogen metastasierenden Karzinom auftritt. Es handelt sich meist um Adenokarzinome, insbesondere Mammakarzinome. Wir weisen darauf hin, dass in der Literatur in der jüngsten Zeit anstelle des Begriffs Erysipelas carcinomatosum des Öfteren der Terminus Lymphangiosis carcinomatosa verwendet wird. Wir berichten über einen 51-jährigen männlichen Patienten, der ein Erysipelas carcinomatosum auf der rechten Thoraxhälfte bei einem tubulären Adenokarzinom des Magens entwickelte.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050051246
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