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  • 1
    Electronic Resource
    Electronic Resource
    High eradication rates of Helicobacter pylori with a new sequential treatment (2003)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 17 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Eradication rates of Helicobacter pylori with standard triple therapy are disappointing, and studies from several countries confirm this poor performance.Aim : To assess the eradication rate of a new sequential treatment regimen compared with conventional triple therapy for the eradication of H. pylori infection.Methods : One thousand and forty-nine dyspeptic patients were studied prospectively. H. pylori-infected patients were randomized to receive 10-day sequential therapy [rabeprazole (40 mg daily) plus amoxicillin (1 g twice daily) for the first 5 days, followed by rabeprazole (20 mg), clarithromycin (500 mg) and tinidazole (500 mg) twice daily for the remaining 5 days] or standard 7-day treatment [rabeprazole (20 mg), clarithromycin (500 mg) and amoxicillin (1 g) twice daily]. H. pylori status was assessed by histology, rapid urease test and 13C-urea breath test at baseline and 6 weeks or more after completion of treatment.Results : Higher eradication rates were found with the sequential regimen compared to the standard regimen (intention-to-treat: 92% vs. 74%, P 〈 0.0001; per protocol: 95% vs. 77%, P 〈 0.0001). Higher eradication rates were also seen in patients with peptic ulcer disease and non-ulcer dyspepsia. In both treatments, compliance was similar (〉 90%), as was the rate of side-effects, which were mild.Conclusions : This 10-day sequential treatment regimen achieves high eradication rates in peptic ulcer disease and non-ulcer dyspepsia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2003.01461.x
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  • 2
    Electronic Resource
    Electronic Resource
    Randomized study of different ‘second-line’ therapies for Helicobacter pylori infection after failure of the standard ‘Maastricht triple therapy’ (2003)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 18 (2003), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Triple therapy with proton pump inhibitor, clarithromycin and amoxicillin and, in the event of eradication failure, quadruple therapy with proton pump inhibitor, bismuth, tetracycline and metronidazole have been proposed in Maastricht as the optimal sequential treatment of Helicobacter pylori infection.Aim : To compare two second-line regimens with quadruple therapy.Methods : One hundred and eighty patients with a previous failed course of standard therapy were randomly given one of the following 7-day treatments: ranitidine bismuth citrate 400 mg b.d. plus amoxicillin 1 g b.d. and tinidazole 500 mg b.d. (RBCAT), pantoprazole 40 mg b.d. plus amoxicillin 1 g b.d. and levofloxacin 500 mg/day (PAL) and pantoprazole 40 mg b.d., bismuth citrate 240 mg b.d., tetracycline 500 mg q.d.s. and metronidazole 500 mg b.d. (PBTM). The eradication rate was assessed by 13C-urea breath test. Side-effects and compliance were evaluated by a standardized questionnaire and by counting returned medication.Results : The RBCAT, PAL and PBTM groups achieved mean intention-to-treat eradication rates of 85%, 63% and 83%, respectively (P 〈 0.05 for PAL vs. either RBCAT or PBTM). Compliance was optimal in all patients, although side-effects were more commonly observed in the PBTM group than in the other two patient groups (P 〈 0.0001).Conclusions : Both RBCAT and PBTM can be used as second-line therapies. Conversely, PAL did not achieve satisfactory eradication rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2003.01755.x
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  • 3
    Electronic Resource
    Electronic Resource
    Appropriateness of urea breath test: a prospective observational study based on Maastricht 2000 guidelines (2002)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : The urea breath test is routinely used for diagnosing or confirming the eradication of Helicobacter pylori.Aim : To evaluate the appropriateness of urea breath test referrals.Methods : The age, sex, symptoms, endoscopic findings, use of non-steroidal anti-inflammatory drugs, family history of gastric cancer or H. pylori infection and concomitant diseases of patients referred for urea breath testing in a 1-year period were recorded. The appropriateness of urea breath test referrals was judged according to Maastricht guidelines.Results : One thousand, three hundred and twenty subjects (47 ± 16 years) were referred in 2001: 578 (43.8%) for the diagnosis and 742 (56.2%) for confirmation of the eradication of H. pylori. The urea breath test was considered to be appropriate in 836 (63.3%) patients, inappropriate in 192 (14.5%) and appropriate but avoidable in 292 (22.1%). The appropriateness ratios of urea breath test referrals were 4.6 and 9.0 (P 〈 0.0001) for general practitioners and gastroenterologists, respectively. Of the patients (n=230) with uninvestigated dyspepsia, who underwent urea breath testing according to a ‘test and treat’ strategy, 98 (42.6%) presented at least one risk factor for organic disease.Conclusions : In Italy, nearly 36% of urea breath test referrals are inappropriate or could be avoided if all dyspeptic patients with risk factors were referred for endoscopy or all dyspeptic patients undergoing endoscopy were tested for H. pylori infection with biopsy methods. Both general practitioners and, to a lesser extent, gastroenterologists require educational programmes to deal effectively with H. pylori.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2002.01315.x
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  • 4
    Electronic Resource
    Electronic Resource
    Heterometallische Clusterkomplexe der Typen Re2(μ-PR2)(CO)8(HgY) und ReMo(μ-PR2)(η5-C5H5)(CO)6(HgY) (R = Ph, Cy; Y = Cl, W(η5-C5H5)(CO)3)Professor Friedo Huber zum 65. Geburtstage gewidmet (1994)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 620 (1994), S. 999-1005 
    Details
    ISSN: 0044-2313
    Keywords: Heteronuclear dirhenium-mercury and rhenium-molybdenum-mercury cluster complexes ; preparation ; crystal structures ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Heterometallic Cluster Complexes of the Types Re2(μ-PR2)(CO)8(HgY) and ReMo(μ-PR2)(η5-C5H5)(CO)6(HgY) (R = Ph, Cy; Y = Cl, W(η5-C5H5)(CO)3)Dinuclear complexes Re2(μ-H)(μ-PR2)(CO)8 and ReMo(μ-H)(μ-PR2)(η5-C5H5)(CO)6 (R = phenyl, cyclohexyl) were deprotonated and reacted as anions with HgCl2 to compounds of the both types Re2(μ-PR2)(CO)8HgCl) and ReMo(μ-PR2)(η5-C5H5)(CO)6(HgCl). The heterometallic three-membered cluster complexes correspond to an isolobal exchange of a proton against a cationic HgCl+ group. For one of the products ReMo(μ-PCy2)(η5-C5H5)(CO)6(HgCl) has been shown its conversion with NaW(η5-C5H5)(CO)3 to ReMo(μ-PCy2)(η5-C5H5)(HgW(η5-C5H5)(CO)3) under substitution of the chloro ligand, par example. The newly prepared compounds were characterized by means of IR, UV/VIS and 31P NMR data. A complete determination of the molecular structure by single crystal analyses was done in the case of Re2(μ-PCy2)(CO)8(HgCl) and of ReMo(μ-PCy2)(η5-C5H5)(CO)6(HgCl) which both are dimer because of the presence of an asymmetric dichloro bridge, and of ReMo(μ-PCy2)(η5-C5H5)(CO)6(HgW(η5-C5H5)(CO)3). The structural study illustrates through comparison the influence of various metal types on an interaction between centric and edge-bridged frontier orbitals in three-membered metal rings.
    Notes: Zweikernkomplexe Re2(μ-H)(μ-PR2)(CO)8 und ReMo(μ-H)(μ-PR2)(η5-C5H5)(CO)6 (R = Phenyl, Cyclohexyl) wurden deprotoniert und als Anionen mit HgCl2 zu farbigen Verbindungen der beiden Typen Re2(μ-PR2)(CO)8-(HgCl) und ReMo(μ-PR2)(η5-C5H5)(CO)6(HgCl) umgesetzt. Die neuen heterometallischen Dreiringcluster entsprechen einem isolobalen Ersatz eines Protons gegen eine kationische HgCl+-Gruppe. Für eines der Produkte ReMo(μ-PCy2)(η5-C5H5(CO)6-(HgCl) wurde beispielhaft gezeigt, daß die Substitution des Chloroliganden mittels NaW(η5-C5H5)(CO)3 zu ReMo(μ-PCy2)-(η5-C5H5)(CO)6HgW(η5-C5H5)(CO)3) führt. Die erhaltenen Verbindungen wurden durch IR, UV/VIS und 31P-NMR Daten charakterisiert. Eine vollständige Molekülstrukturaufklärung wurde für Re2(μ-PCy2)(CO)8(HgCl) und ReMo(μ-PCy2)(η5-C5H5)(CO)6(HgCl), deren Moleküle im Festkörper über eine zweifache asymmetrische Chlorobrücke dimer vorliegen, und ReMo(μ-PCy2)(η5-C5H5)(CO)6(HgW(η5-C5H5(CO)3) durchgeführt. Die strukturelle Studie kennzeichnet durch Vergleich den Einfluß verschiedener Metalltypen für das kräftemäßige Zusammenspiel zentrierter und kantenverbrückender Grenzorbitale in Metalldreiringclustern.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19946200608
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