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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 279 (1987), S. S108 
    ISSN: 1432-069X
    Keywords: Pao ferro ; R-3,4 dimethoxydalbergione ; Contact dermatitis ; Allergy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pao ferro (Machaerium scleroxylum), used as a rosewood substitute, is a strong sensitizer capable of causing acute outbreaks of allergic and irritant dermatitis in workers not previously exposed to it. This, however, has not prevented furniture factories from using the product. Apparently, most workers develop tolerance to the wood.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 6 (1980), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 6 (1980), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 35 (1996), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sensitization to rubber is must often due to sensitization to thiurams. Positive patch test reactions to carbamates are less frequent, and usually only diagnosed in patients with positive patch test reactions to thiurams as well. The aim of the present study was to describe the relative frequency of sensitization to thiuram mix (TH mix) and zinc diethyldithiocarbamate (ZDC) in a population where the exposure to these chemicals from rubber gloves was previously studied and considered to be of approximately the same order of magnitude. The thiuram derivatives seemed to be the most important sensitizers (frequency 2.8%) compared to ZDC (frequency 0.5%) which has been the most frequently reported sensitizer among the carbamates in rubber gloves. An interesting observation was that the probability that the patient was reacting to ZDC was strongly associated with the strength of the patch test reaction to TH mix. This observation may add a new aspect to the discussion about cross-reactivity versus concomitant sensitization of thiurams and carbamates.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This article describes the results of an EECDRG multicentre study on contact allergy to corticosteroids. A total of 7238 patients were investigated: 6238 in 13 centres in the course of 1993, and 1000 patients in 1 centre in 1993 and 1994. The 5 corticosteroids tested were budesonide 0.1% pet., betamethasone-17-valerate 1% pet., clobetasol-17-propionate 1% pet., hydrocortisone-17-butyrate 1% eth., and tixoeortol-21-pivalate 1%., pet.; 189 (2.6%) gave a positive patehtest reaction (+, ++, +++)to at least 1 of the corticosieroids. The data regarding the corticosteroid-sensitive patients, as well as the patchtest results, were recorded on a standardized form.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 34 (1996), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An estimate of amounts of thiurams that may be released from rubber gloves into synthetic sweat, has previously been generated. These amounts should be compared to elicitation thresholds Of patch tests performed with serial dilutions of thiuram mix using synthetic sweat as vehicle. Because of solubility properties of thiurams in aqueous media, such dilutions cannot directly be prepared. In this study, a stem solution was prepared in ethanol. This solution was then further diluted with synthetic sweat. Thiuram mix 0.5 w/v% was the most concentrated solution in ethanol achievable. The parch test reactions were compared to reactions to serial dilutions using petrolatum as vehicle. The experiment revealed that endpoint dilution with synthetic sweat was not achieved in this study. The threshold for elicitation of positive patch test reactions seemed to be lower for ethanol/sweat a, vehicle compared to petrolatum: 32% reacted to ethanol/synthetic sweat 0.001 mg/cm2 compared to 14% reading to thiuram in pet. 0.0Q2 mg/cm2. Based on these results, synthetic sweat may be considered a more relevant medium for threshold finding studies than petrolatum. Because of expected instability of the aqueous solutions, petrolatum is probably a more suitable vehicle for routine testing. The study does not permit final conclusions concerning acceptable thresholds for reachable thiurams in rubber gloves, but it is likely that an acceptable threshold would be substantially less than 0001 mg/cm2.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 34 (1996), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of the present study was to assess exposure to constituents of the fragrance mix from cosmetic products used by fragrance-mix-positive eczema patients. 23 products, which had either given a positive patch and/or use test in a total of 11 fragrance-mix-positive patients, were analyzed. In all cases, the use of these cosmetics completely or partly explained present or past episodes of eczema. Between 1 to 6 constituents of the fragrance mix were found in 22 out of 21 products. The cosmetics of all the patients sensitive to hydroxycitronellal, eugenol, cinnamic alcohol and α- amylcinnamic aldehyde were found to contain the respective substances. Exposure concentrations were seen in cover a large range. The content of hydroxycitronellal was, on average, 5×higher in cosmetics from hydroxycitronellal-sensitive patients, compared to cosmetics from hydroxycitronellal-negative patients. It is concluded that exposure to constituents of the fragrance mix is common in fragrance-allergic patients with cosmetic eczema, and that the fragrance mix is a good relied inn of actual exposure.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 3 (1977), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Two patients with contact allergy to Ultralan® preparations are reported. Each Ultralan preparation contains two of three related fluocortolone derivatives. The first patient reacted to all three derivatives. The second patient reacted to fluocortolone and when retested 4 months later also to fluocortolone pivalate but not to fluocortolone caproate. The negative reaction to fluocortolone pivalate at the first examination was probably false negative due to a too low test concentration. In order to avoid false negative patch test reactions the fluorinated steroids should possibly be applied in concentrations higher than 1%. No cross sensitivity to the other steroids for topical use was found.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 9 (1983), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The Danish Twin Register represents a population-based twin sample where the twins enter the Register independently of disease.All female twins born between 1906–30 and available in the Register in January 1978 were sent a questionnaire concerning possible nickel sensitivity. Among 74ft pairs living in the eastern part of Denmark, 129 twins from 115 pairs had a possible nickel allergy. Through a subsequent personal visit and, in most eases, patch testing, 34 monozygotic probands from 30 pairs and 45 dizygotic probands from 41 pairs were considered to have a verified nickel sensitivity and fulfilled the restriction criteria for the present study.The prevalence of present or previous hand eczema in both the monozygotic and the dizygotic probands was 41% (95% confidence limits: 30–52%). In 15 of the 32 with hand eczema, this was in the form of a relapsing pompholyx.Analysis of the monozygotic pairs showed that the risk of developing hand eczema in the co-twins seemed independent of whether the proband had nickel allergy and hand eczema or nickel allergy alone. Furthermore, it was found that the number of affected co-twins was comparable with the background population. Thus the association between nickel allergy and hand eczema is probably not due to a common genetic predisposition. Environmental factors seem decisive.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 9 (1983), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A double Wind, placebo-controlled treatment with Antabuse® was carried out in 24 patients with hand eczema and nickel allergy. The amount of Antabuse® given was gradually increased from 50 to 200 mg daily. The maximum dose was given for ft weeks. During the treatment period, the dermatitis of 5 out of 11 patients in the group treated with Antabuse® healed, compared with 2 out of 13 in the group receiving the placebo. A statistical analysis was made of changes observed during the study, through the parameters: staling, frequency of flares, erythema, area involved and number of vesicles. Differences in results obtained with Antabuse® and the placebo were statistically significant only for the parameters scaling and frequency of flares (p 〈 0.05). The difference between the sums of parameters following the 2 forms of treatment was not statistically significant (p= 0.11). 2 patients treated with Antabuse® showed signs of hepatic toxicity; 1 of them had toxic hepatitis. No other significant side effects were seen.
    Type of Medium: Electronic Resource
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